FR2149302A1 - 21-methyl pregnadienes prepn - used as progestomimetics - Google Patents

21-methyl pregnadienes prepn - used as progestomimetics

Info

Publication number
FR2149302A1
FR2149302A1 FR7130254A FR7130254A FR2149302A1 FR 2149302 A1 FR2149302 A1 FR 2149302A1 FR 7130254 A FR7130254 A FR 7130254A FR 7130254 A FR7130254 A FR 7130254A FR 2149302 A1 FR2149302 A1 FR 2149302A1
Authority
FR
France
Prior art keywords
progestomimetics
pregnadienes
prepn
methyl
ethylenedioxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7130254A
Other languages
French (fr)
Other versions
FR2149302B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7130254A priority Critical patent/FR2149302A1/en
Priority to DK401272AA priority patent/DK130992B/en
Priority to CA149,835A priority patent/CA975756A/en
Priority to JP8219772A priority patent/JPS5616800B2/ja
Publication of FR2149302A1 publication Critical patent/FR2149302A1/en
Application granted granted Critical
Publication of FR2149302B1 publication Critical patent/FR2149302B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Cpds. of formula (I): where Z = H or CH3, R = H, CH3, OR'1, R1 = H or carboxylic acyl, A' = alkyl (1-3C) are prepd. by methylating (CH3I) a 3,3-ethylenedioxy 20-oxo-19 norpregna-5,9-diene, followed by acid hydrolysis of the ethylenedioxy gp. and opt. acylation. Methylation gives a mixt. of mono- and dimethylated material, separable before or after hydrolysis.
FR7130254A 1971-08-19 1971-08-19 21-methyl pregnadienes prepn - used as progestomimetics Granted FR2149302A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FR7130254A FR2149302A1 (en) 1971-08-19 1971-08-19 21-methyl pregnadienes prepn - used as progestomimetics
DK401272AA DK130992B (en) 1971-08-19 1972-08-15 Process for the preparation of 21-methylpregna-4,9-diene derivatives.
CA149,835A CA975756A (en) 1971-08-19 1972-08-17 Procede de preparation des derives 21-methyles du pregnane
JP8219772A JPS5616800B2 (en) 1971-08-19 1972-08-18

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7130254A FR2149302A1 (en) 1971-08-19 1971-08-19 21-methyl pregnadienes prepn - used as progestomimetics

Publications (2)

Publication Number Publication Date
FR2149302A1 true FR2149302A1 (en) 1973-03-30
FR2149302B1 FR2149302B1 (en) 1974-09-06

Family

ID=9082025

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7130254A Granted FR2149302A1 (en) 1971-08-19 1971-08-19 21-methyl pregnadienes prepn - used as progestomimetics

Country Status (4)

Country Link
JP (1) JPS5616800B2 (en)
CA (1) CA975756A (en)
DK (1) DK130992B (en)
FR (1) FR2149302A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2755818A1 (en) * 1976-12-14 1978-06-15 Roussel Uclaf NEW STEROIDS, METHODS FOR THEIR PRODUCTION AND THEIR USE IN THE SYNTHESIS OF TRITIUM-LABELED STEROIDS
DE2814048A1 (en) * 1977-04-01 1978-10-12 Roussel Uclaf NEW STEROIDS, METHODS FOR THEIR PRODUCTION AND THEIR USE IN THE SYNTHESIS OF TRITIUM-LABELED STEROIDS
EP0007823A2 (en) * 1978-07-13 1980-02-06 Roussel-Uclaf 3,20-Dioxo-4,9-diene-21-hydroxy-steroid compounds, process for their preparation, their use in medicines and pharmaceutical compositions containing them
EP0574317A1 (en) * 1992-06-11 1993-12-15 Roussel Uclaf A new process for the preparation of 20-keto, 21-alpha-hydroxy steroids and intermediates therefor
US7868194B2 (en) 2004-10-21 2011-01-11 Industriale Chimica S.R.L. Process for the preparation of 21-hydroxy steroids with control of the epimeric distribution at the C-21 position

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2755818A1 (en) * 1976-12-14 1978-06-15 Roussel Uclaf NEW STEROIDS, METHODS FOR THEIR PRODUCTION AND THEIR USE IN THE SYNTHESIS OF TRITIUM-LABELED STEROIDS
DE2814048A1 (en) * 1977-04-01 1978-10-12 Roussel Uclaf NEW STEROIDS, METHODS FOR THEIR PRODUCTION AND THEIR USE IN THE SYNTHESIS OF TRITIUM-LABELED STEROIDS
EP0007823A2 (en) * 1978-07-13 1980-02-06 Roussel-Uclaf 3,20-Dioxo-4,9-diene-21-hydroxy-steroid compounds, process for their preparation, their use in medicines and pharmaceutical compositions containing them
FR2430953A1 (en) * 1978-07-13 1980-02-08 Roussel Uclaf NOVEL 3,20-DIOXO 4,9-DIENE 21-HYDROXYL DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
EP0007823A3 (en) * 1978-07-13 1980-05-14 Roussel-Uclaf 3,20-dioxo-4,9-diene-21-hydroxy-steroid compounds, process for their preparation, their use in medicines and pharmaceutical compositions containing them
EP0046001A1 (en) * 1978-07-13 1982-02-17 Roussel-Uclaf 3-Oxo or 3-ketal, 20-oxo-diene steroid compounds, process for their preparation and their utilization in the preparation of medicines
EP0574317A1 (en) * 1992-06-11 1993-12-15 Roussel Uclaf A new process for the preparation of 20-keto, 21-alpha-hydroxy steroids and intermediates therefor
FR2692267A1 (en) * 1992-06-11 1993-12-17 Roussel Uclaf Novel process for preparing 20-keto 21alpha-hydroxy steroid compounds and intermediates
US7868194B2 (en) 2004-10-21 2011-01-11 Industriale Chimica S.R.L. Process for the preparation of 21-hydroxy steroids with control of the epimeric distribution at the C-21 position

Also Published As

Publication number Publication date
FR2149302B1 (en) 1974-09-06
DK130992B (en) 1975-05-12
DK130992C (en) 1975-10-13
JPS5616800B2 (en) 1981-04-18
CA975756A (en) 1975-10-07
JPS4829756A (en) 1973-04-19

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Legal Events

Date Code Title Description
ST Notification of lapse