FR2180568A1 - Org acid deriv x-ray contrast agents - iodinated -4-oxo -dihydropyridinyl,-substd phenylphenoxy-or -phenyl thio-acetic acids - Google Patents

Org acid deriv x-ray contrast agents - iodinated -4-oxo -dihydropyridinyl,-substd phenylphenoxy-or -phenyl thio-acetic acids

Info

Publication number
FR2180568A1
FR2180568A1 FR7214148A FR7214148A FR2180568A1 FR 2180568 A1 FR2180568 A1 FR 2180568A1 FR 7214148 A FR7214148 A FR 7214148A FR 7214148 A FR7214148 A FR 7214148A FR 2180568 A1 FR2180568 A1 FR 2180568A1
Authority
FR
France
Prior art keywords
phenylphenoxy
dihydropyridinyl
substd
iodinated
org
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7214148A
Other languages
French (fr)
Other versions
FR2180568B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Priority to FR7214148A priority Critical patent/FR2180568A1/en
Publication of FR2180568A1 publication Critical patent/FR2180568A1/en
Application granted granted Critical
Publication of FR2180568B1 publication Critical patent/FR2180568B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Abstract

Cpds. (I) XYCHCOOR (I) (where R is an electrophilic gp. and (a) X is H and Y is (II) or (III) or (b) X is CH3(CH2)n; n is 0 or 1-6 and Y is (IV); Z is O or S or (CH2)m; m is 0 or 1-6 and when Z is CH2, (IV) may also contain a 3-NH2 grp.) are prepd. by esterification of XYCHCOOR with an alcohol or phenol.
FR7214148A 1972-04-21 1972-04-21 Org acid deriv x-ray contrast agents - iodinated -4-oxo -dihydropyridinyl,-substd phenylphenoxy-or -phenyl thio-acetic acids Granted FR2180568A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7214148A FR2180568A1 (en) 1972-04-21 1972-04-21 Org acid deriv x-ray contrast agents - iodinated -4-oxo -dihydropyridinyl,-substd phenylphenoxy-or -phenyl thio-acetic acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7214148A FR2180568A1 (en) 1972-04-21 1972-04-21 Org acid deriv x-ray contrast agents - iodinated -4-oxo -dihydropyridinyl,-substd phenylphenoxy-or -phenyl thio-acetic acids

Publications (2)

Publication Number Publication Date
FR2180568A1 true FR2180568A1 (en) 1973-11-30
FR2180568B1 FR2180568B1 (en) 1975-12-26

Family

ID=9097289

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7214148A Granted FR2180568A1 (en) 1972-04-21 1972-04-21 Org acid deriv x-ray contrast agents - iodinated -4-oxo -dihydropyridinyl,-substd phenylphenoxy-or -phenyl thio-acetic acids

Country Status (1)

Country Link
FR (1) FR2180568A1 (en)

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Also Published As

Publication number Publication date
FR2180568B1 (en) 1975-12-26

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Legal Events

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