FI98731B - Method for preparing superactive insulin analogs - Google Patents

Method for preparing superactive insulin analogs

Info

Publication number
FI98731B
FI98731B FI900249A FI900249A FI98731B FI 98731 B FI98731 B FI 98731B FI 900249 A FI900249 A FI 900249A FI 900249 A FI900249 A FI 900249A FI 98731 B FI98731 B FI 98731B
Authority
FI
Finland
Prior art keywords
preparing
insulin analogs
superactive insulin
superactive
analogs
Prior art date
Application number
FI900249A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI900249A0 (en
FI98731C (en
Inventor
Panayotis G Katsoyannis
Gerald P Schwartz
Original Assignee
Sinai School Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sinai School Medicine filed Critical Sinai School Medicine
Publication of FI900249A0 publication Critical patent/FI900249A0/en
Application granted granted Critical
Publication of FI98731B publication Critical patent/FI98731B/en
Publication of FI98731C publication Critical patent/FI98731C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
FI900249A 1987-07-17 1990-01-16 Process for Preparation of Superactive Insulin Analogs FI98731C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/074,558 US4992418A (en) 1987-07-17 1987-07-17 Superactive human insulin analogue-[10-Aspartic Acid-B]Human Insulin
US7455887 1987-07-17
US8802289 1988-07-07
PCT/US1988/002289 WO1989000580A1 (en) 1987-07-17 1988-07-07 Superactive human insulin analogues

Publications (3)

Publication Number Publication Date
FI900249A0 FI900249A0 (en) 1990-01-16
FI98731B true FI98731B (en) 1997-04-30
FI98731C FI98731C (en) 1997-08-11

Family

ID=22120214

Family Applications (1)

Application Number Title Priority Date Filing Date
FI900249A FI98731C (en) 1987-07-17 1990-01-16 Process for Preparation of Superactive Insulin Analogs

Country Status (10)

Country Link
US (1) US4992418A (en)
EP (1) EP0382732B1 (en)
JP (1) JP2729498B2 (en)
KR (1) KR970009353B1 (en)
AU (1) AU616131B2 (en)
DE (1) DE3887338T2 (en)
DK (1) DK13990D0 (en)
FI (1) FI98731C (en)
HU (1) HU205145B (en)
WO (1) WO1989000580A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE101620T1 (en) * 1988-06-23 1994-03-15 Hoechst Ag MINI-PROINSULIN, ITS PREPARATION AND USE.
DK0586589T3 (en) * 1991-05-24 1997-09-22 Amylin Pharmaceuticals Inc Amylin or amylin analogue, possibly containing insulin, for the treatment of anorexia and related conditions
CA2071382A1 (en) * 1991-06-21 1992-12-22 David N. Brems Insulin analogs
CZ342492A3 (en) * 1991-11-26 1993-06-16 Lilly Co Eli Derivatives of tri-arginine insulin, process of their preparation and a pharmaceutical composition in which said derivatives are comprised
US6933272B1 (en) 1998-09-22 2005-08-23 Erik Helmerhorst Use of non-peptidyl compounds for the treatment of insulin related ailments
JP2005501530A (en) * 2001-06-08 2005-01-20 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド Nucleic acid constructs useful for glucose-regulated production of human insulin in somatic cell lines
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
US7396936B1 (en) 2004-11-09 2008-07-08 Kemia, Inc. Modulators of calcitonin and amylin receptor activity
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
WO2008043033A2 (en) 2006-10-04 2008-04-10 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
US20080260820A1 (en) * 2007-04-19 2008-10-23 Gilles Borrelly Oral dosage formulations of protease-resistant polypeptides
WO2010028175A1 (en) 2008-09-08 2010-03-11 The Board Of Trustees Of The Leland Stanford Junior University Modulators of aldehyde dehydrogenase activity and methods of use thereof
EP2349279A4 (en) 2008-10-28 2013-12-25 Univ Leland Stanford Junior Modulators of aldehyde dehydrogenase and methods of use thereof
WO2012149106A1 (en) 2011-04-29 2012-11-01 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for increasing proliferation of adult salivary stem cells
US9908925B2 (en) 2011-10-27 2018-03-06 Case Western Reserve University Ultra-concentrated rapid-acting insulin analogue formulations
EP2970124B1 (en) 2013-03-14 2019-05-22 The Board of Trustees of the Leland Stanford Junior University Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3420810A (en) * 1966-10-25 1969-01-07 Atomic Energy Commission Process for joining the a and b chains of insulin
DE2252157C3 (en) * 1972-10-25 1976-03-18 Hoechst Ag INTERMEDIATE PRODUCTS FOR THE MANUFACTURE OF INSULIN, INSULIN ANALOGS AND DERIVATIVES AND PROCESSES FOR THE MANUFACTURING OF INSULIN, INSULIN ANALOGS AND DERIVATIVES
DE2253327A1 (en) * 1972-10-31 1974-05-09 Hoechst Ag PROCESS FOR THE MANUFACTURING OF INSULIN, INSULIN ANALOGS AND DERIVATIVES
DD153829A1 (en) * 1979-08-09 1982-02-03 Guenter Losse METHOD FOR PRODUCING NOVEL HYBRIDINSULINS WITH INSULINARY EFFECT
US4421685A (en) * 1980-03-27 1983-12-20 Eli Lilly And Company Process for producing an insulin
US4430266A (en) * 1980-11-28 1984-02-07 Eli Lilly And Company Process for producing an insulin precursor
DOP1982004086A (en) * 1981-08-27 1988-03-22 Lilly Co Eli PHARMACEUTICAL FORMULA INCLUDING HUMAN INSULIN AND HUMAN PROINSULIN
US4652548A (en) * 1981-08-27 1987-03-24 Eli Lilly And Company Pharmaceutical formulations comprising human insulin, human C-peptide, and human proinsulin
US4459226A (en) * 1982-02-26 1984-07-10 Eli Lilly And Company Process for recovering insulin
DE3378250D1 (en) * 1982-04-22 1988-11-24 Ici Plc Continuous release formulations
US4581165A (en) * 1984-06-14 1986-04-08 Eli Lilly And Company Anti-diabetic compounds
US4569791A (en) * 1984-06-14 1986-02-11 Eli Lilly And Company Anti-diabetic compounds
US4569792A (en) * 1984-06-14 1986-02-11 Eli Lilly And Company Anti-diabetic compounds
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation

Also Published As

Publication number Publication date
FI900249A0 (en) 1990-01-16
JPH02504274A (en) 1990-12-06
DE3887338T2 (en) 1994-05-05
DK13990A (en) 1990-01-17
EP0382732B1 (en) 1994-01-19
EP0382732A1 (en) 1990-08-22
DK13990D0 (en) 1990-01-17
HU205145B (en) 1992-03-30
WO1989000580A1 (en) 1989-01-26
FI98731C (en) 1997-08-11
AU616131B2 (en) 1991-10-17
AU2126988A (en) 1989-02-13
US4992418A (en) 1991-02-12
KR920700227A (en) 1992-02-19
DE3887338D1 (en) 1994-03-03
HUT54178A (en) 1991-01-28
JP2729498B2 (en) 1998-03-18
KR970009353B1 (en) 1997-06-10

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Legal Events

Date Code Title Description
BB Publication of examined application
MM Patent lapsed

Owner name: MOUNT SINAI SCHOOL OF MEDICINE OF THE