FR2128621A1 - Injectable alpha-aescine solns - stabilised with alcohols - Google Patents

Injectable alpha-aescine solns - stabilised with alcohols

Info

Publication number
FR2128621A1
FR2128621A1 FR7207560A FR7207560A FR2128621A1 FR 2128621 A1 FR2128621 A1 FR 2128621A1 FR 7207560 A FR7207560 A FR 7207560A FR 7207560 A FR7207560 A FR 7207560A FR 2128621 A1 FR2128621 A1 FR 2128621A1
Authority
FR
France
Prior art keywords
aescine
solns
stabilised
alcohols
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7207560A
Other languages
French (fr)
Other versions
FR2128621B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Deutschland GmbH
Original Assignee
Klinge Pharma GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Klinge Pharma GmbH and Co filed Critical Klinge Pharma GmbH and Co
Publication of FR2128621A1 publication Critical patent/FR2128621A1/en
Application granted granted Critical
Publication of FR2128621B1 publication Critical patent/FR2128621B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Abstract

Stable solns. of alpha-aescine used as anticoagulants, showing pH 4.0-5.5 and suitable for injection are obtd. by the addn. of 5-15% EtOH and/or propyleneglycol.
FR7207560A 1971-03-11 1972-03-03 Injectable alpha-aescine solns - stabilised with alcohols Granted FR2128621A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19712111764 DE2111764A1 (en) 1971-03-11 1971-03-11 Stabilized aqueous alpha-escin solutions

Publications (2)

Publication Number Publication Date
FR2128621A1 true FR2128621A1 (en) 1972-10-20
FR2128621B1 FR2128621B1 (en) 1975-06-13

Family

ID=5801248

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7207560A Granted FR2128621A1 (en) 1971-03-11 1972-03-03 Injectable alpha-aescine solns - stabilised with alcohols

Country Status (6)

Country Link
AT (1) AT314737B (en)
BE (1) BE780411A (en)
DE (1) DE2111764A1 (en)
FR (1) FR2128621A1 (en)
LU (1) LU64937A1 (en)
NL (1) NL7202683A (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB754489A (en) * 1953-05-22 1956-08-08 Wellcome Found Injectable solutions of digoxin
FR1422009A (en) * 1961-02-23 1965-12-24 Chem Fab Tempelhof Process for the preparation of stable horse chestnut extracts containing saponin
BE667819A (en) * 1964-08-03 1966-02-03

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB754489A (en) * 1953-05-22 1956-08-08 Wellcome Found Injectable solutions of digoxin
FR1422009A (en) * 1961-02-23 1965-12-24 Chem Fab Tempelhof Process for the preparation of stable horse chestnut extracts containing saponin
BE667819A (en) * 1964-08-03 1966-02-03

Also Published As

Publication number Publication date
DE2111764A1 (en) 1972-09-21
AT314737B (en) 1974-04-25
BE780411A (en) 1972-09-11
FR2128621B1 (en) 1975-06-13
LU64937A1 (en) 1972-07-07
NL7202683A (en) 1972-09-13

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Legal Events

Date Code Title Description
ST Notification of lapse