FR2029415A1 - 2-chloro-6alpha 9alpha-difluoro-16alpha-methylpregna-1 - Google Patents
2-chloro-6alpha 9alpha-difluoro-16alpha-methylpregna-1Info
- Publication number
- FR2029415A1 FR2029415A1 FR6901893A FR6901893A FR2029415A1 FR 2029415 A1 FR2029415 A1 FR 2029415A1 FR 6901893 A FR6901893 A FR 6901893A FR 6901893 A FR6901893 A FR 6901893A FR 2029415 A1 FR2029415 A1 FR 2029415A1
- Authority
- FR
- France
- Prior art keywords
- activity
- thymolytic
- 9alpha
- 6alpha
- 16alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Cpds. of formula (I) R' = OH opt. esterified or etherified Y = H, OH opt. esterified. Thymolytic, suprarenal inhibitory and anti-inflammatory activity. 0.3-3 mg/kg. orally or 1-10 mg/kg. s.c. in rats markedly inhibits foreign-body-induced granuloma. The thymolytic effect is 10 times greater than the anti-inflammatory effect when a 21-acetate is admin. orally. The 21-pivalate corresponding to the 21-acetate has a similar anti-inflammatory activity but the thymolytic activity is less than the anti-inflamm. activity. May be used in animal foods.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR6901893A FR2029415A1 (en) | 1969-01-30 | 1969-01-30 | 2-chloro-6alpha 9alpha-difluoro-16alpha-methylpregna-1 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR6901893A FR2029415A1 (en) | 1969-01-30 | 1969-01-30 | 2-chloro-6alpha 9alpha-difluoro-16alpha-methylpregna-1 |
Publications (1)
Publication Number | Publication Date |
---|---|
FR2029415A1 true FR2029415A1 (en) | 1970-10-23 |
Family
ID=9028374
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR6901893A Withdrawn FR2029415A1 (en) | 1969-01-30 | 1969-01-30 | 2-chloro-6alpha 9alpha-difluoro-16alpha-methylpregna-1 |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2029415A1 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3152154A (en) * | 1961-06-24 | 1964-10-06 | Vismara Francesco Spa | 17-monoesters of 17alpha, 21-dihydroxy steroids and process for the preparation thereof |
US3232835A (en) * | 1957-12-04 | 1966-02-01 | Pfizer & Co C | 2-chloro prednisones and the 9alpha-fluoro derivatives thereof |
-
1969
- 1969-01-30 FR FR6901893A patent/FR2029415A1/en not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3232835A (en) * | 1957-12-04 | 1966-02-01 | Pfizer & Co C | 2-chloro prednisones and the 9alpha-fluoro derivatives thereof |
US3152154A (en) * | 1961-06-24 | 1964-10-06 | Vismara Francesco Spa | 17-monoesters of 17alpha, 21-dihydroxy steroids and process for the preparation thereof |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CD | Change of name or company name | ||
ST | Notification of lapse |