FI962841A - Macroencapsulated secretory cells - Google Patents

Macroencapsulated secretory cells Download PDF

Info

Publication number
FI962841A
FI962841A FI962841A FI962841A FI962841A FI 962841 A FI962841 A FI 962841A FI 962841 A FI962841 A FI 962841A FI 962841 A FI962841 A FI 962841A FI 962841 A FI962841 A FI 962841A
Authority
FI
Finland
Prior art keywords
secretory cells
agarose
macroencapsulated
macroencapsulated secretory
coated
Prior art date
Application number
FI962841A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI118853B (en
FI962841A0 (en
Inventor
Kanti Jain
Albert L Rubin
Original Assignee
Rogosin Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rogosin Inst filed Critical Rogosin Inst
Publication of FI962841A0 publication Critical patent/FI962841A0/en
Publication of FI962841A publication Critical patent/FI962841A/en
Application granted granted Critical
Publication of FI118853B publication Critical patent/FI118853B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/76—Agarose, agar-agar

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physiology (AREA)
  • Dispersion Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention involves an agarose coated, agarose secretory cell macrobead, and an agarose coated, agarose-collagen secretory cell macrobead
FI962841A 1994-01-13 1996-07-12 Macroencapsulated secretory cells FI118853B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US18126994A 1994-01-13 1994-01-13
US18126994 1994-01-13
US9500400 1995-01-12
PCT/US1995/000400 WO1995019430A1 (en) 1994-01-13 1995-01-12 Macroencapsulated secretory cells

Publications (3)

Publication Number Publication Date
FI962841A0 FI962841A0 (en) 1996-07-12
FI962841A true FI962841A (en) 1996-09-12
FI118853B FI118853B (en) 2008-04-15

Family

ID=22663563

Family Applications (1)

Application Number Title Priority Date Filing Date
FI962841A FI118853B (en) 1994-01-13 1996-07-12 Macroencapsulated secretory cells

Country Status (19)

Country Link
US (3) US5643569A (en)
EP (3) EP1666585B1 (en)
JP (4) JP3948742B2 (en)
KR (1) KR100474803B1 (en)
CN (1) CN1087779C (en)
AT (3) ATE320482T1 (en)
AU (1) AU681240C (en)
CA (1) CA2181156C (en)
DE (3) DE69534865T2 (en)
DK (2) DK1666585T3 (en)
ES (3) ES2260568T3 (en)
FI (1) FI118853B (en)
HK (1) HK1084693A1 (en)
IL (1) IL112330A (en)
NO (2) NO323228B1 (en)
NZ (3) NZ509363A (en)
PT (3) PT1666585E (en)
RU (2) RU2177503C2 (en)
WO (1) WO1995019430A1 (en)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830492A (en) * 1992-02-24 1998-11-03 Encelle, Inc. Bioartificial devices and cellular matrices therefor
US6231881B1 (en) 1992-02-24 2001-05-15 Anton-Lewis Usala Medium and matrix for long-term proliferation of cells
US5824331A (en) * 1992-02-24 1998-10-20 Encelle, Inc. Bioartificial devices and cellular matrices therefor
US5834005A (en) * 1992-02-24 1998-11-10 Encelle, Inc. Bioartificial devices and cellular matrices therefor
USRE39542E1 (en) * 1994-01-13 2007-04-03 The Rogosin Institute Preparation of agarose coated, solid agarose-collagen beads containing secretory cells
WO1995019430A1 (en) * 1994-01-13 1995-07-20 The Rogosin Institute Macroencapsulated secretory cells
US5916790A (en) * 1995-03-03 1999-06-29 Metabolex, Inc. Encapsulation compositions, and methods
AU705108B2 (en) * 1995-03-03 1999-05-13 Metabolex, Inc. Novel encapsulation process by a gelling polymer
US5965125A (en) * 1995-10-25 1999-10-12 Transkaryotic Therapies, Inc. Hybrid matrix implants and explants
US6419920B1 (en) 1995-10-25 2002-07-16 Trans Karyotic Therapies, Inc. Hybrid matrix implants and explants
JPH11508477A (en) * 1996-02-23 1999-07-27 サーシ・バイオメディカル・インコーポレーテッド New artificial pancreas
US6303151B1 (en) * 1996-04-03 2001-10-16 The Rogosin Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
KR100477296B1 (en) * 1996-04-03 2005-05-16 더 로고신 인스티튜트 Implantable Agarose-Collagen Beads Containing Cells Which Produce a Diffusible Biological Product, and Uses Thereof
US6224912B1 (en) * 1996-04-03 2001-05-01 The Rogo Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
US7297331B2 (en) 1996-04-03 2007-11-20 The Rogosin Institute Beads containing restricted cancer cells producing material suppressing cancer cell proliferation
ATE374034T1 (en) * 1996-04-03 2007-10-15 Rogosin Inst CONDITIONED MEDIUM AND DIFFUSIVE BIOLOGICAL MATERIAL OBTAINED BY INCUBATION OF ENCAPLED CELLS
US5888497A (en) * 1996-04-03 1999-03-30 The Rogosin Institute Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation
NZ334721A (en) 1996-09-13 2001-01-26 Transkaryotic Therapies Inc Purified human alpha-galactosidase A and therapeutic use
US6368858B1 (en) 1997-07-22 2002-04-09 The General Hospital Corporation Modulation of multicellular aggregates by pressure from growth in a matrix
US5922339A (en) * 1998-01-27 1999-07-13 Usala; Anton-Lewis Compositions and methods for biocompatible implants
US6303355B1 (en) 1999-03-22 2001-10-16 Duke University Method of culturing, cryopreserving and encapsulating pancreatic islet cells
US6365385B1 (en) 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
US6391576B1 (en) * 1999-10-13 2002-05-21 Japan Bioindustry Association Method for isolating a microbe
US6279656B1 (en) 1999-11-03 2001-08-28 Santrol, Inc. Downhole chemical delivery system for oil and gas wells
NZ523461A (en) 2000-05-31 2004-11-26 Encelle Inc Method of treating chronic ulcers
US20040191246A1 (en) 2003-02-26 2004-09-30 Connelly Patrick R. Process for in vivo treatment of specific biological targets in bodily fluid
WO2004058305A2 (en) * 2002-12-24 2004-07-15 An-Go-Gen Inc. Encapsulated cell for therapy
US20050053586A1 (en) 2003-09-04 2005-03-10 Bryan Conn Entrapped stem cells and uses thereof
US20060121077A1 (en) * 2004-11-11 2006-06-08 Lawrence Gazda Method for treating patients with implants of islets which have been kept in long term, in vitro culture
CA2622529C (en) * 2005-09-26 2014-02-18 Lawrence Gazda Secretory cell-containing macrobeads comprising seakem gold agarose, and uses thereof
US20070116680A1 (en) * 2005-11-18 2007-05-24 Rensselaer Polytechnic Institute Stem cells within gel microenvironments
ES2386123T3 (en) 2006-06-16 2012-08-09 Fmc Biopolymer As Cellular device with an alginate-coated collagen matrix, process for its formation and uses
WO2008090501A1 (en) * 2007-01-24 2008-07-31 Koninklijke Philips Electronics N. V. Process for treating cultured cells
KR20100049084A (en) 2007-08-23 2010-05-11 인트렉손 코포레이션 Methods and compositions for diagnosing disease
CA2715080C (en) * 2007-09-28 2021-09-28 Intrexon Corporation Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof
DE102010040687A1 (en) 2010-09-14 2012-03-15 Hamilton Bonaduz Ag Process for producing active agent beads
WO2012127224A1 (en) 2011-03-21 2012-09-27 University Of Reading Transport of cells in hydrogels
DE102011050024A1 (en) 2011-04-29 2012-10-31 Hamilton Bonaduz Ag Analytical device for a non-contact analysis of the formation of a transparent body and method for carrying out the non-contact analysis
PL2809782T3 (en) * 2012-01-31 2018-04-30 The Rogosin Institute, Inc. Improved method for manufacture of macrobeads
KR101327630B1 (en) * 2012-03-05 2013-11-13 울산대학교 산학협력단 Method for manufacturing a carrier of transplanting pancreatic islet cells using atelocollagen, and artificial pancreas manufactured by the same method
UY38389A (en) 2018-09-27 2020-04-30 Sigilon Therapeutics Inc IMPLANTABLE DEVICES FOR CELLULAR THERAPY AND RELATED METHODS
WO2024081309A1 (en) 2022-10-11 2024-04-18 Sigilon Therapeutics, Inc. Engineered cells and implantable elements for treatment of disease
WO2024081310A1 (en) 2022-10-11 2024-04-18 Sigilon Therapeutics, Inc. Engineered cells and implantable elements for treatment of disease

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4391909A (en) * 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
US4409331A (en) * 1979-03-28 1983-10-11 Damon Corporation Preparation of substances with encapsulated cells
US4352883A (en) * 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
SE441009B (en) * 1982-03-08 1985-09-02 Kjell Nilsson WAY TO IMMOBILIZE LIVING BIOMATERIAL IN PEARLY POLYMERS
US4798786A (en) * 1982-05-06 1989-01-17 Stolle Research And Development Corporation Living cells encapsulated in crosslinked protein
CA1196862A (en) * 1983-06-01 1985-11-19 Anthony M.F. Sun Microencapsulation of living tissue and cells
US4663286A (en) * 1984-02-13 1987-05-05 Damon Biotech, Inc. Encapsulation of materials
US4902295A (en) * 1985-08-26 1990-02-20 Hana Biologics, Inc. Transplantable artificial tissue
US4997443A (en) * 1985-08-26 1991-03-05 Hana Biologics, Inc. Transplantable artificial tissue and process
SE8604684L (en) * 1986-11-03 1988-05-04 Excorim Kommanditbolag SET TO COAT SOLID PARTICLES WITH A HYDROPHIL GEL AND THROUGH SEAT COATED PARTICLES
US5053332A (en) * 1989-07-24 1991-10-01 Cook Richard B Agarose beads, preferably incorporating biological materials
US5227298A (en) * 1990-08-17 1993-07-13 The Trustees Of Columbia University In The City Of New York Method for microencapuslation of cells or tissue
FR2686250A1 (en) * 1992-01-16 1993-07-23 Coletica INJECTABLE COMPOSITIONS CONTAINING SUSPENSION OF COLLAGEN - BASED MICROCAPSULES, THEIR BIOMEDICAL USE AND PHARMACEUTICAL COMPOSITIONS.
EP0641183B1 (en) * 1992-05-29 2001-10-31 The Regents Of The University Of California Coated transplant and method for making same
WO1994012161A1 (en) * 1992-11-24 1994-06-09 Clover Consolidated, Limited Cytoprotective, biocompatible, retrievable macrocapsules
WO1995019430A1 (en) * 1994-01-13 1995-07-20 The Rogosin Institute Macroencapsulated secretory cells
US5888497A (en) * 1996-04-03 1999-03-30 The Rogosin Institute Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation
US6224912B1 (en) * 1996-04-03 2001-05-01 The Rogo Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment

Also Published As

Publication number Publication date
JP2005137376A (en) 2005-06-02
JPH09510868A (en) 1997-11-04
EP0742818B1 (en) 2004-09-01
ATE408005T1 (en) 2008-09-15
CN1087779C (en) 2002-07-17
CA2181156A1 (en) 1995-07-20
ES2227544T3 (en) 2005-04-01
KR100474803B1 (en) 2005-03-10
RU2177503C2 (en) 2001-12-27
NO324570B1 (en) 2007-11-26
KR20050005235A (en) 2005-01-13
DE69534865D1 (en) 2006-05-11
AU681240B2 (en) 1997-08-21
NO323228B1 (en) 2007-02-05
EP0742818A4 (en) 2002-01-09
ATE320482T1 (en) 2006-04-15
US5643569A (en) 1997-07-01
AU1526795A (en) 1995-08-01
FI118853B (en) 2008-04-15
DE69533437D1 (en) 2004-10-07
JP2007020585A (en) 2007-02-01
JP3948742B2 (en) 2007-07-25
DE69533437T2 (en) 2005-09-15
JP2006345875A (en) 2006-12-28
EP1666585B1 (en) 2008-09-10
ES2309849T3 (en) 2008-12-16
WO1995019430A1 (en) 1995-07-20
CN1141650A (en) 1997-01-29
NZ329619A (en) 1999-09-29
PT1666585E (en) 2008-12-10
DE69534865T2 (en) 2006-08-17
EP1418228A1 (en) 2004-05-12
FI962841A0 (en) 1996-07-12
USRE40555E1 (en) 2008-10-28
NO20051359L (en) 1996-09-11
NO962955D0 (en) 1996-07-15
CA2181156C (en) 2001-10-16
JP4435134B2 (en) 2010-03-17
HK1084693A1 (en) 2006-08-04
NZ509363A (en) 2006-02-24
EP1666585A1 (en) 2006-06-07
AU681240C (en) 2006-12-07
PT1418228E (en) 2006-09-29
ES2260568T3 (en) 2006-11-01
USRE38027E1 (en) 2003-03-11
NZ278809A (en) 1998-03-25
EP0742818A1 (en) 1996-11-20
IL112330A (en) 1999-01-26
MX9602765A (en) 1998-06-30
IL112330A0 (en) 1995-03-30
EP1418228B1 (en) 2006-03-15
DK1666585T3 (en) 2009-01-12
RU2208636C2 (en) 2003-07-20
NO962955L (en) 1996-09-11
PT742818E (en) 2004-12-31
ATE275194T1 (en) 2004-09-15
DE69535842D1 (en) 2008-10-23
DK1418228T3 (en) 2006-07-17
JP3989492B2 (en) 2007-10-10

Similar Documents

Publication Publication Date Title
FI962841A (en) Macroencapsulated secretory cells
NO995180L (en) Power control in radio networks, especially of the CDMA category
FI960631A0 (en) Thermostable xylanases
EE9900308A (en) Methods and systems for the operation of cellular mobile terminals with limited power
DE69525441D1 (en) Power Factor Correction
DE69522335D1 (en) Class BC power amplifier for AM-FM transmitters
NO910312D0 (en) PROCEDURE FOR THE MANUFACTURE OF ELECTRODES FOR ELECTROCHEMICAL CELLS.
NO861174L (en) FOREIGN PLATFORM AND PROCEDURE FOR INSTALLING THE SAME.
BR9607041A (en) Primary electrochemical cell
DK0954903T3 (en) Method of regulating the power gain
DE59510269D1 (en) Power semiconductor component
ES1032443Y (en) OVEN.
NO912123L (en) POWER SUPPLIER FOR AN ELECTRODE.
DE69514758D1 (en) Load cells
KR960025010U (en) Through-condenser structure for suppressing leakage at the power stage
KR960008703U (en) Microwave power regulator
KR960025430U (en) Wafer chuck device with stage tilt compensation
FI945329A0 (en) Testing Foer en basstation i en utvidgad cell
DK403283A (en) PROCEDURE FOR INSTALLING THE BEARING / CRUMP GROUP IN HERMETIC COMPRESSORS
KR960005887U (en) Electrical primer
KR960002458U (en) Electric stove for humidifier
KR950031467U (en) Ion implantation regulator
NO961415D0 (en) Electrolyte Amplifier
KR960002455U (en) Microwave power regulator
KR950034649U (en) Power Off Circuit Using Voice Level

Legal Events

Date Code Title Description
FG Patent granted

Ref document number: 118853

Country of ref document: FI

MA Patent expired