FI97947B - Process for making a pharmaceutical preparation - Google Patents

Description

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_ F 1000097947B

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UTLAGGNINGSSKRIPT 97947 • • ΤίΛ? v (51) Kv.lk.6 - Int.cl.6 A 61J 3/00, 3/07, A 61K 9/48, A 61M 31/00, FINLAND-FINLAND A61F 6/14 (21) Patent application - Patentansökning 944460 (22) HakemispSivS - Ansökningsdag 27.09.94 (24) AlkupSivS - Löpdag 27.09.94

National Board of Patents and Registration (4i) Has become public - Blivit offentiig 28.03.96

Patent- och registerstyrelsen (44) Date of publication and date of publication. -

Ansökan utlagd och utl.skriften pubi icerad 13.12.96 (71) Hakija - Sökande 1. Leiras Oy, PO Box 415, 20101 Turku, (FI) (72) KeksiJS - Uppfinnare 1. Aaltonen, Marko, Ketunkulmantie 197, 21380 Aura, ( FI) 2. Lehtinen, Matti. Pyhän Katariinan tie 316, 20760 Piispanristi, (H) 3. Puhakka, Olli, Li punkantajankatu 5 C 39, 20360 Turku, (FI) (74) Agent - Ombudsman: Turku Patenttitoimisto Oy (54) Title of the invention - Uppfinningens benämning

Method 1 for the preparation of a preparation For the preparation of a compound preparation (56) Reference publications - An publication publication US A 4695466 (A 61J 3/07) (57) Seals? - Sammandrag

The invention relates to a process for the preparation of a medicament comprising at least two layers, the outer layer (B) surrounding the inner active substance-containing layer (A). The material forming the outer layer is compressed. ~ through a nozzle path (10) / in which the seat (12) is provided with an axial air duct (13). It is characterized in the invention that during the extrusion of the outer layer (B), the inner layer (A) of the nozzle is fed to the die (13) in the form of an inner layer (A). prefabricated pieces (AI, r 2] Tjj— A2, A3 ...) which, after the nozzle, are brought into permanent contact with β * 3 in the form of a tubular __

with the outer layer (B). The ^ ^ _ /) SC thus obtained

'' • Ai tape (AB) is cut to the desired size μ.

into pieces (ABI, AB2, AB3...). ^ -C.1

V'T'-AI

Claims (11)

A method of preparing an implant consisting of at least two layers and containing an active substance, the implant being intended to be placed under the skin or in a body cavity, wherein an outer layer (B) surrounds an inner layer (A) containing it. active agent, wherein the layers (A) and (B) consist of a suitable polymer or polymer blend, and the material forming the outer layer is pressed through such a nozzle (10), the dose outlet (12) of which is provided with an axis-directed air channel (13). , During which the extrusion of the outer layer (B) is fed into pre-made pieces (AI, A2, A3 ...) formed in the nozzle air duct (13) which form the inner layer (A), characterized therein. that the pieces (AI, A2, A3 ...) after the nozzle are brought into permanent contact with the tubular outer layer (B), and the thus obtained band (AB) is cut into pieces (ABI, AB2, AB3 ...) by the desired size. Method according to Claim 1, characterized in that the bits (AI, A2, A3 ...) are fed at regular intervals, whereby the tubular outer layer 20 (B) coming from the nozzle has bits (AI, A2, A3 ... ) at a fixed distance (V) from each other. 3. A method according to claim 2, characterized in that the intermediate input of the bits (AI, A2, A3 ...) continues with air blowing through the duct (13), - cuts the formed band (AB) in the middle of the distance (V). between the adjacent bits (AI and (A2), - attach plugs (T) to the ends of the cut band bits (ABI, AB2, AB3 ...) to protect the bits (AI, A2, A3 ...) in it inner layer A. Method according to claim 2, characterized in that - between the input of the bits (AI, A2, A3 ...) into the channel (13), pre-manufactured bits (C1, C2, C3 ...) are fed by a component (C) which does not contain active substance, and - cuts the formed band (ABC) on the bit (C1) located between adjacent bits (AI and A2). Method according to claim 4, characterized in that bits (C1, A2, A3 ...) are placed between bits (C1, C2, C3 ...) in a row (A1-C1-A2-C2 ...) , wherein the bits of the component (A) containing the active substance and the bits of the component (C) not containing the active substance occur in turn, feeding the row (A1-C1-A2-C2 -) as a continuous band in the nozzle's air duct (13 ) during the extrusion of the outer layer (B). Method according to claim 5, characterized in that the bit rows (A1-C1-A2-C2 ...) are manufactured by cutting the extruded strips (A) and (C) into bits (AI, Cl, A2, C2 ...) of suitable size which are alternately placed one after the other to form the row (A1-C1-A2-C2 ...). Process according to any of claims 1-6, characterized in that each of the bits (AI, A2, A3 ...) containing active substance comprises two or more immediately fed bits (A ', A' ', A '' '...) containing various active substances. Method according to any of the previous claims, characterized in that the strip (AB) or (ABC) coming from the nozzle is cured to attach the components (A), (B) and (C) to each other. Method according to any of the previous claims, characterized in that as a component (B) and (C) and as a material for the plugs (T), a suitable polymer or polymer mixture is used which permeates the active substance 30 with a certain property. 10. A method according to claim 1, characterized in that a hormone is used as an active substance. 13 97947 Method according to claim 7, characterized in that two different hormones or one hormone and an anti-inflammatory substance are used as active substances. • • m • · · • • • 1 2 3 · • · · · 2 • · · »• ·» 3 »·· • · •> m i · • · ·