FR2135297A1 - Anti-inflammatory agents - contg s-triazolo 3,4-a)isoquinoline and derivs - Google Patents

Anti-inflammatory agents - contg s-triazolo 3,4-a)isoquinoline and derivs

Info

Publication number
FR2135297A1
FR2135297A1 FR7215936A FR7215936A FR2135297A1 FR 2135297 A1 FR2135297 A1 FR 2135297A1 FR 7215936 A FR7215936 A FR 7215936A FR 7215936 A FR7215936 A FR 7215936A FR 2135297 A1 FR2135297 A1 FR 2135297A1
Authority
FR
France
Prior art keywords
triazolo
isoquinoline
halo
methoxy
derivs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7215936A
Other languages
French (fr)
Other versions
FR2135297B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Chemical Works
Original Assignee
Mallinckrodt Chemical Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Chemical Works filed Critical Mallinckrodt Chemical Works
Publication of FR2135297A1 publication Critical patent/FR2135297A1/en
Application granted granted Critical
Publication of FR2135297B1 publication Critical patent/FR2135297B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines

Abstract

Anti-inflammatory pharmaceuticals are obtained by putting s-triazolo 3,4-a isoquinoline or 3-trifluoromethyl, 3-(N-morpholinylmethyl), 5-chloro, 7-nitro-, 6-methyl-, 6-cyano-, 5-methoxy-, 6-carbamido, 6-methoxy-, 7-nitro-3-trifluoromethyl-, 3,6-dichloro-3-styryl-3-methylthio, 3-ethylthio-, 8-methoxy-, 3-phenyl, 3-oxo, 3-thioxo, 3-(lower alkyl), 3-(lower alkyl)-6-halo-, 3-halo-, 6-halo- or 7-halo-s-triazolo 3,4-a isoquinoline, or their non-toxic acid addn. salts in a suitable form. The cpds. are pref. used in finely divided form with a particle size of 1-10 mu. They also have analgesic and antisecretory activity.
FR7215936A 1971-05-04 1972-05-04 Anti-inflammatory agents - contg s-triazolo 3,4-a)isoquinoline and derivs Granted FR2135297A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14019871A 1971-05-04 1971-05-04

Publications (2)

Publication Number Publication Date
FR2135297A1 true FR2135297A1 (en) 1972-12-15
FR2135297B1 FR2135297B1 (en) 1975-12-26

Family

ID=22490171

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7215936A Granted FR2135297A1 (en) 1971-05-04 1972-05-04 Anti-inflammatory agents - contg s-triazolo 3,4-a)isoquinoline and derivs

Country Status (2)

Country Link
FR (1) FR2135297A1 (en)
NL (1) NL7206042A (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3354164A (en) * 1965-10-23 1967-11-21 Geigy Chem Corp S-triazolo-[3, 4-a] isoquinolines and process
FR2003591A1 (en) * 1968-03-09 1969-11-07 Aspro Nicholas Ltd

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3354164A (en) * 1965-10-23 1967-11-21 Geigy Chem Corp S-triazolo-[3, 4-a] isoquinolines and process
FR2003591A1 (en) * 1968-03-09 1969-11-07 Aspro Nicholas Ltd

Also Published As

Publication number Publication date
FR2135297B1 (en) 1975-12-26
NL7206042A (en) 1972-11-07

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Legal Events

Date Code Title Description
ST Notification of lapse