FR2070682A1 - Malaria therapy with quinoline derivs - Google Patents

Malaria therapy with quinoline derivs

Info

Publication number
FR2070682A1
FR2070682A1 FR7032902A FR7032902A FR2070682A1 FR 2070682 A1 FR2070682 A1 FR 2070682A1 FR 7032902 A FR7032902 A FR 7032902A FR 7032902 A FR7032902 A FR 7032902A FR 2070682 A1 FR2070682 A1 FR 2070682A1
Authority
FR
France
Prior art keywords
pref
quinoline
halogen
iii
inert solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7032902A
Other languages
French (fr)
Other versions
FR2070682B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DANN OTTO DT
Original Assignee
DANN OTTO DT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DANN OTTO DT filed Critical DANN OTTO DT
Publication of FR2070682A1 publication Critical patent/FR2070682A1/en
Application granted granted Critical
Publication of FR2070682B1 publication Critical patent/FR2070682B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Quinoline derivs (II) active against malaria and other blood parasites consist of (where R1 and R2 are halogen, OH, 1-4C alkoxy, 1-9C alkyl, phenethyl, styryl or benzyloxy and R1 can also be H), and their addition salts. They are prepared by (a) condensation of quinoline deriv. (III) with cpds. IV (H5C2)2N-(CH2)3-CY-CH3 (where Y is bifunctional groups such as -O- or geminal alkoxy groups) pref. in presence of acid catalysts, in melt or inert solvent, at 110-220 degrees C, followed by reduction of Schiff's base obtained, pref. with catalytically activated H2, at raised temp. and pressure, or with complex metal hydrides; or (b) by alkylating (III) with (H5C2)2N. (CH2)3. CHX. CH3 (where X is monofunctional group such as halogen or reactive ester group) pref. in inert solvent and presence of acid binders.
FR7032902A 1969-09-10 1970-09-10 Malaria therapy with quinoline derivs Granted FR2070682A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19691945660 DE1945660A1 (en) 1969-09-10 1969-09-10 New quinoline derivatives

Publications (2)

Publication Number Publication Date
FR2070682A1 true FR2070682A1 (en) 1971-09-17
FR2070682B1 FR2070682B1 (en) 1974-02-01

Family

ID=5745004

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7032902A Granted FR2070682A1 (en) 1969-09-10 1970-09-10 Malaria therapy with quinoline derivs

Country Status (6)

Country Link
BE (1) BE755975A (en)
DE (1) DE1945660A1 (en)
FR (1) FR2070682A1 (en)
IL (1) IL35154A0 (en)
NL (1) NL7013265A (en)
ZA (1) ZA705950B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2618674B1 (en) * 1987-07-30 1990-06-15 Ire Celltarg Sa MICROPARTICLES COMPRISING A BIODEGRADABLE POLYMER CONTROLLING THE RELEASE OF AN ANTIMALARIA ACTIVE INGREDIENT, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AND METHOD OF PREPARATION

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Also Published As

Publication number Publication date
DE1945660A1 (en) 1971-03-11
ZA705950B (en) 1971-04-28
NL7013265A (en) 1971-03-12
IL35154A0 (en) 1970-10-30
FR2070682B1 (en) 1974-02-01
BE755975A (en) 1971-03-10

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Legal Events

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