FR19C1042I2 - MORPHINANE DERIVATIVE SUBSTITUTED BY A CARBAMOYL IN POSITION 7 AND HAVING AN INSAURATION IN POSITION 6,7 - Google Patents

MORPHINANE DERIVATIVE SUBSTITUTED BY A CARBAMOYL IN POSITION 7 AND HAVING AN INSAURATION IN POSITION 6,7

Info

Publication number
FR19C1042I2
FR19C1042I2 FR19C1042C FR19C1042C FR19C1042I2 FR 19C1042 I2 FR19C1042 I2 FR 19C1042I2 FR 19C1042 C FR19C1042 C FR 19C1042C FR 19C1042 C FR19C1042 C FR 19C1042C FR 19C1042 I2 FR19C1042 I2 FR 19C1042I2
Authority
FR
France
Prior art keywords
insauration
carbamoyl
derivative substituted
morphinane derivative
morphinane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR19C1042C
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of FR19C1042I1 publication Critical patent/FR19C1042I1/fr
Application granted granted Critical
Publication of FR19C1042I2 publication Critical patent/FR19C1042I2/en
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
FR19C1042C 2005-05-25 2019-06-20 MORPHINANE DERIVATIVE SUBSTITUTED BY A CARBAMOYL IN POSITION 7 AND HAVING AN INSAURATION IN POSITION 6,7 Active FR19C1042I2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2005151864 2005-05-25
JP2006065762 2006-03-10
PCT/JP2006/310231 WO2006126529A1 (en) 2005-05-25 2006-05-23 6,7-unsaturated-7-carbamoyl substituted morphinan derivative
PCT/JP2006/310454 WO2006126637A1 (en) 2005-05-25 2006-05-25 6,7-unsaturated-7-carbamoyl substituted morphinan derivative

Publications (2)

Publication Number Publication Date
FR19C1042I1 FR19C1042I1 (en) 2019-08-09
FR19C1042I2 true FR19C1042I2 (en) 2020-06-19

Family

ID=37451954

Family Applications (1)

Application Number Title Priority Date Filing Date
FR19C1042C Active FR19C1042I2 (en) 2005-05-25 2019-06-20 MORPHINANE DERIVATIVE SUBSTITUTED BY A CARBAMOYL IN POSITION 7 AND HAVING AN INSAURATION IN POSITION 6,7

Country Status (19)

Country Link
US (4) USRE46365E1 (en)
EP (1) EP1889848B8 (en)
JP (1) JP4323547B2 (en)
KR (1) KR100912782B1 (en)
CN (1) CN101228172B (en)
AU (1) AU2006250390B2 (en)
BR (1) BRPI0610343B8 (en)
CA (1) CA2609733C (en)
DK (1) DK1889848T3 (en)
ES (1) ES2525215T3 (en)
FR (1) FR19C1042I2 (en)
HU (1) HUS1900034I1 (en)
MX (1) MX2007014588A (en)
NL (1) NL300996I2 (en)
PL (1) PL1889848T3 (en)
PT (1) PT1889848E (en)
RU (1) RU2403255C2 (en)
TW (1) TWI311056B (en)
WO (2) WO2006126529A1 (en)

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WO2006126529A1 (en) 2005-05-25 2006-11-30 Shionogi & Co., Ltd. 6,7-unsaturated-7-carbamoyl substituted morphinan derivative
US8173666B2 (en) 2007-03-12 2012-05-08 Nektar Therapeutics Oligomer-opioid agonist conjugates
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates
CA2905541C (en) * 2008-01-09 2020-02-11 Charleston Laboratories, Inc. Pharmaceutical compositions comprising an antiemetic and an opioid analgesic
JP5252391B2 (en) * 2008-02-21 2013-07-31 学校法人北里研究所 Morphinane derivative having oxabicyclo [2.2.2] octane and pharmaceutical use thereof
JP5827123B2 (en) * 2008-09-16 2015-12-02 ウェルズ ファーゴ バンク ナショナル アソシエイション PEGylated opioids with low potential for abuse
KR20120092592A (en) * 2009-09-18 2012-08-21 아돌로 코포레이션 Use of opioid receptor antagonist for gastrointestinal tract disorders
CN102906099A (en) * 2010-05-13 2013-01-30 株式会社绿十字 (+)-3-hydroxymorphinan-based polycycle derivatives as neuroprotectants
PT2639234T (en) * 2010-11-12 2019-09-27 Shionogi & Co Crystalline 6,7-unsaturated-7-carbamoyl morphinane derivative, and method for producing same
DK2851075T3 (en) * 2012-05-14 2022-01-31 Shionogi & Co PREPARATION CONTAINING 6,7-UNSaturated -7-CARBAMOYL MORPHININE DERIVATIVE
JP7076171B2 (en) 2016-12-26 2022-05-27 塩野義製薬株式会社 Method for manufacturing a pharmaceutical product with improved content uniformity
JP7365358B2 (en) 2018-04-12 2023-10-19 モーフィック セラピューティック，インコーポレイテッド Antagonist of human integrin α4β7
KR102201609B1 (en) * 2019-04-19 2021-01-12 연성정밀화학(주) Process for Preparing Naldemedine
TW202332675A (en) 2019-10-16 2023-08-16 美商莫菲克醫療股份有限公司 Inhibiting human integrin α4β7
EP4062973A4 (en) 2019-11-20 2023-11-29 Shionogi & Co., Ltd 6,7-unsaturated-7-carbamoyl morphinan derivative-containing solid formulation
CN111905111B (en) * 2020-09-16 2023-03-31 地奥集团成都药业股份有限公司 Method for evaluating curative effect of compound glutamine composition on diarrhea-predominant irritable bowel syndrome

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US4272541A (en) 1978-06-02 1981-06-09 Miles Laboratories, Inc. 7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them
US4275205A (en) * 1980-05-05 1981-06-23 Miles Laboratories, Inc. 7,7-Ditosyloxymethyl-4,5α-epoxy-morphinan-6-ols
US4347361A (en) * 1980-12-10 1982-08-31 Sisa, Incorporated 4,5α-Epoxy-3-hydroxy or methoxy-7-(1-hydroxy-alkyl or 1-oxoalkyl)morphinan-6-one compounds
US4370333A (en) 1981-06-29 1983-01-25 Sisa, Incorporated 17-Cyclopropylmethyl-3-hydroxy-14-methoxy 7α-methyl-morphinan-6-one and therapeutic method of treating pain with it
US4443605A (en) * 1982-07-30 1984-04-17 Miles Laboratories, Inc. 7β-Arylalkyl-6α, 7 α-oxymethylene-3-methoxy or 3-hydroxy-4, 5α-epoxy-17 methyl or 17-cycloalkyl-methyl morphinans
US4440932A (en) * 1982-09-09 1984-04-03 Miles Laboratories, Inc. 7β-Arylalkyl-7α-methyl-6-oxo or 6α-hydroxy-3-methoxy or 3-hydroxy-4,5α-epoxy-17-methyl or 17-cycloalkyl-methylmorphinans
ES2146654T3 (en) * 1993-07-23 2000-08-16 Toray Industries DERIVATIVE OF MORFINANO AND MEDICAL USE.
US5464841A (en) 1993-11-08 1995-11-07 Univ Minnesota Use of delta opioid receptor antagonists to treat immunoregulatory disorders
AU706370B2 (en) 1996-01-10 1999-06-17 Smithkline Beecham Spa Heterocycle-condensed morphinoid derivatives (II)
WO2001002375A1 (en) 1999-07-01 2001-01-11 Chemrx Advanced Technologies, Inc. Process for synthesizing oxadiazoles
EP1244447B1 (en) * 1999-11-29 2007-01-10 Adolor Corporation Novel methods and compositions involving opioids and antagonists thereof
JP2004501094A (en) * 2000-05-05 2004-01-15 ペイン・セラピューティクス・インコーポレイテッド Novel compositions and methods for enhancing the efficacy of opioid agonists or reducing the deleterious side effects of opioid agonists
US20040024004A1 (en) 2001-05-04 2004-02-05 Sherman Barry M. Novel compositions and methods for enhancing potency or reducing adverse side effects of opioid agonists
CA2408106A1 (en) 2000-05-05 2001-11-15 Pain Therapeutics, Inc. Opioid antagonist compositions and dosage forms
ES2239170T3 (en) * 2000-10-31 2005-09-16 Rensselaer Polytechnic Institute 2,6-METHANE-3-BENZAZOCINAS REPLACED IN POSITION 8 AND MORFINANS REPLACED IN POSITION 3 AS AGENTS BINDING TO OPIOID RECEPTORS.
WO2002042309A1 (en) * 2000-11-22 2002-05-30 Toray Industries, Inc. Indole derivatives and use thereof in medicines
DE10161963A1 (en) * 2001-12-17 2003-07-03 Johannes Schuetz 6-aminomorphine derivatives, production process therefor and their use
DE10229842A1 (en) * 2002-07-03 2004-02-05 Helmut Prof. Dr. Schmidhammer Morphinane derivatives and their quaternary ammonium salts substituted in position 14, production process and use
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JP2006502190A (en) 2002-09-18 2006-01-19 ザ キュレイターズ オブ ザ ユニバーシティー オブ ミズーリ Opiate analogs selective for delta-opioid receptors
US20040157784A1 (en) * 2003-02-10 2004-08-12 Jame Fine Chemicals, Inc. Opiod tannate compositions
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WO2006126529A1 (en) 2005-05-25 2006-11-30 Shionogi & Co., Ltd. 6,7-unsaturated-7-carbamoyl substituted morphinan derivative
PT2639234T (en) 2010-11-12 2019-09-27 Shionogi & Co Crystalline 6,7-unsaturated-7-carbamoyl morphinane derivative, and method for producing same

Also Published As

Publication number Publication date
WO2006126637A1 (en) 2006-11-30
CA2609733A1 (en) 2006-11-30
KR100912782B1 (en) 2009-08-18
BRPI0610343B8 (en) 2021-05-25
CN101228172A (en) 2008-07-23
EP1889848A4 (en) 2011-08-10
MX2007014588A (en) 2008-01-24
AU2006250390B2 (en) 2010-07-08
EP1889848B1 (en) 2014-10-15
RU2007148412A (en) 2009-06-27
US20120135978A1 (en) 2012-05-31
USRE46375E1 (en) 2017-04-25
CA2609733C (en) 2011-07-19
JP4323547B2 (en) 2009-09-02
WO2006126529A1 (en) 2006-11-30
RU2403255C2 (en) 2010-11-10
JPWO2006126637A1 (en) 2008-12-25
EP1889848A1 (en) 2008-02-20
AU2006250390A1 (en) 2006-11-30
US8536192B2 (en) 2013-09-17
EP1889848B8 (en) 2014-12-17
DK1889848T3 (en) 2014-12-01
US20090203723A1 (en) 2009-08-13
PL1889848T3 (en) 2015-04-30
PT1889848E (en) 2014-12-09
USRE46365E1 (en) 2017-04-11
NL300996I1 (en) 2019-07-03
BRPI0610343A2 (en) 2010-06-15
US8084460B2 (en) 2011-12-27
ES2525215T3 (en) 2014-12-19
TW200726470A (en) 2007-07-16
HUS1900034I1 (en) 2019-07-29
TWI311056B (en) 2009-06-21
BRPI0610343B1 (en) 2020-03-10
KR20080014791A (en) 2008-02-14
NL300996I2 (en) 2019-07-30
CN101228172B (en) 2013-04-03
FR19C1042I1 (en) 2019-08-09

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