FR16C0015I2 - CELLULAR PERPOSTING COUGH VACCINES AND CORRESPONDING PREPARATION PROCESSES - Google Patents
CELLULAR PERPOSTING COUGH VACCINES AND CORRESPONDING PREPARATION PROCESSESInfo
- Publication number
- FR16C0015I2 FR16C0015I2 FR16C0015C FR16C0015C FR16C0015I2 FR 16C0015 I2 FR16C0015 I2 FR 16C0015I2 FR 16C0015 C FR16C0015 C FR 16C0015C FR 16C0015 C FR16C0015 C FR 16C0015C FR 16C0015 I2 FR16C0015 I2 FR 16C0015I2
- Authority
- FR
- France
- Prior art keywords
- pref
- iii
- pertussis
- perposting
- cellular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 206010011224 Cough Diseases 0.000 title 1
- 230000001413 cellular effect Effects 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 201000005702 Pertussis Diseases 0.000 abstract 2
- 241000588807 Bordetella Species 0.000 abstract 1
- 241000588832 Bordetella pertussis Species 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 229940037003 alum Drugs 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 229960003983 diphtheria toxoid Drugs 0.000 abstract 1
- 238000010255 intramuscular injection Methods 0.000 abstract 1
- 239000007927 intramuscular injection Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 108010021711 pertactin Proteins 0.000 abstract 1
- 238000010254 subcutaneous injection Methods 0.000 abstract 1
- 239000007929 subcutaneous injection Substances 0.000 abstract 1
- 229960000814 tetanus toxoid Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/099—Bordetella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Vaccine for protecting humans against Bordetella pertussis infection comprises pertussis toxoid (I), filamentous haemagglutinin (II), pertactin (III) and agglutinogens (IV) of B. pertussis in relative amts. able to confer protection to >= 70% of an at-risk population. A single dose is 5-30 mu g (I) and (II), 3-15 mu g (III) and 1-10 mu g (IV), all expressed as nitrogen contents, esp. 10 mu g (I) and 5 mu g (II) or 20 mu g each of these, plus 5 mu g (III) and 3 mu g (IV). Vaccines are administered by subcutaneous or intramuscular injection. (IV) comprises fimbrial agglutinogens (Agg) 2 and 3 (pref. at ratio 1.5-2:1) but is free of Agg 1. These may also include diphtheria toxoid, pref. at 15 Lfs, and tetanus toxoid, pref. at 5 Lf, opt. also other non-Bordetella antigens. They can also include an adjuvant, specifically alum.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/433,646 US5877298A (en) | 1995-05-04 | 1995-05-04 | Acellular pertussis vaccines and methods of preparing thereof |
| US50174395A | 1995-07-12 | 1995-07-12 | |
| PCT/CA1996/000279 WO1996034883A1 (en) | 1995-05-04 | 1996-05-02 | Acellular pertussis vaccines and methods of preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR16C0015I1 FR16C0015I1 (en) | 2016-06-10 |
| FR16C0015I2 true FR16C0015I2 (en) | 2017-06-09 |
Family
ID=27029924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR16C0015C Active FR16C0015I2 (en) | 1995-05-04 | 2016-04-27 | CELLULAR PERPOSTING COUGH VACCINES AND CORRESPONDING PREPARATION PROCESSES |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6399076B2 (en) |
| EP (7) | EP1234579A1 (en) |
| CN (2) | CN1198099A (en) |
| AT (3) | ATE228851T1 (en) |
| AU (2) | AU710538B2 (en) |
| BR (2) | BR9608114A (en) |
| CA (3) | CA2433502A1 (en) |
| DE (3) | DE69625191T2 (en) |
| DK (3) | DK0826001T3 (en) |
| ES (2) | ES2180758T3 (en) |
| FR (1) | FR16C0015I2 (en) |
| HK (1) | HK1016191A1 (en) |
| LU (1) | LU93036I2 (en) |
| MX (1) | MX9708481A (en) |
| NL (1) | NL300804I2 (en) |
| NZ (2) | NZ306392A (en) |
| PT (3) | PT826001E (en) |
| WO (2) | WO1996034883A1 (en) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2646776B1 (en) * | 1989-05-12 | 1994-06-03 | Pasteur Institut | USE OF VACCINANT PREPARATIONS BASED ON ADENYL CYCLASE OR OF BACTERIA PRODUCING THEM AS PROTECTIVE ANTIGENS AGAINST THE EFFECTS OF BORDETELLA |
| CA2188424A1 (en) * | 1994-04-28 | 1995-11-09 | Akihiro Suehara | Method of separating protective components of bordetella pertussis |
| US6696065B1 (en) * | 1995-05-04 | 2004-02-24 | Aventis Pastuer Limited | Acellular pertussis vaccines and methods of preparation thereof |
| GB9611501D0 (en) * | 1996-06-03 | 1996-08-07 | Smithkline Beecham Biolog | Vaccine compositions |
| SK283565B6 (en) * | 1996-07-02 | 2003-09-11 | Connaught Laboratories Limited | Multivalent DTP-polio vaccines |
| JP4530317B2 (en) * | 1998-10-21 | 2010-08-25 | 学校法人北里研究所 | Vaccine formulation containing attenuated toxin |
| US8299210B2 (en) * | 2003-11-20 | 2012-10-30 | Sanofi Pasteur | Methods for purifying pertussis toxin and peptides useful therefor |
| BRPI0519923A8 (en) * | 2004-12-17 | 2018-01-23 | De Staat Der Nederlanden Vertegenwoordigd Door De Mini Van Vws | polypeptide, dna sequence, dna vector, antibody, bacterium, method for producing partially 3-0-deacylated lps, composition, uses of the bacterium, and isolated bordetella lps comprising at least partially 3-0-deacylated lps, vaccine, and, in vitro method for deacylating gram-negative lps or compositions comprising gram-negative lps, and for inducing an immune response against bordetella. |
| US8124397B2 (en) * | 2005-08-08 | 2012-02-28 | Oregon Health & Science University | Inactivating pathogens with oxidizing agents for vaccine production |
| EP1867638A1 (en) * | 2006-06-16 | 2007-12-19 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Procedure for the Conection of two Molecules via Diels-Alder Reactions with Inverse Electron Demand |
| PL2066344T3 (en) | 2006-09-07 | 2011-10-31 | Glaxosmithkline Biologicals Sa | Inactivated Poliovirus combination vaccine |
| CN100537767C (en) * | 2007-04-29 | 2009-09-09 | 中国药品生物制品检定所 | Recombinant expressed and the application of pertussis vaccine protective antigen |
| GB0822633D0 (en) * | 2008-12-11 | 2009-01-21 | Novartis Ag | Formulation |
| US20100330158A1 (en) * | 2009-03-31 | 2010-12-30 | Innopharma, Llc | Protein-assisted drug delivery system for the targeted administration of active agents |
| WO2010131111A1 (en) | 2009-05-11 | 2010-11-18 | Novartis Ag | Antigen purification process for pertactin antigen |
| EP2758429A4 (en) * | 2011-09-20 | 2015-09-02 | Bio Rad Laboratories | Removal of virucidal agents from biomolecule preparations |
| US20140234360A1 (en) | 2011-09-30 | 2014-08-21 | The United States of America, as represented by the Secretary, Dept.of Health and Human Services | Influenza vaccine |
| CN102584958A (en) * | 2012-02-08 | 2012-07-18 | 北京天坛生物制品股份有限公司 | Purification method for 69KD outer membrane protein of pertussis bacillus |
| CN102793915B (en) * | 2012-07-25 | 2013-10-23 | 天津康希诺生物技术有限公司 | Production method of acellular pertussis vaccine |
| SG11201506858SA (en) * | 2013-03-08 | 2015-09-29 | Crucell Holland Bv | Acellular pertussis vaccine |
| PL3302784T3 (en) | 2015-06-05 | 2022-01-17 | W.R. Grace & Co.-Conn. | Adsorbent bioprocessing clarification agents and methods of making and using the same |
| CN105106947A (en) * | 2015-07-21 | 2015-12-02 | 华兰生物工程股份有限公司 | Acellular pertussis vaccine detoxified with hydrogen peroxide and preparation method thereof |
| WO2018067582A2 (en) | 2016-10-03 | 2018-04-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hiv-1 env fusion peptide immunogens and their use |
| US11202824B2 (en) | 2016-10-31 | 2021-12-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Peptide fragments from filoviruses and their uses |
| WO2018176031A1 (en) | 2017-03-24 | 2018-09-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Glycan-masked engineered outer domains of hiv-1 gp120 and their use |
| KR102426041B1 (en) * | 2017-08-01 | 2022-07-29 | 주식회사 녹십자 | Method for obtaining bordetella pertussis related protein comprising processes of freezing and thawing |
| WO2019079337A1 (en) | 2017-10-16 | 2019-04-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Recombinant hiv-1 envelope proteins and their use |
| WO2020061564A1 (en) | 2018-09-23 | 2020-03-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hiv-1 env fusion peptide nanoparticle carrier conjugates and their use |
| EP3870703A1 (en) | 2018-10-22 | 2021-09-01 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Recombinant gp120 protein with v1-loop deletion |
| CN110358802B (en) * | 2019-08-16 | 2021-06-18 | 长春百克生物科技股份公司 | Method for removing pertussis component fimbrin 2/3 endotoxin |
| CN112094354B (en) * | 2020-11-05 | 2021-02-02 | 苏州世诺生物技术有限公司 | Acinetobacter paragallinarum genetic engineering subunit vaccine, preparation method and application thereof |
| US20240277829A1 (en) | 2021-08-03 | 2024-08-22 | The U.S.A., As Represented By The Secretary, Department Of Health And Human Services | Hiv-1 vaccination and samt-247 microbicide to prevent hiv-1 infection |
| WO2023192835A1 (en) | 2022-03-27 | 2023-10-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Base-covered hiv-1 envelope ectodomains and their use |
| CN117417419B (en) * | 2023-01-10 | 2024-04-19 | 康希诺生物股份公司 | Pertussis toxin detoxification method and cell-free pertussis combined vaccine |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4258029A (en) | 1979-04-23 | 1981-03-24 | Connaught Laboratories Limited | Synthetic adjuvants for stimulation of antigenic responses |
| DE3521994A1 (en) | 1985-06-20 | 1987-01-02 | Bayer Ag | N- (2-AMINOACYLAMIDO-2-DESOXY-HEXOSYL) -AMIDES, CARBAMATES AND UREAS, METHODS FOR THE PRODUCTION THEREOF AND THEIR USE IN MEDICINAL PRODUCTS |
| GB8601279D0 (en) * | 1986-01-20 | 1986-02-26 | Public Health Lab Service | Purification of pertussis antigens |
| US4705686A (en) | 1986-05-09 | 1987-11-10 | American Cyanamid | Process for the preparation of acellular Bordetalla pertussis vaccine |
| KR0168039B1 (en) * | 1987-09-04 | 1999-01-15 | 로버트 디. 웨스트 | Recombinant dna derived bordetella toxin subunit analogs |
| GB8727489D0 (en) | 1987-11-24 | 1987-12-23 | Connaught Lab | Detoxification of pertussis toxin |
| GB8807860D0 (en) | 1988-04-05 | 1988-05-05 | Connaught Lab | Pertussis vaccine |
| US4967176A (en) * | 1988-07-15 | 1990-10-30 | Raychem Corporation | Assemblies of PTC circuit protection devices |
| US5101014A (en) | 1989-02-10 | 1992-03-31 | United States Of America | Process for the purification of a 69,000 da outer membrane protein of Bordetella pertussis |
| WO1990012086A1 (en) * | 1989-03-31 | 1990-10-18 | Washington University | Bordetella vaccines |
| US5276142A (en) | 1989-12-11 | 1994-01-04 | American Cyanamid Company | Process for purification of a 69000 dalton antigenic protein from Bordetella pertussis |
| GB9007657D0 (en) * | 1990-04-04 | 1990-05-30 | Connaught Lab | Purification of a pertussis outer membrane protein(omp69) |
| EP0484621A3 (en) | 1990-07-11 | 1992-08-26 | American Cyanamid Company | Efficacious vaccines against bordetella pertussis comprising a combination of individually purified pertussis antigens |
| CA2188424A1 (en) * | 1994-04-28 | 1995-11-09 | Akihiro Suehara | Method of separating protective components of bordetella pertussis |
| FR2728170A1 (en) * | 1994-12-15 | 1996-06-21 | Pasteur Institut | ANTI-BORDETELLA CELL-LIKE VACCINE |
| US5877298A (en) * | 1995-05-04 | 1999-03-02 | Connaught Lab | Acellular pertussis vaccines and methods of preparing thereof |
-
1996
- 1996-05-02 NZ NZ306392A patent/NZ306392A/en not_active IP Right Cessation
- 1996-05-02 ES ES96911887T patent/ES2180758T3/en not_active Expired - Lifetime
- 1996-05-02 CN CN96195230A patent/CN1198099A/en active Pending
- 1996-05-02 BR BR9608114-7A patent/BR9608114A/en not_active Application Discontinuation
- 1996-05-02 CN CNB961952296A patent/CN100387618C/en not_active Expired - Lifetime
- 1996-05-02 AU AU54941/96A patent/AU710538B2/en not_active Expired
- 1996-05-02 DK DK96911887T patent/DK0826001T3/en active
- 1996-05-02 WO PCT/CA1996/000279 patent/WO1996034883A1/en active IP Right Grant
- 1996-05-02 DE DE69625191T patent/DE69625191T2/en not_active Expired - Lifetime
- 1996-05-02 CA CA002433502A patent/CA2433502A1/en not_active Abandoned
- 1996-05-02 DK DK96911886T patent/DK0824358T3/en active
- 1996-05-02 AT AT96911886T patent/ATE228851T1/en active
- 1996-05-02 AT AT96911887T patent/ATE221081T1/en active
- 1996-05-02 CA CA002220063A patent/CA2220063C/en not_active Expired - Lifetime
- 1996-05-02 PT PT96911887T patent/PT826001E/en unknown
- 1996-05-02 WO PCT/CA1996/000278 patent/WO1996034623A1/en active IP Right Grant
- 1996-05-02 NZ NZ306391A patent/NZ306391A/en not_active IP Right Cessation
- 1996-05-02 ES ES96911886T patent/ES2182971T3/en not_active Expired - Lifetime
- 1996-05-02 EP EP02012063A patent/EP1234579A1/en not_active Withdrawn
- 1996-05-02 DE DE69638326T patent/DE69638326D1/en not_active Expired - Lifetime
- 1996-05-02 EP EP02012064A patent/EP1234580A1/en not_active Withdrawn
- 1996-05-02 AU AU54940/96A patent/AU715417B2/en not_active Expired
- 1996-05-02 EP EP20030078354 patent/EP1405643A1/en not_active Withdrawn
- 1996-05-02 AT AT03078355T patent/ATE496634T1/en active
- 1996-05-02 PT PT03078355T patent/PT1393744E/en unknown
- 1996-05-02 EP EP02077074.9A patent/EP1233022B1/en not_active Expired - Lifetime
- 1996-05-02 EP EP96911886A patent/EP0824358B1/en not_active Expired - Lifetime
- 1996-05-02 BR BR9608115-5A patent/BR9608115A/en not_active Application Discontinuation
- 1996-05-02 MX MX9708481A patent/MX9708481A/en active IP Right Grant
- 1996-05-02 EP EP03078355A patent/EP1393744B1/en not_active Expired - Lifetime
- 1996-05-02 PT PT96911886T patent/PT824358E/en unknown
- 1996-05-02 EP EP96911887A patent/EP0826001B1/en not_active Expired - Lifetime
- 1996-05-02 DE DE69622555T patent/DE69622555T2/en not_active Expired - Lifetime
- 1996-05-02 CA CA002220048A patent/CA2220048C/en not_active Expired - Lifetime
- 1996-05-02 US US08/945,750 patent/US6399076B2/en not_active Expired - Lifetime
- 1996-05-02 DK DK03078355.9T patent/DK1393744T3/en active
-
1999
- 1999-03-15 HK HK99101064.1A patent/HK1016191A1/en not_active IP Right Cessation
-
2016
- 2016-04-21 LU LU93036C patent/LU93036I2/en unknown
- 2016-04-27 FR FR16C0015C patent/FR16C0015I2/en active Active
- 2016-04-28 NL NL300804C patent/NL300804I2/nl unknown
Also Published As
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