FR2162489A1 - Isocyanato-benzoxazoles-benzothiazoles and benimidazoles - as anthelmintics and antimicrobials - Google Patents

Isocyanato-benzoxazoles-benzothiazoles and benimidazoles - as anthelmintics and antimicrobials

Info

Publication number
FR2162489A1
FR2162489A1 FR7243386A FR7243386A FR2162489A1 FR 2162489 A1 FR2162489 A1 FR 2162489A1 FR 7243386 A FR7243386 A FR 7243386A FR 7243386 A FR7243386 A FR 7243386A FR 2162489 A1 FR2162489 A1 FR 2162489A1
Authority
FR
France
Prior art keywords
alkyl
opt
contg
acyl
alkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7243386A
Other languages
French (fr)
Other versions
FR2162489B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Priority claimed from CH1787572A external-priority patent/CH565536A5/xx
Publication of FR2162489A1 publication Critical patent/FR2162489A1/en
Application granted granted Critical
Publication of FR2162489B1 publication Critical patent/FR2162489B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms
    • C07D277/72—2-Mercaptobenzothiazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms
    • C07D277/74—Sulfur atoms substituted by carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms
    • C07D277/76—Sulfur atoms attached to a second hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Cpds (I) (where SCN occupies positions 4,5,6 or 7, R1 is H, 1-17C alkyl or alkenyl opt. substd. by CN, halogen, OH, Oalkyl, acyl, Salkyl or dialkylamino contg. up to a total of 6C, a mono-, bi- or tricyclic cycloalkyl or cycloalkenyl contg. 3-10 intracyclic C atoms and opt. substd. by alkyl gps. the cyclic radical opt. being linked to Y or to the heterocyclic residue by CH2-, R2 is H, halogen or 1-4C-alkyl, -Oalkyl or -acyl, X is O, S or NR3, R3 is H, 1-5C-alkyl or -alkenyl, Ph, PhCH2, dimethyl- or diethyl-amino-(2-5C-alkyl), 2-5C-alkoxycarbonyl or acyl or polyhydroxy alkyl (ose or oside), Y is O, S, SO SO2 or N-R4, n is 0 or 1, R4 is H, 1-5C-alkyl or -alkenyl, or together with the N-atom and R1 is a 4-, 5- or 6-membered heterocyclic ring opt. contg. a further O, S or NR5 residue and R5 is H, Me or Et) are prepd. by various methods from the corresponding amino cpd. or by cyclising an isothiocyanato-2-acylamino phenol, which cpd. also forms part of the invention.
FR7243386A 1972-12-08 1972-12-06 Isocyanato-benzoxazoles-benzothiazoles and benimidazoles - as anthelmintics and antimicrobials Granted FR2162489A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1787572A CH565536A5 (en) 1971-12-17 1972-12-08

Publications (2)

Publication Number Publication Date
FR2162489A1 true FR2162489A1 (en) 1973-07-20
FR2162489B1 FR2162489B1 (en) 1975-10-17

Family

ID=4428744

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7243386A Granted FR2162489A1 (en) 1972-12-08 1972-12-06 Isocyanato-benzoxazoles-benzothiazoles and benimidazoles - as anthelmintics and antimicrobials

Country Status (1)

Country Link
FR (1) FR2162489A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0356385A2 (en) * 1988-08-17 1990-02-28 Ciba-Geigy Ag New benzazole derivatives, processes for their preparation and pharmaceutical preparations containing such compounds and the use thereof
WO2003045930A1 (en) * 2001-11-28 2003-06-05 Astrazeneca Ab Therapeutic compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1587072A (en) * 1967-07-26 1970-03-13

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1587072A (en) * 1967-07-26 1970-03-13

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0356385A2 (en) * 1988-08-17 1990-02-28 Ciba-Geigy Ag New benzazole derivatives, processes for their preparation and pharmaceutical preparations containing such compounds and the use thereof
EP0356385A3 (en) * 1988-08-17 1990-08-01 Ciba-Geigy Ag New benzazole derivatives, processes for their preparation and pharmaceutical preparations containing such compounds and the use thereof
WO2003045930A1 (en) * 2001-11-28 2003-06-05 Astrazeneca Ab Therapeutic compounds

Also Published As

Publication number Publication date
FR2162489B1 (en) 1975-10-17

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