FR20C1038I2 - BENZAMIDAZOLE DERIVATIVES - Google Patents

BENZAMIDAZOLE DERIVATIVES

Info

Publication number
FR20C1038I2
FR20C1038I2 FR20C1038C FR20C1038C FR20C1038I2 FR 20C1038 I2 FR20C1038 I2 FR 20C1038I2 FR 20C1038 C FR20C1038 C FR 20C1038C FR 20C1038 C FR20C1038 C FR 20C1038C FR 20C1038 I2 FR20C1038 I2 FR 20C1038I2
Authority
FR
France
Prior art keywords
benzamidazole
derivatives
benzamidazole derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR20C1038C
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of FR20C1038I1 publication Critical patent/FR20C1038I1/fr
Application granted granted Critical
Publication of FR20C1038I2 publication Critical patent/FR20C1038I2/en
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
FR20C1038C 2007-06-29 2020-08-20 BENZAMIDAZOLE DERIVATIVES Active FR20C1038I2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94728707P 2007-06-29 2007-06-29
US4164508P 2008-04-02 2008-04-02
PCT/IB2008/001575 WO2009004427A2 (en) 2007-06-29 2008-06-16 Benzimidazole derivatives

Publications (2)

Publication Number Publication Date
FR20C1038I1 FR20C1038I1 (en) 2020-10-02
FR20C1038I2 true FR20C1038I2 (en) 2021-08-13

Family

ID=40161351

Family Applications (1)

Application Number Title Priority Date Filing Date
FR20C1038C Active FR20C1038I2 (en) 2007-06-29 2020-08-20 BENZAMIDAZOLE DERIVATIVES

Country Status (46)

Country Link
US (2) US8148401B2 (en)
EP (1) EP2170860B9 (en)
JP (2) JP4567099B2 (en)
KR (1) KR101143246B1 (en)
CN (1) CN101687841B (en)
AP (1) AP2377A (en)
AR (1) AR067346A1 (en)
AU (1) AU2008272641B2 (en)
BR (1) BRPI0813412B8 (en)
CA (1) CA2690953C (en)
CL (1) CL2008001922A1 (en)
CO (1) CO6160232A2 (en)
CR (1) CR11150A (en)
CU (1) CU23847B1 (en)
CY (2) CY1118650T1 (en)
DK (1) DK2170860T5 (en)
DO (1) DOP2009000278A (en)
EA (1) EA016888B1 (en)
EC (1) ECSP099803A (en)
ES (1) ES2609258T3 (en)
FR (1) FR20C1038I2 (en)
GE (1) GEP20125702B (en)
GT (1) GT200900328A (en)
HK (1) HK1139658A1 (en)
HN (1) HN2008000974A (en)
HR (1) HRP20161562T2 (en)
HU (2) HUE030052T4 (en)
IL (1) IL202420A (en)
LT (2) LT2170860T (en)
MA (1) MA31466B1 (en)
ME (1) ME00962B (en)
MY (1) MY148636A (en)
NI (1) NI200900219A (en)
NL (1) NL301057I2 (en)
NO (1) NO2020027I1 (en)
NZ (1) NZ581889A (en)
PA (1) PA8785401A1 (en)
PE (2) PE20121010A1 (en)
PL (1) PL2170860T3 (en)
PT (1) PT2170860T (en)
RS (1) RS55395B9 (en)
SI (1) SI2170860T1 (en)
TN (1) TN2009000544A1 (en)
TW (1) TWI371451B (en)
UY (1) UY31164A1 (en)
WO (1) WO2009004427A2 (en)

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JP4567099B2 (en) 2007-06-29 2010-10-20 ファイザー・インク Benzimidazole derivatives
CA2735593C (en) 2008-09-03 2017-08-15 Repligen Corporation Compositions including 6-aminohexanoic acid derivatives as hdac inhibitors
JP2012529449A (en) * 2009-06-11 2012-11-22 シエナ ビオテク ソシエタ ペル アチオニ Hedgehog pathway antagonists and their therapeutic applications
EA201270311A1 (en) 2009-08-26 2012-09-28 Такеда Фармасьютикал Компани Лимитед CONDENSED HETEROCYCLIC DERIVATIVE AND ITS APPLICATION
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
US10010439B2 (en) 2010-06-13 2018-07-03 Synerz Medical, Inc. Intragastric device for treating obesity
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
US9056865B2 (en) 2010-10-20 2015-06-16 Pfizer Inc. Pyridine-2-derivatives as smoothened receptor modulators
JP5452459B2 (en) 2010-12-16 2014-03-26 株式会社Ｎｔｔドコモ Home base station and handover method
WO2012118782A1 (en) 2011-02-28 2012-09-07 Repligen Corporation Histone deacetylase inhibitors
US8957066B2 (en) 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US10059723B2 (en) 2011-02-28 2018-08-28 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US9051305B2 (en) 2011-03-08 2015-06-09 Eutropics Pharmaceuticals, Inc. Compositions and methods useful for treating diseases
FR2980477B1 (en) 2011-09-23 2013-10-18 Centre Nat Rech Scient NOVEL MODULATING COMPOUNDS OF THE HEDGEHOG PROTEIN SIGNALING PATH, THEIR MARKED FORMS, AND APPLICATIONS
WO2013045028A1 (en) * 2011-09-26 2013-04-04 Merck Patent Gmbh Benzyl piperidine compounds as lysophosphatidic acid (lpa) receptor antagonist
WO2013192423A2 (en) 2012-06-20 2013-12-27 Eutropics Pharmaceuticals, Inc. Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives
WO2014081953A1 (en) 2012-11-21 2014-05-30 Richard David J Methods and compositions useful for treating diseases involving bcl-2 family proteins with isoquinoline and quinoline derivatives
AU2014228344C1 (en) 2013-03-15 2019-02-07 Biomarin Pharmaceutical Inc. HDAC inhibitors
EP2996689A1 (en) 2013-04-17 2016-03-23 Albert-Ludwigs-Universität Freiburg Compounds for use as bromodomain inhibitors
US10732182B2 (en) 2013-08-01 2020-08-04 Eutropics Pharmaceuticals, Inc. Method for predicting cancer sensitivity
GB2519344A (en) * 2013-10-18 2015-04-22 Redx Pharma Ltd Compounds
AU2014342269B2 (en) 2013-10-30 2020-02-27 Eutropics Pharmaceuticals, Inc. Methods for determining chemosensitivity and chemotoxicity
PL3286176T3 (en) * 2015-04-24 2020-11-30 Pfizer Inc. Crystalline forms of 1-((2r,4r)-2-(1h-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea maleate
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
JP2020164722A (en) * 2019-03-29 2020-10-08 デクセリアルズ株式会社 Adhesive composition
US20230107634A1 (en) 2020-01-28 2023-04-06 Teva Pharmaceuticals International Gmbh Processes for the preparation of glasdegib and salt thereof and solid state forms of glasdegib maleate and process for preparation thereof
CN113248475B (en) * 2020-02-11 2023-03-17 中国科学院上海药物研究所 Heterocyclic substituted benzimidazole dimer or pharmaceutically acceptable salt, composition and application thereof
EP4126237B1 (en) 2020-03-26 2024-04-10 LEK Pharmaceuticals d.d. Dimaleate form of 1-((2r,4r)-2-(1h-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea
US20230301950A1 (en) 2020-06-26 2023-09-28 Raqualia Pharma Inc. Method for selecting cancer patients for whom combination therapy with retinoid and cancer therapeutic agent is effective, and combination medicament with retinoid and cancer therapeutic agent
WO2023002362A1 (en) 2021-07-22 2023-01-26 Pfizer Inc. Treatment of hematological malignancy

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040031782A (en) 2001-07-27 2004-04-13 쿠리스 인코퍼레이션 Mediators of Hedgehog Signaling Pathways, Compositions and Uses Related Thereto
AU2002358071B2 (en) * 2001-12-04 2008-06-12 Actelion Pharmaceuticals Ltd 4-(piperidyl- and pyrrolidyl-alkyl-ureido)-quinolines as urotensin II receptor antagonists
TW200304820A (en) 2002-03-25 2003-10-16 Avanir Pharmaceuticals Use of benzimidazole analogs in the treatment of cell proliferation
AU2003301436A1 (en) 2002-10-17 2004-05-04 Amgen Inc. Benzimidazole derivatives and their use as vanilloid receptor ligands
WO2005042495A1 (en) 2003-10-21 2005-05-12 Imclone Systems Incorporated (benzimidazol-2-yl)-phenyl-phenyl-urea compounds and methods for inhibiting heparanase activity
ZA200603864B (en) 2003-10-28 2007-09-26 Vertex Pharma Benzimidazoles useful as modulators of ion channels
US7816369B2 (en) * 2004-11-03 2010-10-19 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
DE102005012875B4 (en) 2005-03-19 2006-11-16 Sanofi-Aventis Deutschland Gmbh Use of amino-substituted 8-N-benzimidazoles
WO2006124780A2 (en) * 2005-05-12 2006-11-23 Kalypsys, Inc. Ih-benzo [d] imidazole compounds as inhibitors of b-raf kinase
WO2008064830A1 (en) 2006-11-27 2008-06-05 Ucb Pharma, S.A. Bicyclic and heterobicyclic derivatives, processes for preparing them and their pharmaceutical uses
JP2010513263A (en) 2006-12-15 2010-04-30 ファイザー・プロダクツ・インク Benzimidazole derivatives
JP4567099B2 (en) 2007-06-29 2010-10-20 ファイザー・インク Benzimidazole derivatives
US20120094974A1 (en) 2008-06-17 2012-04-19 Wei Chen Smoothened receptor modulators
EA018721B1 (en) 2008-08-25 2013-10-30 Айрм Ллк Hedgehog pathway modulators

Also Published As

Publication number Publication date
US20120157495A1 (en) 2012-06-21
WO2009004427A3 (en) 2009-06-04
MA31466B1 (en) 2010-06-01
JP2010280693A (en) 2010-12-16
LTC2170860I2 (en) 2022-03-10
HK1139658A1 (en) 2010-09-24
CY2020028I2 (en) 2020-11-25
EP2170860B9 (en) 2017-02-22
EP2170860A2 (en) 2010-04-07
JP4567099B2 (en) 2010-10-20
PT2170860T (en) 2017-01-04
CN101687841A (en) 2010-03-31
RS55395B9 (en) 2020-01-31
AU2008272641B2 (en) 2013-08-29
LTPA2020528I1 (en) 2020-09-25
CN101687841B (en) 2013-07-10
KR101143246B1 (en) 2012-05-18
HRP20161562T2 (en) 2017-04-21
FR20C1038I1 (en) 2020-10-02
HUE030052T2 (en) 2017-04-28
CY1118650T1 (en) 2017-07-12
CU20090225A7 (en) 2012-02-15
CR11150A (en) 2010-02-08
GEP20125702B (en) 2012-12-10
DK2170860T5 (en) 2017-03-20
US20090005416A1 (en) 2009-01-01
TWI371451B (en) 2012-09-01
AR067346A1 (en) 2009-10-07
EA200971104A1 (en) 2010-06-30
WO2009004427A2 (en) 2009-01-08
CU23847B1 (en) 2012-10-15
RS55395B1 (en) 2017-04-28
LT2170860T (en) 2017-01-10
MY148636A (en) 2013-05-15
EA016888B1 (en) 2012-08-30
HUS2000031I1 (en) 2020-09-28
NZ581889A (en) 2011-05-27
AP2377A (en) 2012-03-07
BRPI0813412A2 (en) 2014-12-30
US8148401B2 (en) 2012-04-03
SI2170860T1 (en) 2017-01-31
AP2009005089A0 (en) 2009-12-31
HRP20161562T1 (en) 2016-12-30
IL202420A (en) 2014-05-28
NL301057I2 (en) 2020-09-10
HN2008000974A (en) 2011-01-24
CA2690953A1 (en) 2009-01-08
CA2690953C (en) 2012-10-02
ECSP099803A (en) 2010-01-29
NL301057I1 (en) 2020-07-22
PL2170860T3 (en) 2017-05-31
KR20100028120A (en) 2010-03-11
CY2020028I1 (en) 2020-11-25
EP2170860B1 (en) 2016-11-02
PE20121010A1 (en) 2012-08-06
AU2008272641A1 (en) 2009-01-08
DK2170860T3 (en) 2017-01-09
HUE030052T4 (en) 2017-06-28
UY31164A1 (en) 2009-01-30
TN2009000544A1 (en) 2011-03-31
ES2609258T3 (en) 2017-04-19
BRPI0813412B8 (en) 2021-05-25
PA8785401A1 (en) 2009-01-23
GT200900328A (en) 2011-08-29
JP2010531869A (en) 2010-09-30
BRPI0813412B1 (en) 2020-01-21
IL202420A0 (en) 2010-06-30
NO2020027I1 (en) 2020-08-11
CL2008001922A1 (en) 2009-01-02
ME00962B (en) 2012-06-20
NI200900219A (en) 2010-03-11
PE20090772A1 (en) 2009-06-24
US8431597B2 (en) 2013-04-30
DOP2009000278A (en) 2009-12-31
TW200911792A (en) 2009-03-16
CO6160232A2 (en) 2010-05-20

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