FR2077887A1 - Sulphonamide pyrimidine derivs for lowering - Google Patents

Sulphonamide pyrimidine derivs for lowering

Info

Publication number
FR2077887A1
FR2077887A1 FR7006313A FR7006313A FR2077887A1 FR 2077887 A1 FR2077887 A1 FR 2077887A1 FR 7006313 A FR7006313 A FR 7006313A FR 7006313 A FR7006313 A FR 7006313A FR 2077887 A1 FR2077887 A1 FR 2077887A1
Authority
FR
France
Prior art keywords
sulphonamide
lowering
derivs
pyrimidine
iso
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7006313A
Other languages
French (fr)
Other versions
FR2077887B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Priority to FR7006313A priority Critical patent/FR2077887A1/en
Publication of FR2077887A1 publication Critical patent/FR2077887A1/en
Application granted granted Critical
Publication of FR2077887B1 publication Critical patent/FR2077887B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/69—Benzenesulfonamido-pyrimidines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Sulphonamidepyrimidine derivs. (I): (where R1, R3 and R4 are H, 1-5C, n- or iso-alkyl, or F, Cl, Br or I; R2 is H or 1-5 C n- or iso-alkyl and n is zero or 1) have higher blood-sugar lowering activity than "Tolbutamide" (RTM). (I) are prepd. by reacting a 2-amino-pyrimidine : with a benzenesulphonyl R4-C6H4-SO2X (II) (where x is Cl or Br or a reactive gp. capable of forming -SO2NH, such as a mixed acid anhydride, ester or cyanide gp.) in opt. presence of an inert solvent and in presence of an acylation catalyst. Prepn. of (III) is also claimed.
FR7006313A 1970-02-23 1970-02-23 Sulphonamide pyrimidine derivs for lowering Granted FR2077887A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7006313A FR2077887A1 (en) 1970-02-23 1970-02-23 Sulphonamide pyrimidine derivs for lowering

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7006313A FR2077887A1 (en) 1970-02-23 1970-02-23 Sulphonamide pyrimidine derivs for lowering

Publications (2)

Publication Number Publication Date
FR2077887A1 true FR2077887A1 (en) 1971-11-05
FR2077887B1 FR2077887B1 (en) 1973-03-16

Family

ID=9051069

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7006313A Granted FR2077887A1 (en) 1970-02-23 1970-02-23 Sulphonamide pyrimidine derivs for lowering

Country Status (1)

Country Link
FR (1) FR2077887A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2753E (en) * 1900-01-01

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2753E (en) * 1900-01-01

Also Published As

Publication number Publication date
FR2077887B1 (en) 1973-03-16

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Legal Events

Date Code Title Description
ST Notification of lapse