FR2005620A1 - Salts of cephalosporin derivs. with benzylamine or collidine - Google Patents

Salts of cephalosporin derivs. with benzylamine or collidine

Info

Publication number
FR2005620A1
FR2005620A1 FR6910216A FR6910216A FR2005620A1 FR 2005620 A1 FR2005620 A1 FR 2005620A1 FR 6910216 A FR6910216 A FR 6910216A FR 6910216 A FR6910216 A FR 6910216A FR 2005620 A1 FR2005620 A1 FR 2005620A1
Authority
FR
France
Prior art keywords
collidine
benzylamine
salts
substd
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR6910216A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Publication of FR2005620A1 publication Critical patent/FR2005620A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/12—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/32—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by an araliphatic carboxylic acid, which is substituted on the aliphatic radical by hetero atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

(A) Salts (I) of cephalosporin derivs. (II) with benzylamine or collidine (IV) Ar = an aromatic or heteroaromatic residue, opt. substd. e.g. by one or more hal, OH, lower alkyl, NO2, NH2 subst. NH2, lower alkanoyl, lower Oalkyl or lower Salkyl. R' = H, OAc, OH, or a substd. nucleophilic residue e.g. N3 or Oether. R2 = an N-protecting group R3 = H or an N-protecting grp. forming a ring together with R2 (B) Improved method for the purification of cephalosporins. 7beta-(D(-)-alpha-amino-alpha-phenyl-acetamido)-3-methylceph-3-em- -4-carboxylic acid (12.26 g.).
FR6910216A 1968-04-05 1969-04-03 Salts of cephalosporin derivs. with benzylamine or collidine Withdrawn FR2005620A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1659368 1968-04-05
GB1508169 1969-03-21

Publications (1)

Publication Number Publication Date
FR2005620A1 true FR2005620A1 (en) 1969-12-12

Family

ID=26251023

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6910216A Withdrawn FR2005620A1 (en) 1968-04-05 1969-04-03 Salts of cephalosporin derivs. with benzylamine or collidine

Country Status (7)

Country Link
BE (1) BE731184A (en)
CH (1) CH546793A (en)
DE (1) DE1917423A1 (en)
FR (1) FR2005620A1 (en)
IE (1) IE33045B1 (en)
NL (1) NL6905073A (en)
SE (1) SE372273B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50108286A (en) * 1974-02-07 1975-08-26

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT367060B (en) * 1979-01-25 1982-05-25 Biochemie Gmbh METHOD FOR PRODUCING NEW CEPHALOSPORINE DERIVATIVES
FR2686187B1 (en) * 1992-01-13 1994-03-18 Merlin Gerin CIRCUIT BREAKER AND NEUTRAL DISCONNECTOR WITH INSULATING HOOD.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50108286A (en) * 1974-02-07 1975-08-26
JPS5857438B2 (en) * 1974-02-07 1983-12-20 藤沢薬品工業株式会社 7- dithicanphenylglycinamide -luka methyl -3- cefem -4- carbonsanyudotai no seizouhou

Also Published As

Publication number Publication date
IE33045B1 (en) 1974-03-06
CH546793A (en) 1974-03-15
NL6905073A (en) 1969-10-07
IE33045L (en) 1969-10-05
BE731184A (en) 1969-10-08
DE1917423A1 (en) 1970-01-29
SE372273B (en) 1974-12-16

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Legal Events

Date Code Title Description
ST Notification of lapse