FR15C0010I2 - GLP-1 ANALOGUE HYBRID PROTEINS - Google Patents

GLP-1 ANALOGUE HYBRID PROTEINS

Info

Publication number
FR15C0010I2
FR15C0010I2 FR15C0010C FR15C0010C FR15C0010I2 FR 15C0010 I2 FR15C0010 I2 FR 15C0010I2 FR 15C0010 C FR15C0010 C FR 15C0010C FR 15C0010 C FR15C0010 C FR 15C0010C FR 15C0010 I2 FR15C0010 I2 FR 15C0010I2
Authority
FR
France
Prior art keywords
glp
hybrid proteins
analogue hybrid
analogue
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR15C0010C
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33551775&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR15C0010(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of FR15C0010I1 publication Critical patent/FR15C0010I1/fr
Application granted granted Critical
Publication of FR15C0010I2 publication Critical patent/FR15C0010I2/en
Active legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5063Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068Cell membranes or bacterial membranes enclosing drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/5176Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5184Virus capsids or envelopes enclosing drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/50Fibroblast growth factor [FGF]
    • C07K14/503Fibroblast growth factor [FGF] basic FGF [bFGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Botany (AREA)
  • Child & Adolescent Psychology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Emergency Medicine (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FR15C0010C 2003-06-12 2015-01-30 GLP-1 ANALOGUE HYBRID PROTEINS Active FR15C0010I2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47788003P 2003-06-12 2003-06-12
PCT/US2004/015595 WO2005000892A2 (en) 2003-06-12 2004-06-10 Glp-1 analog fusion plroteins

Publications (2)

Publication Number Publication Date
FR15C0010I1 FR15C0010I1 (en) 2015-03-13
FR15C0010I2 true FR15C0010I2 (en) 2015-07-24

Family

ID=33551775

Family Applications (1)

Application Number Title Priority Date Filing Date
FR15C0010C Active FR15C0010I2 (en) 2003-06-12 2015-01-30 GLP-1 ANALOGUE HYBRID PROTEINS

Country Status (28)

Country Link
US (2) US7452966B2 (en)
EP (2) EP2368909A1 (en)
JP (1) JP4629047B2 (en)
KR (1) KR100758755B1 (en)
CN (2) CN1802386B (en)
AR (1) AR044776A1 (en)
AT (1) ATE525395T1 (en)
AU (1) AU2004251145C1 (en)
BE (1) BE2015C007I2 (en)
BR (1) BRPI0411132B8 (en)
CA (1) CA2528591C (en)
CY (2) CY1111991T1 (en)
DK (1) DK1641823T3 (en)
EA (1) EA008831B1 (en)
ES (1) ES2371072T3 (en)
FR (1) FR15C0010I2 (en)
HR (1) HRP20110714T1 (en)
HU (1) HUS1500024I1 (en)
IL (1) IL171926A (en)
LT (1) LTC1641823I2 (en)
MX (1) MXPA05013565A (en)
NZ (1) NZ543292A (en)
PL (1) PL1641823T3 (en)
PT (1) PT1641823E (en)
SI (1) SI1641823T1 (en)
TW (1) TW200507870A (en)
UA (1) UA87458C2 (en)
WO (1) WO2005000892A2 (en)

Families Citing this family (186)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686899B1 (en) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa NOVEL BIOLOGICALLY ACTIVE POLYPEPTIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
US7183387B1 (en) 1999-01-15 2007-02-27 Genentech, Inc. Polypeptide variants with altered effector function
US7459540B1 (en) 1999-09-07 2008-12-02 Amgen Inc. Fibroblast growth factor-like polypeptides
JP2003530838A (en) 2000-04-12 2003-10-21 ヒューマン ゲノム サイエンシズ インコーポレイテッド Albumin fusion protein
US20030157108A1 (en) * 2001-10-25 2003-08-21 Genentech, Inc. Glycoprotein compositions
ES2425738T3 (en) 2001-12-21 2013-10-17 Human Genome Sciences, Inc. Albumin Fusion Proteins
AU2002364587A1 (en) 2001-12-21 2003-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
EP1594530A4 (en) 2003-01-22 2006-10-11 Human Genome Sciences Inc Albumin fusion proteins
US20070161087A1 (en) * 2003-05-29 2007-07-12 Wolfgang Glaesner Glp-1 fusion proteins
EA008831B1 (en) * 2003-06-12 2007-08-31 Эли Лилли Энд Компани SLIP PROTEINS OF GLP-1 ANALOGUES
EP1729795B1 (en) 2004-02-09 2016-02-03 Human Genome Sciences, Inc. Albumin fusion proteins
BRPI0519393A2 (en) * 2004-12-22 2009-01-20 Lilly Co Eli stable solution formulation
KR101011081B1 (en) * 2005-05-13 2011-01-25 일라이 릴리 앤드 캄파니 Pylated PL-1 Compound
WO2007012188A1 (en) * 2005-07-27 2007-02-01 Qinghua Wang GLP/1/EXENDM 4 IgG Fc FUSION CONSTRUCTS FOR TREATMENT OF DIABETES
US8278420B2 (en) 2005-08-06 2012-10-02 Qinghua Wang Composition and method for prevention and treatment of type I diabetes
PT1767545E (en) * 2005-09-22 2010-02-05 Biocompatibles Uk Ltd Glp-1 (glucagon-like peptide-1) fusion polypeptides with increased peptidase resistance
BRPI0617515A2 (en) * 2005-10-24 2011-07-26 Centocor Inc mimetibodies, polypeptides, compositions, methods and uses of glp-2
JP2009514900A (en) * 2005-11-04 2009-04-09 スミスクライン・ビーチャム・コーポレイション Administration method of hypoglycemic agent
US8338368B2 (en) * 2005-11-07 2012-12-25 Indiana University Research And Technology Corporation Glucagon analogs exhibiting physiological solubility and stability
US20130172274A1 (en) 2005-12-20 2013-07-04 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
US8841255B2 (en) 2005-12-20 2014-09-23 Duke University Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
EP1816201A1 (en) 2006-02-06 2007-08-08 CSL Behring GmbH Modified coagulation factor VIIa with extended half-life
MX2008013304A (en) 2006-04-20 2008-10-27 Amgen Inc Glp-1 compounds.
JP5290177B2 (en) * 2006-08-31 2013-09-18 セントカー・インコーポレーテツド GLP-2 mimetibodies, polypeptides, compositions, methods and uses
CN101578373A (en) * 2006-09-06 2009-11-11 费斯生物制药公司 Fusion peptide therapeutic compositions
US8338376B2 (en) * 2006-10-20 2012-12-25 Biogen Idec Ma Inc. Compositions comprising variant LT-B-R-IG fusion proteins
US8754194B2 (en) 2006-12-22 2014-06-17 Csl Behring Gmbh Modified coagulation factors with prolonged in vivo half-life
US20090098130A1 (en) * 2007-01-05 2009-04-16 Bradshaw Curt W Glucagon-like protein-1 receptor (glp-1r) agonist compounds
AU2011254001B2 (en) * 2007-01-05 2012-08-02 Covx Technologies Ireland Limited Glucagon-like protein-1 receptor (GLP-1R) agonist compounds
JP2008169195A (en) 2007-01-05 2008-07-24 Hanmi Pharmaceutical Co Ltd Insulin secretory peptide drug conjugates using carrier substances
WO2008086086A2 (en) * 2007-01-05 2008-07-17 Indiana University Research And Technology Corporation Glucagon analogs exhibiting enhanced solubility in physiological ph buffers
ES2753183T3 (en) 2007-02-12 2020-04-07 Csl Behring Gmbh Therapeutic application of Kazal-type serine protease inhibitors
JP6017754B2 (en) 2007-02-15 2016-11-02 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation Glucagon / GLP-1 receptor co-agonist
CN101951940A (en) * 2007-03-15 2011-01-19 比奥根艾迪克Ma公司 autoimmune disease treatment
TWI423821B (en) * 2007-06-19 2014-01-21 Glucose-containing glucagon-like peptide-1
US7960336B2 (en) * 2007-08-03 2011-06-14 Pharmain Corporation Composition for long-acting peptide analogs
JP2010535781A (en) * 2007-08-03 2010-11-25 イーライ リリー アンド カンパニー Treatment for obesity
US8563527B2 (en) * 2007-08-20 2013-10-22 Pharmain Corporation Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same
EP2031064A1 (en) * 2007-08-29 2009-03-04 Boehringer Ingelheim Pharma GmbH & Co. KG Method for increasing protein titres
CA2702289A1 (en) * 2007-10-30 2009-05-07 Indiana University Research And Technology Corporation Compounds exhibiting glucagon antagonist and glp-1 agonist activity
EP2217701B9 (en) 2007-10-30 2015-02-18 Indiana University Research and Technology Corporation Glucagon antagonists
US20100317057A1 (en) * 2007-12-28 2010-12-16 Novo Nordisk A/S Semi-recombinant preparation of glp-1 analogues
EP2249853A4 (en) * 2008-01-30 2012-12-26 Univ Indiana Res & Tech Corp PEPTIDE PRODRUGS BASED ON ESTERS
EA024751B8 (en) 2008-06-04 2020-01-31 Амген Инк. Fgf21 mutants and use thereof
JP5753779B2 (en) * 2008-06-17 2015-07-22 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation Glucagon analogs with improved solubility and stability in buffers at physiological pH
BRPI0915282A2 (en) * 2008-06-17 2017-02-07 Univ Indiana Res & Tech Corp gip-based mixed agonists for the treatment of metabolic disorders and obesity
AU2009260302B2 (en) 2008-06-17 2014-10-23 Indiana University Research And Technology Corporation Glucagon/GLP-1 receptor co-agonists
DK2865760T3 (en) 2008-06-24 2018-01-15 Csl Behring Gmbh Factor VIII, Von Willebrand Factor or complexes thereof with extended in vivo half-life
EP3412300A1 (en) 2008-06-27 2018-12-12 Duke University Therapeutic agents comprising elastin-like peptides
EP2358749B1 (en) 2008-10-10 2018-07-18 Amgen, Inc Fgf21 mutants and uses thereof
AU2009327418A1 (en) 2008-12-19 2010-06-24 Indiana University Research And Technology Corporation Amide based glucagon superfamily peptide prodrugs
WO2010096394A2 (en) 2009-02-17 2010-08-26 Redwood Biosciences, Inc. Aldehyde-tagged protein-based drug carriers and methods of use
US20120052069A1 (en) 2009-05-05 2012-03-01 Amgen Inc Fgf21 mutants and uses thereof
SMT202400036T1 (en) 2009-05-05 2024-03-13 Amgen Inc Fgf21 mutants and uses thereof
US9150632B2 (en) 2009-06-16 2015-10-06 Indiana University Research And Technology Corporation GIP receptor-active glucagon compounds
AU2010262927A1 (en) * 2009-06-17 2012-01-19 Amgen Inc. Chimeric FGF19 polypeptides and uses thereof
CN101993485B (en) 2009-08-20 2013-04-17 重庆富进生物医药有限公司 Peptide analog homologous dimer capable of accelerating insulin secretion and application thereof
WO2011043530A1 (en) * 2009-10-09 2011-04-14 (주)알테오젠 Glp-1 analog fusions, and composition for preventing or treating diabetes containing the fusions as an active ingredient
MX2012006397A (en) * 2009-12-02 2012-11-30 Amgen Inc Binding proteins that bind to human fgfr1c, human î²-klotho and both human fgfr1c and humanî²-klotho.
UA109888C2 (en) 2009-12-07 2015-10-26 ANTIBODY OR ANTIBODILITY ANTIBODY OR ITS BINDING TO THE β-CLOTE, FGF RECEPTORS AND THEIR COMPLEXES
WO2011075393A2 (en) 2009-12-18 2011-06-23 Indiana University Research And Technology Corporation Glucagon/glp-1 receptor co-agonists
RU2012136450A (en) 2010-01-27 2014-03-10 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн CONJUGATES GLUCAGON ANTAGONIST - GIP AGONIST AND COMPOSITIONS FOR TREATMENT OF METABOLIC DISORDERS AND OBESITY
EP2371857A1 (en) 2010-04-01 2011-10-05 CSL Behring GmbH Factor XII inhibitors for treating interstitial lung disease
US9517264B2 (en) 2010-04-15 2016-12-13 Amgen Inc. Human FGF receptor and β-Klotho binding proteins
JP5827218B2 (en) 2010-04-30 2015-12-02 株式会社三和化学研究所 Peptides for improving in vivo stability, such as physiologically active substances, and physiologically active substances with improved in vivo stability
EP2569000B1 (en) 2010-05-13 2017-09-27 Indiana University Research and Technology Corporation Glucagon superfamily peptides exhibiting nuclear hormone receptor activity
US9145451B2 (en) 2010-05-13 2015-09-29 Indiana University Research And Technology Corporation Glucagon superfamily peptides exhbiting G protein coupled receptor activity
CN101891823B (en) 2010-06-11 2012-10-03 北京东方百泰生物科技有限公司 Exendin-4 and analog fusion protein thereof
EP2588126A4 (en) 2010-06-24 2015-07-08 Univ Indiana Res & Tech Corp GLUCAGON SUPERFAMILY AMIDE PEPTIDE PRODRUGS
CN103415300B (en) * 2010-07-20 2018-02-23 诺沃—诺迪斯克有限公司 FGF21 compounds end modified N
CA2821766A1 (en) 2010-12-22 2012-06-28 Indiana University Research And Technology Corporation Glucagon analogs exhibiting gip receptor activity
US9540438B2 (en) 2011-01-14 2017-01-10 Redwood Bioscience, Inc. Aldehyde-tagged immunoglobulin polypeptides and methods of use thereof
EP2497489A1 (en) 2011-03-09 2012-09-12 CSL Behring GmbH Factor XII inhibitors for the treatment of silent brain ischemia and ischemia of other organs
ES2646191T3 (en) 2011-03-09 2017-12-12 Csl Behring Gmbh Factor XII inhibitors for administration with medical procedures comprising contact with artificial surfaces
BR112013024574B1 (en) 2011-03-29 2022-08-09 Roche Glycart Ag ANTIBODY AND ANTIBODY USE
BR112013032717A2 (en) 2011-06-22 2017-01-24 Univ Indiana Res & Tech Corp glucagon / glp-1 receptor coagonists
EA031230B1 (en) 2011-06-22 2018-12-28 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн Glucagon/glp-1 receptor agonists
FI2734552T3 (en) 2011-07-22 2025-02-12 Csl Behring Gmbh Inhibitory anti-factor xii/xiia monoclonal antibodies and their uses
UY34317A (en) 2011-09-12 2013-02-28 Genzyme Corp T cell antireceptor antibody (alpha) / ß
KR20130049671A (en) 2011-11-04 2013-05-14 한미사이언스 주식회사 Method for preparation of biological active polypeptide conjugate
CA2847246A1 (en) 2011-11-17 2013-05-23 Indiana University Research And Technology Corporation Glucagon superfamily peptides exhibiting glucocorticoid receptor activity
EP2623110A1 (en) 2012-01-31 2013-08-07 CSL Behring GmbH Factor XII inhibitors for the treatment of neurological inflammatory disorders
PL2814502T3 (en) 2012-02-15 2018-02-28 Csl Behring Gmbh Von willebrand factor variants having improved factor viii binding affinity
RU2015101697A (en) 2012-06-21 2016-08-10 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн GLUCAGON ANALOGUES WITH GIP RECEPTOR ACTIVITY
EP2872534B1 (en) 2012-07-13 2018-08-08 Roche Glycart AG Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases
US9790268B2 (en) 2012-09-12 2017-10-17 Genzyme Corporation Fc containing polypeptides with altered glycosylation and reduced effector function
SI2895513T1 (en) * 2012-09-12 2018-11-30 Genzyme Corporation Fc containing polypeptides with altered glycosylation and reduced effector function
DK3115372T3 (en) 2012-11-27 2019-06-11 Biomarin Pharm Inc TARGETED THERAPEUTIC LYSOSOMAL ENZYMFUSION PROTEINS AND USES THEREOF
US9474803B2 (en) 2012-11-27 2016-10-25 Alteogen Inc. Composition for stabilizing fusion protein in which protein and FC domain are fused
JP6636334B2 (en) 2013-03-08 2020-01-29 ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー Treatment and prevention of remote ischemia-reperfusion injury
IL289918B2 (en) 2013-03-11 2025-07-01 Genzyme Corp Target site for drug-antibody conjugate through glycoengineering
WO2014158900A1 (en) 2013-03-14 2014-10-02 Indiana University Research And Technology Corporation Insulin-incretin conjugates
US9546203B2 (en) * 2013-03-14 2017-01-17 Amgen Inc. Aglycosylated Fc-containing polypeptides with cysteine substitutions
ES2657291T3 (en) 2013-04-22 2018-03-02 Csl Ltd. A covalent complex of von Willebrand factor and factor VIII associated by a disulfide bridge
US20160166660A1 (en) 2013-06-28 2016-06-16 Csl Behring Gmbh Combination therapy using a factor xii inhibitor and a c-1 inhibitor
CN103408669B (en) * 2013-08-01 2016-01-20 江苏泰康生物医药有限公司 GLP-1 analog fusion, and its production and use
CN104592381A (en) * 2013-10-31 2015-05-06 江苏万邦生化医药股份有限公司 Preparation method of liraglutide intermediate polypeptide
WO2015138278A1 (en) 2014-03-11 2015-09-17 Novartis Ag Methods of treating metabolic disorders associated with lipodystrophies and defects in insulin production or signaling
US10995148B2 (en) 2014-03-19 2021-05-04 Genzyme Corporation Site-specific glycoengineering of targeting moieties
MY192248A (en) * 2014-03-31 2022-08-10 Hanmi Pharm Ind Co Ltd Method for improving solubility of protein and peptide by using immunoglobulin fc fragment linkage
BR112016029624A2 (en) 2014-06-18 2017-10-24 Csl Behring Gmbh therapy using a factor xii inhibitor in a neurotraumatic disorder
EP3164150B1 (en) 2014-07-02 2020-11-04 CSL Behring Lengnau AG Modified von willebrand factor
MX378790B (en) 2014-07-21 2025-03-10 Delinia Inc MOLECULES THAT SELECTIVELY ACTIVATE REGULATORY T CELLS FOR THE TREATMENT OF AUTOIMMUNE DISEASES.
SG11201700629TA (en) 2014-08-11 2017-02-27 Delinia Inc Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases
ES2822994T3 (en) 2014-09-24 2021-05-05 Univ Indiana Res & Tech Corp Incretin-insulin conjugates
CN104293834B (en) * 2014-10-11 2018-03-23 上海兴迪金生物技术有限公司 GLP 1 or its analog and antibody Fc fragment fusion protein preparation method
HUE044783T2 (en) 2014-12-23 2019-11-28 Novo Nordisk As Fgf21 derivatives and uses thereof
KR101825048B1 (en) * 2014-12-31 2018-02-05 주식회사 제넥신 Fusion Polypeptide Comprising GLP and Immunoglobulin Hybrid Fc and use thereof
IL283764B2 (en) 2015-04-10 2024-01-01 Amgen Inc Interleukin for the expansion of myotonic control T-2 cells
AR105616A1 (en) 2015-05-07 2017-10-25 Lilly Co Eli FUSION PROTEINS
EP4089109A3 (en) 2015-05-22 2023-03-01 CSL Behring Lengnau AG Methods for preparing modified von willebrand factor
BR112017023785A2 (en) 2015-05-22 2018-07-17 Csl Behring Recombinant Facility Ag Truncated von willebrand factor polypeptides to treat hemophilia
TWI622596B (en) 2015-10-26 2018-05-01 美國禮來大藥廠 Glucagon receptor agonist
KR102668200B1 (en) 2015-10-28 2024-05-23 주식회사유한양행 Long-acting fgf21 fusion proteins and pharmaceutical composition comprising the same
KR102670157B1 (en) 2015-10-28 2024-05-29 주식회사유한양행 Dual function proteins and pharmaceutical composition comprising the same
EP3184149A1 (en) 2015-12-23 2017-06-28 Julius-Maximilians-Universität Würzburg Soluble glycoprotein v for treating thrombotic diseases
SG11201805255TA (en) 2015-12-23 2018-07-30 Amgen Inc Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (gipr) in combination with glp-1 agonists
RU2018128582A (en) 2016-01-07 2020-02-11 Цсл Беринг Ленгнау Аг MUTED CROPPED VILLEBRAND BACKGROUND FACTOR
DK3400238T3 (en) 2016-01-07 2021-07-26 CSL Behring Lengnau AG MUTERATED BY WILLEBRAND FACTOR
US20170204154A1 (en) 2016-01-20 2017-07-20 Delinia, Inc. Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases
KR20230136687A (en) 2016-04-06 2023-09-26 시에스엘 리미티드 Method of treating atherosclerosis
CN109071634A (en) 2016-04-26 2018-12-21 R.P.谢勒技术有限责任公司 Antibody coupling matter and its preparation and application
US10336812B2 (en) * 2016-05-10 2019-07-02 Janssen Biotech, Inc. GDF15 fusion proteins and uses thereof
CN106279437B (en) 2016-08-19 2017-10-31 安源医药科技(上海)有限公司 Hyperglycosylated human coagulation factor VIII fusion proteins and preparation method thereof and purposes
CN107759694B (en) 2016-08-19 2023-01-13 安源医药科技(上海)有限公司 Bispecific antibody, preparation method and application thereof
US11123438B2 (en) 2016-08-19 2021-09-21 Ampsource Biopharma Shanghai Inc. Linker peptide for constructing fusion protein
WO2018089420A1 (en) 2016-11-08 2018-05-17 Delinia, Inc. Il-2 variants for the treatment of autoimmune diseases
CN110121355B (en) 2016-11-10 2023-09-12 株式会社柳韩洋行 Pharmaceutical compositions containing fusion proteins for preventing or treating hepatitis, liver fibrosis and cirrhosis
SG11201903954WA (en) 2016-11-11 2019-05-30 CSL Behring Lengnau AG Truncated von willebrand factor polypeptides for extravascular administration in the treatment or prophylaxis of a blood coagulation disorder
US11814421B2 (en) 2016-11-11 2023-11-14 CSL Behring Lengnau AG Truncated von Willebrand Factor polypeptides for treating hemophilia
EP3351262A1 (en) 2016-12-30 2018-07-25 Istanbul Universitesi Rektorlugu Curaglutide for in treatment of prediabetes, diabetes, obesity and metabolic diseases associated thereto
JOP20190177A1 (en) 2017-01-17 2019-07-16 Amgen Inc Method of treating or ameliorating metabolic disorders using glp-1 receptor agonists conjugated to antagonists for gastric inhibitory peptide receptor (gipr)
CN108570109B (en) 2017-03-14 2022-04-26 广东东阳光药业有限公司 Dual target fusion proteins comprising an immunoglobulin Fc portion
AU2018256256B2 (en) 2017-04-21 2023-02-23 Yuhan Corporation Method for producing dual function proteins and its derivatives
LT3630164T (en) 2017-06-01 2023-10-25 Eli Lilly And Company Dulaglutide for the treatment of chronic kidney disease
AU2018288854B2 (en) 2017-06-20 2025-06-26 Amgen Inc. Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (GIPR) in combination with GLP-1 agonists
CA3263567A1 (en) 2017-06-21 2025-10-30 Amgen Inc. Method of treating or ameliorating metabolic disorders using antagonistic binding proteins for gastric inhibitory peptide receptor (gipr)/glp-1 receptor agonist fusion proteins
WO2018234518A1 (en) 2017-06-22 2018-12-27 CSL Behring Lengnau AG MODULATION OF IMMUNOGENICITY OF FVIII BY VWF TRONQUÉ
JP2020531002A (en) 2017-08-15 2020-11-05 キンドレッド バイオサイエンシズ インコーポレイテッド Veterinary IGG FC mutant
WO2019060653A1 (en) 2017-09-22 2019-03-28 Regeneron Pharmaceuticals, Inc. Glucagon-like peptide 1 receptor agonists and uses thereof
WO2019103875A2 (en) 2017-11-21 2019-05-31 Eli Lilly And Company Methods of using and compositions containing dulaglutide
WO2019119673A1 (en) 2017-12-19 2019-06-27 北京吉源生物科技有限公司 Double gene-modified stem cell and use thereof
US11491235B2 (en) 2017-12-22 2022-11-08 Kb Biomed Inc. Oral gene carrier and use thereof
IL275499B2 (en) 2017-12-22 2024-03-01 Novartis Ag Methods for treating metabolic disorders with FGF21 variants
WO2019140021A1 (en) 2018-01-12 2019-07-18 Eli Lilly And Company Combination therapy
AU2019218147B2 (en) 2018-02-08 2023-06-08 Sunshine Lake Pharma Co., Ltd. FGF21 variant, fusion protein and application thereof
JP2021530533A (en) 2018-07-19 2021-11-11 ディーアンドディー ファーマテック インコーポレイテッド Pharmaceutical composition containing a polypeptide
KR20200135618A (en) 2019-05-23 2020-12-03 ㈜ 디앤디파마텍 Pharmaceutical composition for preventing or treating nonalcoholic fatty liver disease comprising a polypeptide
CN110878127B (en) 2018-09-06 2022-06-28 浙江柏拉阿图医药科技有限公司 Long-acting recombinant GLP1-Fc-CD47 protein and preparation and application thereof
KR20210081389A (en) 2018-10-22 2021-07-01 얀센 파마슈티카 엔.브이. Glucagon-like peptide 1 (GLP1)-growth differentiation factor 15 (GDF15) fusion protein and uses thereof
KR102467349B1 (en) 2018-10-29 2022-11-16 에프. 호프만-라 로슈 아게 antibody formulation
CN111234000B (en) * 2018-11-28 2023-05-26 鲁南制药集团股份有限公司 Ai Saina peptide analogues
CN111269312B (en) * 2018-12-04 2023-05-09 鲁南制药集团股份有限公司 Heterologous fusion protein
CN109836486B (en) * 2019-01-30 2020-09-08 北京双因生物科技有限公司 Fibroblast growth factor 21 variants, fusion proteins thereof, and uses thereof
EP3935075A4 (en) * 2019-03-05 2023-01-18 Sunshine Lake Pharma Co., Ltd. POLYPEPTIDIC MOLECULE AND ITS APPLICATION
EP3934679A1 (en) 2019-03-08 2022-01-12 Amgen Inc. Growth differentiation factor 15 combination therapy
CN113613629A (en) 2019-03-15 2021-11-05 伊莱利利公司 Preserved formulations
WO2020206063A1 (en) 2019-04-03 2020-10-08 Genzyme Corporation Anti-alpha beta tcr binding polypeptides with reduced fragmentation
CA3177693A1 (en) 2019-04-05 2020-10-05 Eli Lilly And Company Therapeutic uses of dulaglutide
KR20200124176A (en) * 2019-04-23 2020-11-02 주식회사 엘지화학 FUSION POLYPEPTIDE COMPRISING Fc REGION OF IMMUNOGLOBULIN AND GDF15
US20220211808A1 (en) 2019-05-17 2022-07-07 Universitaet Zuerich Haptoglobin for use in treating an adverse secondary neurological outcome following a haemorrhagic stroke
KR20220029733A (en) 2019-07-04 2022-03-08 체에스엘 베링 렝나우 아게 truncated von Willebrand factor (VWF) to increase the in vitro stability of coagulation factor VIII
CN114555792A (en) 2019-10-15 2022-05-27 伊莱利利公司 Recombinant engineered, lipase/esterase deficient mammalian cell lines
WO2021094344A1 (en) 2019-11-11 2021-05-20 CSL Behring Lengnau AG Polypeptides for inducing tolerance to factor viii
CN115322794B (en) 2020-01-11 2025-09-19 北京质肽生物医药科技有限公司 Conjugate of fusion protein of GLP-1 and FGF21
US11981718B2 (en) 2020-05-27 2024-05-14 Ampsource Biopharma Shanghai Inc. Dual-function protein for lipid and blood glucose regulation
EP4200429A1 (en) 2020-08-24 2023-06-28 The Trustees of The University of Pennsylvania Viral vectors encoding glp-1 receptor agonist fusions and uses thereof in treating metabolic diseases
CN114106194B (en) * 2020-08-31 2024-01-16 中国科学院天津工业生物技术研究所 Fusion protein for treating diabetes and/or obesity
CN116568327A (en) 2020-11-20 2023-08-08 德国杰特贝林生物制品有限公司 Methods of treating antibody-mediated rejection
CN114685644A (en) 2020-12-29 2022-07-01 苏州康宁杰瑞生物科技有限公司 Human GLP-1 polypeptide variant and application thereof
KR20230142569A (en) 2021-02-01 2023-10-11 체에스엘 베링 아게 Methods for Treating or Preventing Secondary Neurological Adverse Events After Hemorrhagic Stroke
CN117321074A (en) 2021-05-07 2023-12-29 瑞士杰特贝林生物制品有限公司 Expression system for production of recombinant haptoglobin (Hp) beta chain
TW202317607A (en) 2021-07-06 2023-05-01 大陸商蘇州康寧杰瑞生物科技有限公司 Fusion protein and its applications thereof
CA3224743A1 (en) 2021-07-14 2023-01-19 Beijing Ql Biopharmaceutical Co., Ltd. Fusion polypeptides for metabolic disorders
AR129357A1 (en) 2022-05-18 2024-08-14 Protomer Tech Inc BORON-CONTAINING AROMATIC COMPOUNDS AND RELATED INSULIN ANALOGUES
CN114774496B (en) * 2022-06-21 2022-10-04 北京惠之衡生物科技有限公司 Method for preparing GLP-1 analogue through high-density fermentation
KR20250058762A (en) 2022-09-02 2025-04-30 체에스엘 베링 아게 Haptoglobin for use in treating or preventing excessive erectile response or erectile dysfunction
KR20250075642A (en) 2022-09-21 2025-05-28 리제너론 파아마슈티컬스, 인크. How to treat obesity, diabetes and liver dysfunction
WO2024068848A1 (en) 2022-09-28 2024-04-04 Zealand Pharma A/S Methods for treating obesity
WO2024123812A1 (en) 2022-12-05 2024-06-13 Shattuck Labs, Inc. Fusion proteins for the treatment of cardiometabolic diseases
EP4638483A1 (en) 2022-12-22 2025-10-29 LifeArc Galanin-2 receptor agonists
CN120917038A (en) 2023-03-23 2025-11-07 伊莱利利公司 Method for producing Fc-containing protein
WO2025069009A1 (en) 2023-09-29 2025-04-03 Graviton Bioscience Bv Rock2 inhibitors in the treatment of obesity
WO2025122835A2 (en) 2023-12-08 2025-06-12 Eli Lilly And Company Methods of producing fc-containing proteins
US20250270274A1 (en) * 2024-02-26 2025-08-28 Serpentide Inc. Super long-lasting glp1 or glp1/gip analogue drug for type-2 diabetes and obesity
WO2025257801A1 (en) 2024-06-13 2025-12-18 CSL Innovation Pty Ltd Heme-binding protein for the treatment of ischemia-reperfusion injury (iri)

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
NZ201705A (en) 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4943529A (en) 1982-05-19 1990-07-24 Gist-Brocades Nv Kluyveromyces as a host strain
AU3145184A (en) 1983-08-16 1985-02-21 Zymogenetics Inc. High expression of foreign genes in schizosaccharomyces pombe
US4879231A (en) 1984-10-30 1989-11-07 Phillips Petroleum Company Transformation of yeasts of the genus pichia
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
AU600575B2 (en) 1987-03-18 1990-08-16 Sb2, Inc. Altered antibodies
US5010182A (en) 1987-07-28 1991-04-23 Chiron Corporation DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides
AU4005289A (en) 1988-08-25 1990-03-01 Smithkline Beecham Corporation Recombinant saccharomyces
FR2646437B1 (en) 1989-04-28 1991-08-30 Transgene Sa NOVEL DNA SEQUENCES, THEIR APPLICATION AS A SEQUENCE ENCODING A SIGNAL PEPTIDE FOR THE SECRETION OF MATURE PROTEINS BY RECOMBINANT YEASTS, EXPRESSION CASSETTES, PROCESSED YEASTS AND PROCESS FOR PREPARING THE SAME
DE68927344T2 (en) 1989-04-28 1997-02-20 Rhein Biotech Proz & Prod Gmbh Yeast cells of the genus Schwanniomyces
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
FR2649120B1 (en) 1989-06-30 1994-01-28 Cayla NOVEL STRAIN AND ITS MUTANTS OF FILAMENTOUS MUSHROOMS, PROCESS FOR PRODUCING RECOMBINANT PROTEINS USING SAID STRAIN, AND STRAINS AND PROTEINS OBTAINED BY SAID METHOD
EP0669929B1 (en) 1992-11-13 2007-01-03 Immunex Corporation Elk ligand, a cytokine
CA2196200A1 (en) * 1994-07-29 1996-02-15 Michael Joseph Browne Novel compounds
GB9511935D0 (en) 1995-06-13 1995-08-09 Smithkline Beecham Plc Novel compound
US5723125A (en) 1995-12-28 1998-03-03 Tanox Biosystems, Inc. Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
US6750334B1 (en) 1996-02-02 2004-06-15 Repligen Corporation CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor
US6006753A (en) 1996-08-30 1999-12-28 Eli Lilly And Company Use of GLP-1 or analogs to abolish catabolic changes after surgery
US6277819B1 (en) 1996-08-30 2001-08-21 Eli Lilly And Company Use of GLP-1 or analogs in treatment of myocardial infarction
UA65549C2 (en) 1996-11-05 2004-04-15 Елі Ліллі Енд Компані Use of glucagon-like peptides such as glp-1, glp-1 analog, or glp-1 derivative in methods and compositions for reducing body weight
US6190909B1 (en) 1997-04-17 2001-02-20 Millennium Pharmaceuticals, Inc. TH2-specific gene
SE9802080D0 (en) 1998-06-11 1998-06-11 Hellstroem Pharmaceutical composition for the treatment of functional dyspepsia and / or irritable bowel syndrome and new use of substances therein
EP1100530B1 (en) 1998-07-31 2003-10-08 Novo Nordisk A/S In-vitro stimulation of beta cell proliferation
MY155270A (en) 1998-09-24 2015-09-30 Lilly Co Eli Use of glp-1 or analogs in treatment of stroke
US6376653B1 (en) 1998-09-28 2002-04-23 Smithkline Beecham Plc Tie2 antagonist antibodies
EP1180121B9 (en) 1999-05-17 2004-09-08 Conjuchem, Inc. Long lasting insulinotropic peptides
AU6479101A (en) 2000-06-16 2002-01-02 Lilly Co Eli Glucagon-like peptide-1 analogs
UA93662C2 (en) * 2000-12-07 2011-03-10 Эли Лилли Энд Компани Heterologous fusion glucagon-like protein and use thereof for the preparation of medicinal agent for treating patients with overweight and/or non-insulin dependent diabetes mellitus
US6992174B2 (en) 2001-03-30 2006-01-31 Emd Lexigen Research Center Corp. Reducing the immunogenicity of fusion proteins
US6900292B2 (en) 2001-08-17 2005-05-31 Lee-Hwei K. Sun Fc fusion proteins of human erythropoietin with increased biological activities
ES2425738T3 (en) 2001-12-21 2013-10-17 Human Genome Sciences, Inc. Albumin Fusion Proteins
EA008831B1 (en) * 2003-06-12 2007-08-31 Эли Лилли Энд Компани SLIP PROTEINS OF GLP-1 ANALOGUES

Also Published As

Publication number Publication date
LTPA2015007I1 (en) 2015-03-25
FR15C0010I1 (en) 2015-03-13
AU2004251145A1 (en) 2005-01-06
BRPI0411132A (en) 2006-07-18
CY2015002I2 (en) 2017-04-05
HUS1500024I1 (en) 2017-04-28
CN1802386A (en) 2006-07-12
TW200507870A (en) 2005-03-01
NZ543292A (en) 2008-04-30
KR20060022262A (en) 2006-03-09
EP1641823A2 (en) 2006-04-05
KR100758755B1 (en) 2007-09-14
LTC1641823I2 (en) 2016-12-12
SI1641823T1 (en) 2011-12-30
ATE525395T1 (en) 2011-10-15
WO2005000892A3 (en) 2005-03-03
EP1641823B1 (en) 2011-09-21
BE2015C007I2 (en) 2023-08-09
HK1149566A1 (en) 2011-10-07
JP4629047B2 (en) 2011-02-09
BRPI0411132B1 (en) 2016-12-13
UA87458C2 (en) 2009-07-27
US20070036806A1 (en) 2007-02-15
EA200600015A1 (en) 2006-06-30
AR044776A1 (en) 2005-10-05
AU2004251145C1 (en) 2011-04-14
CN101974090B (en) 2015-06-17
US7452966B2 (en) 2008-11-18
EA008831B1 (en) 2007-08-31
IL171926A0 (en) 2006-04-10
CN1802386B (en) 2010-12-15
WO2005000892A2 (en) 2005-01-06
CA2528591A1 (en) 2005-01-06
BRPI0411132B8 (en) 2021-05-25
MXPA05013565A (en) 2006-03-09
IL171926A (en) 2010-12-30
PL1641823T3 (en) 2012-02-29
CA2528591C (en) 2013-01-08
CN101974090A (en) 2011-02-16
AU2004251145B2 (en) 2010-09-09
HRP20110714T1 (en) 2011-11-30
ES2371072T3 (en) 2011-12-27
DK1641823T3 (en) 2011-12-12
US8273854B2 (en) 2012-09-25
CY2015002I1 (en) 2015-11-04
CY1111991T1 (en) 2015-11-04
JP2007536902A (en) 2007-12-20
EP2368909A1 (en) 2011-09-28
PT1641823E (en) 2011-11-08
US20090074769A1 (en) 2009-03-19

Similar Documents

Publication Publication Date Title
FR15C0010I2 (en) GLP-1 ANALOGUE HYBRID PROTEINS
FR17C1024I2 (en) FACTOR VIII POLYPEPTIDE
MA28857B1 (en) PIPERAZINYL-PYRIDINE BIARYLIC SUBSTITUTED ANALOGUES
DK1478328T3 (en) Bioactive keratin peptides
DK1819670T3 (en) 12-aryl-prostaglandin analogues
MA28841B1 (en) TETRAPEPTITIIC ANALOGS
EP1642377A4 (en) VIBRATOR
EP1514106A4 (en) TARGETED THERAPEUTIC PROTEINS
DE602005015131D1 (en) INTERLEUKIN-15-ANTAGONISTIC PEPTIDE
ATA19522003A (en) GAG BINDING PROTEINS
NO20054669D0 (en) Substituted quinobenzoxazine analogues
ATE455555T1 (en) GLP-1 ANALOGUE
EP1671629A4 (en) BETA-DEFENSINE SECRETION PROMOTER
EP1735335A4 (en) Cell-destroying peptides
DK1809660T3 (en) THYMUS-SPECIFIC PROTEIN
DE602005012757D1 (en) Antibacterial peptide
DK1664096T3 (en) Antimicrobial peptides
EP1682572A4 (en) EXPRESSION OF PROTEINS
ITMI20031144A0 (en) COLCHICOSIDE ANALOGUES
DE602004018794D1 (en) ANTIMICROBIAL PEPTIDES
EP1968623A4 (en) PEPTIDES INDUCING BACTERIOCIN
ITMI20041440A1 (en) ANALOGUE PEPTIDES OF PTH-1-11
DK1625148T3 (en) peptide Complex
FI20050753L (en) New peptides
DE602004022136D1 (en) LEUKOCYTES STIMULATING PEPTIDES