FR2115089A1 - Medicaments contg trans carbocyclic or heterocyclic - nitro ethylene cpds - as antitumour and cytoxic agents - Google Patents

Medicaments contg trans carbocyclic or heterocyclic - nitro ethylene cpds - as antitumour and cytoxic agents

Info

Publication number
FR2115089A1
FR2115089A1 FR7042945A FR7042945A FR2115089A1 FR 2115089 A1 FR2115089 A1 FR 2115089A1 FR 7042945 A FR7042945 A FR 7042945A FR 7042945 A FR7042945 A FR 7042945A FR 2115089 A1 FR2115089 A1 FR 2115089A1
Authority
FR
France
Prior art keywords
trans
nitro
cpds
ethylene
antitumour
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7042945A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bpifrance Financement SA
Original Assignee
Agence National de Valorisation de la Recherche ANVAR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agence National de Valorisation de la Recherche ANVAR filed Critical Agence National de Valorisation de la Recherche ANVAR
Priority to FR7042945A priority Critical patent/FR2115089A1/en
Publication of FR2115089A1 publication Critical patent/FR2115089A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/54—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/01—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms
    • C07C205/03—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/01—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms
    • C07C205/03—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C205/04—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/06—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/08—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms
    • C07C205/09—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/14—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to acyclic carbon atoms
    • C07C205/16—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/19—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/28—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C205/31—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/32—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups bound to acyclic carbon atoms and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups

Abstract

The new compsns. contain trans nitro cpds. of formula (I): (where R is H or lower alkyl; R1 is 5- or 6-membered carbocycle or heterocycle linked through a C atom to the ethylene gp. and which may be substd. by one or more of amine, mono or di-alkylamine, nitro, halogen, alkyl, aralkyl, alkoxy, aralkoxy, hydroxy or methylenedioxy, or it may contain a carbon chain making with R1 an aromatic polycyclic system). Specific cpds. include trans beta-nitro 4-fluoro and 3,4,5-trimethoxy styrene, trans 2-nitro-1-(alpha-naphthyl)ethylene, trans 2-nitro-2-methyl-1-(beta-naphthyl)ethylene, trans beta-nitro 4-allyloxy 4-propoxy, 3-methyl-4-isopropyl and 2,6-dinitro-3-methyl-4-isopropyl styrenes.
FR7042945A 1970-11-30 1970-11-30 Medicaments contg trans carbocyclic or heterocyclic - nitro ethylene cpds - as antitumour and cytoxic agents Withdrawn FR2115089A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7042945A FR2115089A1 (en) 1970-11-30 1970-11-30 Medicaments contg trans carbocyclic or heterocyclic - nitro ethylene cpds - as antitumour and cytoxic agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7042945A FR2115089A1 (en) 1970-11-30 1970-11-30 Medicaments contg trans carbocyclic or heterocyclic - nitro ethylene cpds - as antitumour and cytoxic agents

Publications (1)

Publication Number Publication Date
FR2115089A1 true FR2115089A1 (en) 1972-07-07

Family

ID=9064921

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7042945A Withdrawn FR2115089A1 (en) 1970-11-30 1970-11-30 Medicaments contg trans carbocyclic or heterocyclic - nitro ethylene cpds - as antitumour and cytoxic agents

Country Status (1)

Country Link
FR (1) FR2115089A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002009684A2 (en) * 2000-07-28 2002-02-07 Georgetown University Erbb-2 selective small molecule kinase inhibitors
WO2004046081A1 (en) * 2002-11-15 2004-06-03 Dna Link, Inc. Beta-nitrostyrene compound and telomerase inhibitor having an anticancer activity
US7825145B2 (en) 2001-06-18 2010-11-02 Biodiem Ltd Antimicrobial and radioprotective compounds
CN104311426A (en) * 2014-10-27 2015-01-28 厦门大学 New application of aromatic nitroethylene compound
CN105265432A (en) * 2015-10-23 2016-01-27 上海应用技术学院 Application of (E)-1,2,3-trimethoxy-beta-nitrostyrolene

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002009684A2 (en) * 2000-07-28 2002-02-07 Georgetown University Erbb-2 selective small molecule kinase inhibitors
WO2002009684A3 (en) * 2000-07-28 2002-04-25 Univ Georgetown ERBB-2 selective small molecule kinase inhibitors
US7825145B2 (en) 2001-06-18 2010-11-02 Biodiem Ltd Antimicrobial and radioprotective compounds
US8158664B2 (en) 2001-06-18 2012-04-17 Biodiem Ltd. Antimicrobial and radioprotective compounds
US8569363B2 (en) 2001-06-18 2013-10-29 Biodiem Ltd. Antimicrobial and radioprotective compounds
US9045452B2 (en) 2001-06-18 2015-06-02 Biodiem Ltd. Antimicrobial and radioprotective compounds
WO2004046081A1 (en) * 2002-11-15 2004-06-03 Dna Link, Inc. Beta-nitrostyrene compound and telomerase inhibitor having an anticancer activity
CN104311426A (en) * 2014-10-27 2015-01-28 厦门大学 New application of aromatic nitroethylene compound
CN105265432A (en) * 2015-10-23 2016-01-27 上海应用技术学院 Application of (E)-1,2,3-trimethoxy-beta-nitrostyrolene
CN105265432B (en) * 2015-10-23 2018-02-02 上海应用技术学院 (E) purposes of 3,4,5 trimethoxy β nitrostyrolenes

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