FR1978M - Medicinal product based on benzodiazepine derivatives. - Google Patents

Medicinal product based on benzodiazepine derivatives.

Info

Publication number
FR1978M
FR1978M FR901235A FR901235A FR1978M FR 1978 M FR1978 M FR 1978M FR 901235 A FR901235 A FR 901235A FR 901235 A FR901235 A FR 901235A FR 1978 M FR1978 M FR 1978M
Authority
FR
France
Prior art keywords
product based
medicinal product
benzodiazepine derivatives
benzodiazepine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR901235A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of FR1978M publication Critical patent/FR1978M/en
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR901235A 1961-06-20 1962-06-19 Medicinal product based on benzodiazepine derivatives. Active FR1978M (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US118243A US3405122A (en) 1961-06-20 1961-06-20 Novel 3h-1, 4-benzodiazepin-2-(1h)-ones
US130757A US3100770A (en) 1961-06-20 1961-08-11 5-pyridyl-1,4-benzodiazepine compounds
US326340A US3398159A (en) 1961-06-20 1963-11-27 Aminophenyl heterocyclic ketones
US326341A US3407211A (en) 1961-06-20 1963-11-27 Acylaminophenyl heterocyclic ketones
US326338A US3400128A (en) 1961-06-20 1963-11-27 Heterocyclic intermediates

Publications (1)

Publication Number Publication Date
FR1978M true FR1978M (en) 1963-08-19

Family

ID=27537521

Family Applications (1)

Application Number Title Priority Date Filing Date
FR901235A Active FR1978M (en) 1961-06-20 1962-06-19 Medicinal product based on benzodiazepine derivatives.

Country Status (7)

Country Link
US (5) US3405122A (en)
CH (4) CH425808A (en)
DE (1) DE1445862A1 (en)
FR (1) FR1978M (en)
GB (1) GB948888A (en)
NL (4) NL6700180A (en)
SE (4) SE303752B (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3261828A (en) * 1962-10-04 1966-07-19 Hoffmann La Roche 3h-1,4-benzodiazepine-2,5(1h,4h)-dione compounds
US3184448A (en) * 1962-10-16 1965-05-18 American Home Prod Benzodiazepinium compounds
US3336296A (en) * 1962-10-26 1967-08-15 American Home Prod Preparation of 5-substituted-2h-1, 4-benzodiazepin-2-one-4-oxides
US3192199A (en) * 1963-03-01 1965-06-29 Freeman H Mcmillan Process for the production of 1-cycloalkyl derivatives of 1, 4-benzodiazepine
US3321467A (en) * 1963-11-27 1967-05-23 Hoffmann La Roche 3-halo-1, 4-benzodiazepin-2-ones
US3182067A (en) * 1964-04-09 1965-05-04 Hoffmann La Roche Benzodiazepine compounds
NL131731C (en) * 1965-12-09
US3678043A (en) * 1966-03-14 1972-07-18 American Home Prod 2,3-dihydro-2-oxo-1h-1,4-benzodiazepine-3-carboxylic acid esters and related compounds
US3429874A (en) * 1966-12-22 1969-02-25 Schering Corp 1-polyhalogenoalkyl-2-oxo-1,3-dihydro-2h-1,4-benzodiazepines
US3506404A (en) * 1967-12-19 1970-04-14 Hoffmann La Roche Colorimetric method for determining iron in blood
US3506403A (en) * 1967-12-19 1970-04-14 Hoffmann La Roche Colorimetric method for determining iron in fluids
US3551427A (en) * 1969-05-09 1970-12-29 Sandoz Ag 4-thienyl-2-(1h)-quinazolones
US3856802A (en) * 1971-05-10 1974-12-24 Upjohn Co 1,6-DISUBSTITUTED-4H-5-{8 4,3-a{9 BENZODIAZEPINES
US4089953A (en) * 1973-06-20 1978-05-16 Ddsa Pharmaceuticals 1,5-Benzodiazocines
DE3124013A1 (en) * 1981-06-19 1982-12-30 Kali-Chemie Pharma Gmbh, 3000 Hannover 2-ACYLAMINOMETHYL-1,4-BENZODIAZEPINE COMPOUNDS, METHODS AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US5041438A (en) * 1989-10-30 1991-08-20 Hoffmann-La Roche Inc. Method for treating retroviral infections with benzodiazepine compounds
US5164376A (en) * 1989-10-30 1992-11-17 Hoffmann-Laroche Inc. Method for treating retroviral infections with aryl-(2-pyrryl) keytone compound
US5036101A (en) * 1989-10-30 1991-07-30 Hoffmann-La Roche Inc. Method for treating retroviral infections with aryl-(2-pyrryl) ketone compound
IE903879A1 (en) * 1989-10-30 1991-05-08 Hoffmann La Roche Use of a benzodiazepine and a phenylpyrrylketone derivative
US5141735A (en) * 1990-06-18 1992-08-25 Hoffman-La Roche, Inc. Substituted amino-benzodiazepines having anitviral activity
EP0491218A1 (en) * 1990-12-17 1992-06-24 F. Hoffmann-La Roche Ag Benzodiazepinones
AU3497293A (en) * 1992-02-26 1993-09-13 F. Hoffmann-La Roche Ag Benzodiazepinones and medicines containing them
SI9300288A (en) 1992-06-16 1993-12-31 Hoffmann La Roche Benzodiazepine derivatives
US5641773A (en) * 1993-11-30 1997-06-24 Dana-Farber Cancer Institute Methods for treating viral infections
IL159105A0 (en) * 2001-06-07 2004-05-12 Neuro3D Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof
DE10161767A1 (en) * 2001-12-15 2003-06-26 Merck Patent Gmbh New 2-guanidino-4-heterocyclyl-quinazoline derivatives, useful as sodium-proton antiporter subtype III inhibitors for treating e.g. respiratory, renal, ischemic or lipid metabolism disorders
WO2012125787A1 (en) 2011-03-17 2012-09-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic METHODS FOR TREATING LEUKEMIA AND DISORDERS MEDIATED BY CBFβ AND RUNX1 PROTEINS
US11229662B2 (en) 2016-11-15 2022-01-25 The Schepens Eye Research Institute, Inc. Compositions and methods for the treatment of aberrant angiogenesis
US11583497B2 (en) 2017-11-14 2023-02-21 The Schepens Eye Research Institute, Inc. Nano-emulsion of CBFß-RUNX1 inhibitor for ocular drug delivery
US11739326B2 (en) 2017-11-14 2023-08-29 Massachusetts Eye And Ear Infirmary RUNX1 inhibition for treatment of proliferative vitreoretinopathy and conditions associated with epithelial to mesenchymal transition
CN107903244B (en) * 2017-11-29 2019-06-14 武汉珈创生物技术股份有限公司 2- amido with anti-tumor activity replaces Benzodiazepine compound and preparation method thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2998421A (en) * 1961-08-29 Guanroevo compounds and method of
US2928837A (en) * 1960-03-15 Chj-chj
US2997479A (en) * 1955-07-01 1961-08-22 Endo Lab 1, 1-diphenyl-1-hydroxy-4-(pyrrolidyl)-butanone-2
US2962503A (en) * 1956-11-21 1960-11-29 American Cyanamid Co Nitropyrroles
US2944056A (en) * 1957-05-22 1960-07-05 Sumitomo Chemical Co Method of producing quinazoline derivatives
CH370076A (en) * 1959-01-09 1963-06-30 Cilag Chemie Aktiengesellschaf Process for the production of new iodinated acid amides
US2993905A (en) * 1959-04-24 1961-07-25 Us Vitamin Pharm Corp Nu-dialkylaminoalkyl, nu-pyridylethyl anilines
US2999091A (en) * 1959-10-23 1961-09-05 Abbott Lab 3,9-diazabicyclo[4.2.1]nonane derivatives
US3336295A (en) * 1960-12-02 1967-08-15 Hoffmann La Roche Hydroxy or alkoxy substituted 5-phenyl-3h-1, 4-benzodiazepin-2(1h)-ones

Also Published As

Publication number Publication date
CH445501A (en) 1967-10-31
CH425808A (en) 1966-12-15
SE317682B (en) 1969-11-24
GB948888A (en) 1964-02-05
NL122319C (en)
US3398159A (en) 1968-08-20
NL279830A (en)
SE301811B (en) 1968-06-24
SE303752B (en) 1968-09-09
US3407211A (en) 1968-10-22
US3400128A (en) 1968-09-03
NL6700180A (en) 1967-03-28
CH445502A (en) 1967-10-31
US3100770A (en) 1963-08-13
DE1445862A1 (en) 1969-01-30
CH450438A (en) 1968-01-31
SE343060B (en) 1972-02-28
NL131733C (en)
US3405122A (en) 1968-10-08

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