FR1540942A - Steroid derivatives substituted in positions 11 and 17 having an aromatic ring and method of preparation - Google Patents

Steroid derivatives substituted in positions 11 and 17 having an aromatic ring and method of preparation

Info

Publication number
FR1540942A
FR1540942A FR98154A FR98154A FR1540942A FR 1540942 A FR1540942 A FR 1540942A FR 98154 A FR98154 A FR 98154A FR 98154 A FR98154 A FR 98154A FR 1540942 A FR1540942 A FR 1540942A
Authority
FR
France
Prior art keywords
positions
preparation
aromatic ring
derivatives substituted
steroid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR98154A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR64481A priority Critical patent/FR5519M/fr
Priority to FR75528A priority patent/FR1514122A/en
Priority to FR86879A priority patent/FR6021M/fr
Priority to FR91611A priority patent/FR6030M/fr
Priority to FR96848A priority patent/FR6182M/fr
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR98154A priority patent/FR1540942A/en
Priority to GB25315/67A priority patent/GB1152226A/en
Priority to GB25314/67A priority patent/GB1151404A/en
Priority to US643061A priority patent/US3526648A/en
Priority to BE699394D priority patent/BE699394A/xx
Priority to BE699393D priority patent/BE699393A/xx
Priority to YU1125/67A priority patent/YU33880B/en
Priority to SE14236/69A priority patent/SE361881B/xx
Priority to SE07863/67A priority patent/SE335980B/xx
Priority to SE07862/67A priority patent/SE335979B/xx
Priority to SU1250885A priority patent/SU432714A3/ru
Priority to DK294467AA priority patent/DK121857B/en
Priority to ES341435A priority patent/ES341435A1/en
Priority to SU1161494A priority patent/SU483828A3/en
Priority to DK294567AA priority patent/DK119925B/en
Priority to NL6707903A priority patent/NL6707903A/xx
Priority to DE1618830A priority patent/DE1618830C3/en
Priority to CH806367A priority patent/CH474495A/en
Priority to NL6707906A priority patent/NL6707906A/xx
Priority to CH567869A priority patent/CH482660A/en
Priority to AT1252868A priority patent/AT290023B/en
Priority to DE19671793738 priority patent/DE1793738C3/en
Priority to CH567769A priority patent/CH482663A/en
Priority to CH806467A priority patent/CH475965A/en
Priority to AT532367A priority patent/AT301037B/en
Priority to DE19671618829 priority patent/DE1618829C/en
Priority to AT532267A priority patent/AT279815B/en
Priority to CH450769A priority patent/CH490361A/en
Priority to IL28113A priority patent/IL28113A/en
Priority to IL28112A priority patent/IL28112A/en
Priority to ES344805A priority patent/ES344805A1/en
Priority to YU1758/67A priority patent/YU33882B/en
Priority to ES348057A priority patent/ES348057A1/en
Priority to YU2408/67A priority patent/YU33725B/en
Priority to YU109/68A priority patent/YU34050B/en
Priority to ES350987A priority patent/ES350987A1/en
Priority to YU455/68A priority patent/YU33883B/en
Priority to YU545/68A priority patent/YU33972B/en
Priority to ES351368A priority patent/ES351368A1/en
Application granted granted Critical
Publication of FR1540942A publication Critical patent/FR1540942A/en
Priority to US852905A priority patent/US3579545A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR98154A 1966-06-07 1967-03-09 Steroid derivatives substituted in positions 11 and 17 having an aromatic ring and method of preparation Expired FR1540942A (en)

Priority Applications (45)

Application Number Priority Date Filing Date Title
FR64481A FR5519M (en) 1966-06-07 1966-06-07
FR75528A FR1514122A (en) 1966-06-07 1966-09-07 Aromatic α-ring-substituted steroid derivatives and method of preparation
FR86879A FR6021M (en) 1966-06-07 1966-12-09
FR91611A FR6030M (en) 1966-06-07 1967-01-18
FR96848A FR6182M (en) 1966-06-07 1967-02-28
FR98154A FR1540942A (en) 1966-06-07 1967-03-09 Steroid derivatives substituted in positions 11 and 17 having an aromatic ring and method of preparation
GB25314/67A GB1151404A (en) 1966-06-07 1967-06-01 Novel Gona-1,3,5(10)-Trienes, Processes for their Preparation, and Compositions incorporating them
GB25315/67A GB1152226A (en) 1966-06-07 1967-06-01 Novel Gona-1,3,5(10)-Trienes, processes for their preparation, and compositions incorporating them
US643061A US3526648A (en) 1966-06-07 1967-06-02 Novel 11beta-alkoxy-delta**1,3,5(10)-gonatrienes
BE699394D BE699394A (en) 1966-06-07 1967-06-02
BE699393D BE699393A (en) 1966-06-07 1967-06-02
YU1125/67A YU33880B (en) 1966-06-07 1967-06-03 Process for preparing estra-1,3,5-(10)-triens oxidized in positions 3 and 17
SE14236/69A SE361881B (en) 1966-06-07 1967-06-05
SE07863/67A SE335980B (en) 1966-06-07 1967-06-05
SE07862/67A SE335979B (en) 1966-06-07 1967-06-05
DK294467AA DK121857B (en) 1966-06-07 1967-06-06 Analogous process for the preparation of 11β-alkyloxy-13β-alkylgona-1,3,5, (10) -triene derivatives.
ES341435A ES341435A1 (en) 1966-06-07 1967-06-06 Novel 11beta-alkoxy-delta**1,3,5(10)-gonatrienes
SU1161494A SU483828A3 (en) 1966-06-07 1967-06-06 The method of obtaining derivatives of steroids with aromatic core and substituted in position 11
DK294567AA DK119925B (en) 1966-06-07 1967-06-06 Analogous process for the preparation of 3,17β-dihydroxy-11β-alkyloxy-13β-alkylgona-1,3,5 (10) -trienes or ethers or esters thereof.
SU1250885A SU432714A3 (en) 1966-06-07 1967-06-06
NL6707906A NL6707906A (en) 1966-06-07 1967-06-07
CH806367A CH474495A (en) 1966-06-07 1967-06-07 Process for the preparation of steroid derivatives with an aromatic A ring, substituted in position 11
NL6707903A NL6707903A (en) 1966-06-07 1967-06-07
CH567869A CH482660A (en) 1966-06-07 1967-06-07 Process for the preparation of steroid derivatives with an aromatic A ring, substituted in position 11
AT1252868A AT290023B (en) 1966-06-07 1967-06-07 Process for the preparation of new 3-OA-11β-OB-13β-C-17α-R-17β-OE-gona-1,3,5 (10) -trienes
DE19671793738 DE1793738C3 (en) 1966-09-07 1967-06-07 3-0A-11 beta-OB-17alpha-R-17beta-OH-östra-1,3,5 (10) -trlene and medicinal products containing them
CH567769A CH482663A (en) 1966-06-07 1967-06-07 Process for the preparation of steroid derivatives with an aromatic A ring, substituted in position 11
CH806467A CH475965A (en) 1966-06-07 1967-06-07 Process for the preparation of steroid derivatives with an aromatic A ring, substituted in positions 11 and 17
AT532367A AT301037B (en) 1966-06-07 1967-06-07 Process for the preparation of new 3-OA-11β-OB-13β-C-17α-R-17β-OE-gona-1,3,5 (10) -trienes
DE19671618829 DE1618829C (en) 1966-09-07 1967-06-07 Process for the production of 3 OA 11 beta OB 13beta C 17alpha R 17beta OE gona 1,3,5 (10) tons
AT532267A AT279815B (en) 1966-06-07 1967-06-07 Process for making new gona-1,3,5 (10) -trienes
CH450769A CH490361A (en) 1966-06-07 1967-06-07 Process for the preparation of steroid derivatives with an aromatic A ring, substituted in positions 11 and 17
DE1618830A DE1618830C3 (en) 1966-06-07 1967-06-07 11 beta-OB-13beta-C-gona-1,3,5 (10) -trienes containing oxygen in the 3 and 17 positions and process for their preparation
IL28113A IL28113A (en) 1966-06-07 1967-06-08 11beta-alkoxy-17alpha-substituted-gona 1,3,5(10)-trienes and preparation processes
IL28112A IL28112A (en) 1966-06-07 1967-06-08 11beta-alkoxy-estra 1,3,5(10)-trienes and their preparation
ES344805A ES344805A1 (en) 1966-06-07 1967-09-06 Novel 11beta-alkoxy-delta**1,3,5(10)-gonatrienes
YU1758/67A YU33882B (en) 1966-06-07 1967-09-07 Process for preparing estradiol derivatives
ES348057A ES348057A1 (en) 1966-06-07 1967-12-07 Novel 11beta-alkoxy-delta**1,3,5(10)-gonatrienes
YU2408/67A YU33725B (en) 1966-06-07 1967-12-08 Process for preparing 3,17 oxidized esters of1,3,5(10)-trienes
YU109/68A YU34050B (en) 1966-06-07 1968-01-17 Process for preparing 3817beta-dihydroxy-11beta-ethoxy-estra-1,2,3(10)-trienes
ES350987A ES350987A1 (en) 1966-06-07 1968-02-27 Novel 11beta-alkoxy-delta**1,3,5(10)-gonatrienes
YU455/68A YU33883B (en) 1966-06-07 1968-02-27 Process for preparing 3,17-dihydro-11beta-methoxy-17delta-ethinyl-estra-1,3,5-(10)-trienes
YU545/68A YU33972B (en) 1966-06-07 1968-03-08 Process for preparing 3,17beta-dihydroxy-11 beta-ethoxy-17 delta-ethynyl-estra-1,3,5(10)-triene
ES351368A ES351368A1 (en) 1966-06-07 1968-03-08 Novel 11beta-alkoxy-delta**1,3,5(10)-gonatrienes
US852905A US3579545A (en) 1966-06-07 1969-08-25 Novel 11beta-alkoxy gona-1,3,5(10)-trienes

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
FR64481A FR5519M (en) 1966-06-07 1966-06-07
FR75528A FR1514122A (en) 1966-06-07 1966-09-07 Aromatic α-ring-substituted steroid derivatives and method of preparation
FR86879A FR6021M (en) 1966-06-07 1966-12-09
FR91611A FR6030M (en) 1966-06-07 1967-01-18
FR96848A FR6182M (en) 1966-06-07 1967-02-28
FR98154A FR1540942A (en) 1966-06-07 1967-03-09 Steroid derivatives substituted in positions 11 and 17 having an aromatic ring and method of preparation

Publications (1)

Publication Number Publication Date
FR1540942A true FR1540942A (en) 1968-10-04

Family

ID=27546052

Family Applications (6)

Application Number Title Priority Date Filing Date
FR64481A Expired FR5519M (en) 1966-06-07 1966-06-07
FR75528A Expired FR1514122A (en) 1966-06-07 1966-09-07 Aromatic α-ring-substituted steroid derivatives and method of preparation
FR86879A Expired FR6021M (en) 1966-06-07 1966-12-09
FR91611A Expired FR6030M (en) 1966-06-07 1967-01-18
FR96848A Expired FR6182M (en) 1966-06-07 1967-02-28
FR98154A Expired FR1540942A (en) 1966-06-07 1967-03-09 Steroid derivatives substituted in positions 11 and 17 having an aromatic ring and method of preparation

Family Applications Before (5)

Application Number Title Priority Date Filing Date
FR64481A Expired FR5519M (en) 1966-06-07 1966-06-07
FR75528A Expired FR1514122A (en) 1966-06-07 1966-09-07 Aromatic α-ring-substituted steroid derivatives and method of preparation
FR86879A Expired FR6021M (en) 1966-06-07 1966-12-09
FR91611A Expired FR6030M (en) 1966-06-07 1967-01-18
FR96848A Expired FR6182M (en) 1966-06-07 1967-02-28

Country Status (14)

Country Link
US (2) US3526648A (en)
AT (3) AT301037B (en)
BE (2) BE699393A (en)
CH (3) CH475965A (en)
DE (1) DE1618830C3 (en)
DK (2) DK121857B (en)
ES (5) ES341435A1 (en)
FR (6) FR5519M (en)
GB (2) GB1151404A (en)
IL (2) IL28112A (en)
NL (2) NL6707906A (en)
SE (2) SE335979B (en)
SU (2) SU483828A3 (en)
YU (6) YU33880B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2323615A1 (en) * 1972-05-10 1973-11-22 Roussel Uclaf ZOOTECHNICAL COMPOSITIONS

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2140258B1 (en) * 1971-06-07 1974-08-23 Roussel Uclaf
US3906096A (en) * 1971-11-23 1975-09-16 Roussel Uclaf Novel 11{62 -alkoxy steroids
NL7613248A (en) * 1976-11-26 1978-05-30 Akzo Nv PROCEDURE FOR PREPARING NEW STEROID ESTERS.
FR2401173A1 (en) * 1977-06-27 1979-03-23 Roussel Uclaf NEW STEROIDS, THEIR PREPARATION PROCESS AND THEIR APPLICATION IN THE SYNTHESIS OF STEROIDS TRADEMARKS WITH TRITIUM
US4668668A (en) * 1984-03-20 1987-05-26 Wayne State University Compositions inhibiting murine MXT ductal carcinoma
US4636496A (en) * 1984-03-20 1987-01-13 Wayne State University Compositions inhibiting murine MXT ductal carcinoma
US4568673A (en) * 1984-03-20 1986-02-04 Wayne State University Compositions inhibiting murine MXT ductal carcinoma
US4705783A (en) * 1985-06-25 1987-11-10 Sri International 9α, 11β-substituted and 11β-substituted estranes
AU2001296872A1 (en) * 2000-09-14 2002-03-26 Accelerated Pharmaceuticals, Inc. Method of making 7alpha-methyl-11beta-methoxy estradiol and related compounds with estrogenic activity
PT2782584T (en) 2011-11-23 2021-09-02 Therapeuticsmd Inc Natural combination hormone replacement formulations and therapies
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
MX2016014281A (en) 2014-05-22 2017-02-22 Therapeuticsmd Inc Natural combination hormone replacement formulations and therapies.
EP3224230B1 (en) 2014-11-26 2020-01-08 The Regents of The University of California Estrogen receptor modulators
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
KR20180126582A (en) 2016-04-01 2018-11-27 쎄러퓨틱스엠디, 인코퍼레이티드 Steroid hormone pharmaceutical composition
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2323615A1 (en) * 1972-05-10 1973-11-22 Roussel Uclaf ZOOTECHNICAL COMPOSITIONS

Also Published As

Publication number Publication date
YU240867A (en) 1977-08-31
YU33725B (en) 1978-02-28
NL6707906A (en) 1968-03-08
DK121857B (en) 1971-12-13
IL28113A (en) 1973-08-29
ES344805A1 (en) 1968-11-01
SE335980B (en) 1971-06-21
YU33882B (en) 1978-06-30
US3579545A (en) 1971-05-18
YU33972B (en) 1978-09-08
NL6707903A (en) 1967-12-08
DE1618829A1 (en) 1971-01-14
GB1151404A (en) 1969-05-07
FR6021M (en) 1968-05-13
YU175867A (en) 1977-12-31
ES341435A1 (en) 1968-07-01
CH474495A (en) 1969-06-30
YU33883B (en) 1978-06-30
BE699393A (en) 1967-12-04
FR6030M (en) 1968-05-13
GB1152226A (en) 1969-05-14
FR6182M (en) 1968-07-15
YU112567A (en) 1977-12-31
AT279815B (en) 1970-03-25
CH490361A (en) 1970-05-15
DK119925B (en) 1971-03-15
CH475965A (en) 1969-07-31
DE1618830A1 (en) 1972-04-13
YU33880B (en) 1978-06-30
DE1618830C3 (en) 1975-02-20
ES350987A1 (en) 1969-05-16
SU432714A3 (en) 1974-06-15
IL28112A (en) 1973-08-29
YU10968A (en) 1978-05-15
DE1793738B2 (en) 1975-11-27
DE1793738A1 (en) 1973-01-11
BE699394A (en) 1967-12-04
YU54568A (en) 1978-02-28
SU483828A3 (en) 1975-09-05
FR1514122A (en) 1968-02-23
AT301037B (en) 1972-08-25
AT290023B (en) 1971-05-10
US3526648A (en) 1970-09-01
YU34050B (en) 1978-10-31
DE1618830B2 (en) 1974-07-04
FR5519M (en) 1967-11-06
ES348057A1 (en) 1969-03-01
YU45568A (en) 1977-12-31
SE335979B (en) 1971-06-21
ES351368A1 (en) 1969-06-01

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