FI981217A - GFRalfa2-negative mice as experimental models for certain human diseases - Google Patents

GFRalfa2-negative mice as experimental models for certain human diseases

Info

Publication number
FI981217A
FI981217A FI981217A FI981217A FI981217A FI 981217 A FI981217 A FI 981217A FI 981217 A FI981217 A FI 981217A FI 981217 A FI981217 A FI 981217A FI 981217 A FI981217 A FI 981217A
Authority
FI
Finland
Prior art keywords
gfralfa2
human diseases
experimental models
certain human
negative mice
Prior art date
Application number
FI981217A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI981217A0 (en
Inventor
Matti S Airaksinen
Mart Saarma
Original Assignee
Matti S Airaksinen
Mart Saarma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matti S Airaksinen, Mart Saarma filed Critical Matti S Airaksinen
Priority to FI981217A priority Critical patent/FI981217A/en
Publication of FI981217A0 publication Critical patent/FI981217A0/en
Priority to PCT/FI1999/000464 priority patent/WO1999062332A1/en
Priority to AU46182/99A priority patent/AU4618299A/en
Publication of FI981217A publication Critical patent/FI981217A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knockout animals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy
FI981217A 1998-05-29 1998-05-29 GFRalfa2-negative mice as experimental models for certain human diseases FI981217A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FI981217A FI981217A (en) 1998-05-29 1998-05-29 GFRalfa2-negative mice as experimental models for certain human diseases
PCT/FI1999/000464 WO1999062332A1 (en) 1998-05-29 1999-05-27 TRANSGENIC ANIMALS LACKING A FUNCTIONAL GFRα2 RECEPTOR AS WELL AS METHODS FOR THEIR PRODUCTION AND USE
AU46182/99A AU4618299A (en) 1998-05-29 1999-05-27 Transgenic animals lacking a functional gfralpha2 receptor as well as methods for their production and use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI981217A FI981217A (en) 1998-05-29 1998-05-29 GFRalfa2-negative mice as experimental models for certain human diseases

Publications (2)

Publication Number Publication Date
FI981217A0 FI981217A0 (en) 1998-05-29
FI981217A true FI981217A (en) 1999-11-30

Family

ID=8551853

Family Applications (1)

Application Number Title Priority Date Filing Date
FI981217A FI981217A (en) 1998-05-29 1998-05-29 GFRalfa2-negative mice as experimental models for certain human diseases

Country Status (3)

Country Link
AU (1) AU4618299A (en)
FI (1) FI981217A (en)
WO (1) WO1999062332A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6677135B1 (en) 1996-05-08 2004-01-13 Biogen, Inc. Ret ligand (RetL) for stimulating neutral and renal growth
FI20000394A0 (en) * 2000-02-21 2000-02-21 Airaksinen Matti Substances related to or derived from GFRa4 and their use

Also Published As

Publication number Publication date
FI981217A0 (en) 1998-05-29
AU4618299A (en) 1999-12-20
WO1999062332A1 (en) 1999-12-09

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