FI963989A - Homogeneous methods of determination based on the transmission of luminescence energy - Google Patents

Homogeneous methods of determination based on the transmission of luminescence energy Download PDF

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Publication number
FI963989A
FI963989A FI963989A FI963989A FI963989A FI 963989 A FI963989 A FI 963989A FI 963989 A FI963989 A FI 963989A FI 963989 A FI963989 A FI 963989A FI 963989 A FI963989 A FI 963989A
Authority
FI
Finland
Prior art keywords
transmission
determination based
luminescence energy
homogeneous methods
homogeneous
Prior art date
Application number
FI963989A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI963989A0 (en
Inventor
Ilkka Antero Hemmilae
Pertti Juhani Hurskainen
Kaj Runar Blomberg
Veli-Matti Mukkala
Harri Juhani Takalo
Satu Anneli Kovanen
Stuart Alan Webb
Original Assignee
Wallac Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wallac Oy filed Critical Wallac Oy
Priority to FI963989A priority Critical patent/FI963989A/en
Publication of FI963989A0 publication Critical patent/FI963989A0/en
Priority to PCT/FI1997/000560 priority patent/WO1998015830A2/en
Priority to JP10517208A priority patent/JP2001502055A/en
Priority to EP97919087A priority patent/EP0929810A2/en
Publication of FI963989A publication Critical patent/FI963989A/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57434—Specifically defined cancers of prostate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/40—Rare earth chelates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
FI963989A 1996-10-04 1996-10-04 Homogeneous methods of determination based on the transmission of luminescence energy FI963989A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FI963989A FI963989A (en) 1996-10-04 1996-10-04 Homogeneous methods of determination based on the transmission of luminescence energy
PCT/FI1997/000560 WO1998015830A2 (en) 1996-10-04 1997-09-19 Homogenous luminescence energy transfer assays
JP10517208A JP2001502055A (en) 1996-10-04 1997-09-19 Homogeneous luminescence energy transfer assay
EP97919087A EP0929810A2 (en) 1996-10-04 1997-09-19 Homogenous luminescence energy transfer assays

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI963989A FI963989A (en) 1996-10-04 1996-10-04 Homogeneous methods of determination based on the transmission of luminescence energy

Publications (2)

Publication Number Publication Date
FI963989A0 FI963989A0 (en) 1996-10-04
FI963989A true FI963989A (en) 1998-04-05

Family

ID=8546810

Family Applications (1)

Application Number Title Priority Date Filing Date
FI963989A FI963989A (en) 1996-10-04 1996-10-04 Homogeneous methods of determination based on the transmission of luminescence energy

Country Status (4)

Country Link
EP (1) EP0929810A2 (en)
JP (1) JP2001502055A (en)
FI (1) FI963989A (en)
WO (1) WO1998015830A2 (en)

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FR2792072A1 (en) * 1999-04-08 2000-10-13 Cis Bio Int HOMOGENEOUS METHOD OF DETECTING OR DETERMINING A CHEMICAL OR PHYSICOCHEMICAL INTERACTION
WO2001040805A1 (en) * 1999-11-30 2001-06-07 Akzo Nobel N.V. Steroid compounds for steroid receptor binding assays
JP2001255326A (en) * 2000-01-31 2001-09-21 Pen State Res Found:The Inquiry related to change of content in hermetically sealed container
FI20000333A0 (en) 2000-02-16 2000-02-16 Jussi Nurmi A homogeneous method for detecting a polynucleotide
US7160735B2 (en) 2000-04-28 2007-01-09 Monogram Biosciences, Inc. Tagged microparticle compositions and methods
US7771929B2 (en) 2000-04-28 2010-08-10 Monogram Biosciences, Inc. Tag library compounds, compositions, kits and methods of use
FR2809817B1 (en) * 2000-06-02 2003-08-15 Cis Bio Int METHOD FOR DETECTING THE PRESENCE OF A LIQUID IN A MIXTURE
DE10058596A1 (en) * 2000-11-25 2002-06-06 Aventis Pharma Gmbh Method of screening chemical compounds for modulating the interaction of an EVH1 domain or a protein with an EVH1 domain with an EVH1 binding domain or a protein with an EVH1 binding domain, and a method for detecting said interaction
WO2002088733A1 (en) 2001-04-23 2002-11-07 Eiken Kagaku Kabushiki Kaisha Analysis method using reporter (label) intermolecular interaction
WO2002094998A2 (en) 2001-05-21 2002-11-28 Aclara Biosciences, Inc. Analyzing phosphorylated proteins
PL373962A1 (en) 2001-05-21 2005-09-19 Aclara Biosciences, Inc. Methods and compositions for analyzing proteins
WO2002097112A2 (en) 2001-05-26 2002-12-05 Aclara Biosciences, Inc. Catalytic amplification of multiplexed assay signals
US7211440B2 (en) * 2002-03-08 2007-05-01 Wallac Oy Dissociative fluorescence enhancement assay
US20040229294A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
JP4206378B2 (en) 2002-07-08 2009-01-07 哲雄 長野 Fluorescent probe
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US7696245B2 (en) 2003-03-28 2010-04-13 Sekisui Medical Co., Ltd. Fluorescent probe for zinc
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BRPI0414987A (en) 2003-10-01 2006-11-21 Wallac Oy homogeneous improved time-resolved energy transfer test
WO2005062048A1 (en) 2003-12-01 2005-07-07 Dade Behring Marburg Gmbh Homogeneous detection method
JP2005194244A (en) 2004-01-09 2005-07-21 Shigenobu Yano Zinc ion fluorescence sensor
GB2433993B (en) * 2004-10-19 2010-04-28 Wallac Oy Single molecule TR-FRET probe
US20060115842A1 (en) * 2004-10-22 2006-06-01 Wallac Oy Highly sensitive homogeneous assay based on anti-Stokes' shift FRET measurement
JP4683572B2 (en) * 2005-01-28 2011-05-18 塩野義製薬株式会社 Quantification of recombinant protein
US7826052B2 (en) 2005-05-24 2010-11-02 Hidex Oy Correction method and measurement device for anti-stokes photoluminescence measurement
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JPWO2007125822A1 (en) * 2006-04-28 2009-09-10 国立大学法人東京工業大学 Complex for drug screening
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EP2348128A1 (en) 2010-01-21 2011-07-27 Sanofi Methods and uses relating to the identification of compound involved in pain as well as methods of diagnosing algesia
EP2547788A1 (en) 2010-03-18 2013-01-23 Sanofi Methods and uses relating to the identification of compound involved in pain as well as methods of diagnosing algesia
US20130079239A1 (en) 2010-03-18 2013-03-28 Sanofi Methods and uses relating to the identification of compound involved in pain as well as methods of diagnosing algesia
JP2013521792A (en) 2010-03-18 2013-06-13 サノフイ Methods and uses relating to identifying compounds related to pain and methods for diagnosing hyperalgesia
EP2390349A1 (en) 2010-05-25 2011-11-30 Sanofi Methods and uses relating to the identification of compound involved in pain as well as methods of diagnosing algesia
EP2390348A1 (en) 2010-05-25 2011-11-30 Sanofi Methods and uses relating to the identification of compound involved in pain as well as methods of diagnosing algesia
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Also Published As

Publication number Publication date
FI963989A0 (en) 1996-10-04
EP0929810A2 (en) 1999-07-21
JP2001502055A (en) 2001-02-13
WO1998015830A3 (en) 1998-06-18
WO1998015830A2 (en) 1998-04-16

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