FR2189035A1 - Substd benzoylethylene diamine derivs - with antiemetic and choleretic activity - Google Patents

Substd benzoylethylene diamine derivs - with antiemetic and choleretic activity

Info

Publication number
FR2189035A1
FR2189035A1 FR7321850A FR7321850A FR2189035A1 FR 2189035 A1 FR2189035 A1 FR 2189035A1 FR 7321850 A FR7321850 A FR 7321850A FR 7321850 A FR7321850 A FR 7321850A FR 2189035 A1 FR2189035 A1 FR 2189035A1
Authority
FR
France
Prior art keywords
coch3
derivs
treatment
benzoylethylene
substd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7321850A
Other languages
French (fr)
Other versions
FR2189035B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Miquel SA Lab
Original Assignee
Miquel SA Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miquel SA Lab filed Critical Miquel SA Lab
Publication of FR2189035A1 publication Critical patent/FR2189035A1/en
Application granted granted Critical
Publication of FR2189035B1 publication Critical patent/FR2189035B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Otolaryngology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Derivs. of formula (I) (where X is H or COOCH3, R is O ,ICH3 or IC2H5, and n is 0 or 1) are specific agents for relaxing the sphincter of Oddi, as well as regulators of digestive function and agents for the symptomatic treatment of vomitting. (I); X = COCH3, n = 0) is prepd. by reacting 4-chloro-3-aminoanisole with acetyl chloride in the presence of a base to give 4-chloro-3-acetamidoanisole, acylating this, oxidising the acylation prodts. and reacting the oxidn. prodt. with diethylaminoethyl isocyanate. Treatment of (I; X = COCH3, n = 0) with an oxidising agent gives (I; X = COCH3, n = 1, R = 0), while treatment with CH3I or C2H5I gives (I; X = COCH3, n = 1, R = ICH3 or IC2H5). Treatment of (I; X = COCH3) with an acidic agent gives (I; X = H).
FR7321850A 1972-06-20 1973-06-15 Substd benzoylethylene diamine derivs - with antiemetic and choleretic activity Granted FR2189035A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES404497A ES404497A1 (en) 1972-06-20 1972-06-20 Procedure for the obtaining of derivatives of substitute benzoiletilendiaminas. (Machine-translation by Google Translate, not legally binding)

Publications (2)

Publication Number Publication Date
FR2189035A1 true FR2189035A1 (en) 1974-01-25
FR2189035B1 FR2189035B1 (en) 1976-12-31

Family

ID=8461615

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7321850A Granted FR2189035A1 (en) 1972-06-20 1973-06-15 Substd benzoylethylene diamine derivs - with antiemetic and choleretic activity

Country Status (5)

Country Link
JP (1) JPS5644065B2 (en)
AR (1) AR201912A1 (en)
DE (1) DE2330425B2 (en)
ES (1) ES404497A1 (en)
FR (1) FR2189035A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0002531D0 (en) * 2000-07-05 2000-07-05 Active Biotech Ab Immune Enhancement

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HOUBEN WEYL METHODEN DER ORGANISCHEN CHEMIE,BAND III, PAGE 415) *

Also Published As

Publication number Publication date
AR201912A1 (en) 1975-04-30
ES404497A1 (en) 1975-06-01
JPS4961134A (en) 1974-06-13
FR2189035B1 (en) 1976-12-31
DE2330425A1 (en) 1974-01-17
JPS5644065B2 (en) 1981-10-16
DE2330425B2 (en) 1976-02-19

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Legal Events

Date Code Title Description
ST Notification of lapse