FR1604469A - Antirheumatic, diuretic, sedative n-substitu- - ted amides - Google Patents

Antirheumatic, diuretic, sedative n-substitu- - ted amides

Info

Publication number
FR1604469A
FR1604469A FR182827A FR182827A FR1604469A FR 1604469 A FR1604469 A FR 1604469A FR 182827 A FR182827 A FR 182827A FR 182827 A FR182827 A FR 182827A FR 1604469 A FR1604469 A FR 1604469A
Authority
FR
France
Prior art keywords
orally
antirheumatic
diuretic
sedative
substitu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR182827A
Other languages
French (fr)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to FR182827A priority Critical patent/FR1604469A/en
Priority to FR183302A priority patent/FR8287M/fr
Application granted granted Critical
Publication of FR1604469A publication Critical patent/FR1604469A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Pharmaceutical compositions containing as active ingredient a compound of formula Y.NH.CO.Ar where Y is benzhydryl, fluoren-9-yl-dibenzon 2,3;6,7 cycloheptadien-5-yl, xanthen-9-yl; Ar = aryl e.g. phenyl, naphthyl or heterocyclic e.g. pyridyl. The compounds are antirheumatic, antiinflammatory, analgesic, diuretic and sedative agents; 40-70% inhibition of mouse writhing at 50-200 mg/kg. orally, 40% reduction in the carrageenan-induced inflammation of the rat foot by 200 mg/kg. orally of N-(xanthen-9-yl) isonicotinamide; 10 mg/kg. orally of the same compound in the rat gives a 50% incease in urine output without significant loss of potassium. Very low toxicity; no deaths after 2000 mg/kg. orally in mice.
FR182827A 1968-12-31 1968-12-31 Antirheumatic, diuretic, sedative n-substitu- - ted amides Expired FR1604469A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR182827A FR1604469A (en) 1968-12-31 1968-12-31 Antirheumatic, diuretic, sedative n-substitu- - ted amides
FR183302A FR8287M (en) 1968-12-31 1969-03-28

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR182827A FR1604469A (en) 1968-12-31 1968-12-31 Antirheumatic, diuretic, sedative n-substitu- - ted amides

Publications (1)

Publication Number Publication Date
FR1604469A true FR1604469A (en) 1971-11-08

Family

ID=8659782

Family Applications (1)

Application Number Title Priority Date Filing Date
FR182827A Expired FR1604469A (en) 1968-12-31 1968-12-31 Antirheumatic, diuretic, sedative n-substitu- - ted amides

Country Status (1)

Country Link
FR (1) FR1604469A (en)

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Legal Events

Date Code Title Description
ST Notification of lapse