FR2034481A1 - (2,3-epoxypropyl)-phosphonic acid derivs with - antibacterial activity - Google Patents

(2,3-epoxypropyl)-phosphonic acid derivs with - antibacterial activity

Info

Publication number
FR2034481A1
FR2034481A1 FR7002085A FR7002085A FR2034481A1 FR 2034481 A1 FR2034481 A1 FR 2034481A1 FR 7002085 A FR7002085 A FR 7002085A FR 7002085 A FR7002085 A FR 7002085A FR 2034481 A1 FR2034481 A1 FR 2034481A1
Authority
FR
France
Prior art keywords
antibacterial activity
epoxypropyl
phosphonic acid
acid derivs
nr1r2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7002085A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck et Cie
Merck and Co Inc
Original Assignee
Merck et Cie
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck et Cie, Merck and Co Inc filed Critical Merck et Cie
Publication of FR2034481A1 publication Critical patent/FR2034481A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65502—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
    • C07F9/65505—Phosphonic acids containing oxirane groups; esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/44—Amides thereof
    • C07F9/4461—Amides thereof the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4465—Amides thereof the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Mixtures of the (+) - and (-)-isomers of cpds. of formula (I) (where R1 is H or lower alkyl, X is O or S, and Y and Z are -OR, -SR, -NR1 R2, -NR-CHR-COOH, -NR- OR, -NR-NR1R2, -NR-N=CR1R2, -NR-C(=NR)-NR1 R2, -NH-CX-XR, -NH-CX- NR1R2, -N=C=X, -O-COR, -N3 or halogen, Y and Z not simultaneously being alkoxy; R is H or hydrocarbyl, R1 and R2 are H, hydrocarbyl, alkoxy or acyl) and salts of those cpds. in which Y and/or Z is -OH or -SH and cyclic derivs. in which Y and Z are linked through the residue of a polyfunctional hydrocarbon cpd. are new and have antibacterial activity. Processes for their manufacture and intermediates in such processes are also claimed.
FR7002085A 1969-01-23 1970-01-21 (2,3-epoxypropyl)-phosphonic acid derivs with - antibacterial activity Withdrawn FR2034481A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79357069A 1969-01-23 1969-01-23

Publications (1)

Publication Number Publication Date
FR2034481A1 true FR2034481A1 (en) 1970-12-11

Family

ID=25160219

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7002085A Withdrawn FR2034481A1 (en) 1969-01-23 1970-01-21 (2,3-epoxypropyl)-phosphonic acid derivs with - antibacterial activity

Country Status (4)

Country Link
BR (1) BR6914868D0 (en)
DE (1) DE2002807A1 (en)
FR (1) FR2034481A1 (en)
NL (1) NL7000226A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2833266A1 (en) * 2001-12-11 2003-06-13 Mayoly Spindler Lab NOVEL PHOSPHONATE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MODULATORS OF TGAMMA9 DELTA2 LYMPHOCYTE ACTIVITY

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2270021A1 (en) 2009-06-18 2011-01-05 Centre National de la Recherche Scientifique Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2833266A1 (en) * 2001-12-11 2003-06-13 Mayoly Spindler Lab NOVEL PHOSPHONATE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MODULATORS OF TGAMMA9 DELTA2 LYMPHOCYTE ACTIVITY
WO2003050128A1 (en) * 2001-12-11 2003-06-19 Laboratoire Mayoly Spindler Phosphonates useful as modulators of t $g(g)9$g(d)2 lymphocyte activity
JP2005511748A (en) * 2001-12-11 2005-04-28 ラボラトワール マヨリー スピンドレ Phosphonates useful as modulators of T-gamma-9-delta-2 lymphocyte activity
US8017596B2 (en) 2001-12-11 2011-09-13 Innate Pharma, S.A. Phosphonates useful as modulators of T-γ-9-δ-2 activity

Also Published As

Publication number Publication date
NL7000226A (en) 1970-07-27
BR6914868D0 (en) 1973-03-20
DE2002807A1 (en) 1970-07-30

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Legal Events

Date Code Title Description
ST Notification of lapse