FR2029415A1 - 2-chloro-6alpha 9alpha-difluoro-16alpha-methylpregna-1 - Google Patents

2-chloro-6alpha 9alpha-difluoro-16alpha-methylpregna-1

Info

Publication number
FR2029415A1
FR2029415A1 FR6901893A FR6901893A FR2029415A1 FR 2029415 A1 FR2029415 A1 FR 2029415A1 FR 6901893 A FR6901893 A FR 6901893A FR 6901893 A FR6901893 A FR 6901893A FR 2029415 A1 FR2029415 A1 FR 2029415A1
Authority
FR
France
Prior art keywords
activity
thymolytic
9alpha
6alpha
16alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR6901893A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Priority to FR6901893A priority Critical patent/FR2029415A1/en
Publication of FR2029415A1 publication Critical patent/FR2029415A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Cpds. of formula (I) R' = OH opt. esterified or etherified Y = H, OH opt. esterified. Thymolytic, suprarenal inhibitory and anti-inflammatory activity. 0.3-3 mg/kg. orally or 1-10 mg/kg. s.c. in rats markedly inhibits foreign-body-induced granuloma. The thymolytic effect is 10 times greater than the anti-inflammatory effect when a 21-acetate is admin. orally. The 21-pivalate corresponding to the 21-acetate has a similar anti-inflammatory activity but the thymolytic activity is less than the anti-inflamm. activity. May be used in animal foods.
FR6901893A 1969-01-30 1969-01-30 2-chloro-6alpha 9alpha-difluoro-16alpha-methylpregna-1 Withdrawn FR2029415A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR6901893A FR2029415A1 (en) 1969-01-30 1969-01-30 2-chloro-6alpha 9alpha-difluoro-16alpha-methylpregna-1

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR6901893A FR2029415A1 (en) 1969-01-30 1969-01-30 2-chloro-6alpha 9alpha-difluoro-16alpha-methylpregna-1

Publications (1)

Publication Number Publication Date
FR2029415A1 true FR2029415A1 (en) 1970-10-23

Family

ID=9028374

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6901893A Withdrawn FR2029415A1 (en) 1969-01-30 1969-01-30 2-chloro-6alpha 9alpha-difluoro-16alpha-methylpregna-1

Country Status (1)

Country Link
FR (1) FR2029415A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3152154A (en) * 1961-06-24 1964-10-06 Vismara Francesco Spa 17-monoesters of 17alpha, 21-dihydroxy steroids and process for the preparation thereof
US3232835A (en) * 1957-12-04 1966-02-01 Pfizer & Co C 2-chloro prednisones and the 9alpha-fluoro derivatives thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3232835A (en) * 1957-12-04 1966-02-01 Pfizer & Co C 2-chloro prednisones and the 9alpha-fluoro derivatives thereof
US3152154A (en) * 1961-06-24 1964-10-06 Vismara Francesco Spa 17-monoesters of 17alpha, 21-dihydroxy steroids and process for the preparation thereof

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Legal Events

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ST Notification of lapse