FI955605A0 - Aryling drug - Google Patents
Aryling drugInfo
- Publication number
- FI955605A0 FI955605A0 FI955605A FI955605A FI955605A0 FI 955605 A0 FI955605 A0 FI 955605A0 FI 955605 A FI955605 A FI 955605A FI 955605 A FI955605 A FI 955605A FI 955605 A0 FI955605 A0 FI 955605A0
- Authority
- FI
- Finland
- Prior art keywords
- aryling
- drug
- aryling drug
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/04—Nitro compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
- A61K31/06—Phenols the aromatic ring being substituted by nitro groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/06—Compounds containing nitro groups bound to a carbon skeleton having nitro groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
- C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
- C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
- C07C205/20—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings
- C07C205/21—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C205/24—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring having three, and only three, nitro groups bound to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
- C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/58—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
- C07C211/52—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/39—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing halogen atoms bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/40—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitro or nitroso groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
- C07C309/46—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/68—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings containing halogen
- C07C63/70—Monocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939310520A GB9310520D0 (en) | 1993-05-21 | 1993-05-21 | Arylating agents |
GB9405292A GB9405292D0 (en) | 1993-05-21 | 1994-03-17 | Arylating agents |
PCT/GB1994/001126 WO1994027584A2 (en) | 1993-05-21 | 1994-05-23 | Arylating medicaments |
Publications (2)
Publication Number | Publication Date |
---|---|
FI955605A0 true FI955605A0 (en) | 1995-11-21 |
FI955605A FI955605A (en) | 1996-01-22 |
Family
ID=26302926
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI955605A FI955605A (en) | 1993-05-21 | 1995-11-21 | Arylating drugs |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0700287A1 (en) |
JP (1) | JPH08510468A (en) |
CN (1) | CN1124012A (en) |
AP (1) | AP9400647A0 (en) |
AU (1) | AU6729794A (en) |
BG (1) | BG100242A (en) |
BR (1) | BR9406548A (en) |
CA (1) | CA2163459A1 (en) |
CZ (1) | CZ307395A3 (en) |
DZ (1) | DZ1781A1 (en) |
FI (1) | FI955605A (en) |
HU (1) | HUT77764A (en) |
IL (1) | IL109712A0 (en) |
MA (1) | MA23202A1 (en) |
NO (1) | NO954702L (en) |
OA (1) | OA10196A (en) |
SK (1) | SK145795A3 (en) |
WO (1) | WO1994027584A2 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2288333A (en) * | 1994-03-17 | 1995-10-18 | Radopath Ltd | Benzoic acid containing chloro and or nitro groups for cancer or viral therapy |
ATE198273T1 (en) * | 1994-03-17 | 2001-01-15 | Radopath Pharmaceuticals Inter | ACTIVE SUBSTANCE AGAINST VIRUSES AND CANCER |
WO1996029067A1 (en) * | 1995-03-17 | 1996-09-26 | Radopath Limited | Anti-viral and anti-cancer agents |
WO1996030003A1 (en) * | 1995-03-30 | 1996-10-03 | Werner Kreutz | Medicaments for the selective treatment of tumour tissues |
US5756548A (en) * | 1995-04-03 | 1998-05-26 | Centaur Pharmaceuticals, Inc. | Acetamidobenzamide compounds for neurodegenerative disorders |
GB9615619D0 (en) * | 1996-03-18 | 1996-09-04 | Radopath Ltd | Costimulation of TcR/CD3-induced T-Lymphocytes |
US5955506A (en) * | 1996-04-03 | 1999-09-21 | Centaur Pharmaceuticals, Inc. | Benzamides for neurodegenerative disorder treatment |
SG164368A1 (en) * | 2005-07-18 | 2010-09-29 | Bipar Sciences Inc | Treatment of cancer |
CA2662517A1 (en) | 2006-09-05 | 2008-03-13 | Jerome Moore | Treatment of cancer |
EP2217227B1 (en) | 2007-11-12 | 2013-08-21 | BiPar Sciences, Inc. | Treatment of breast cancer with 4-iodo-3-nitrobenzamide in combination with anti-tumor agents |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1283331A (en) * | 1970-01-03 | 1972-07-26 | Smith Kline French Lab | Pharmaceutical compositions |
US3978119A (en) * | 1975-07-11 | 1976-08-31 | Gulf Research & Development Company | Process for converting stilbene or bibenzyl to nitrobenzoic acids |
US4283421A (en) * | 1979-12-19 | 1981-08-11 | Ray Frank F | Anti-viral treatment |
US4277492A (en) * | 1980-05-21 | 1981-07-07 | The Dow Chemical Company | Novel 4-bis((Phenylmethyl)amino)-benzenesulfonic acids possessing antiviral activity |
US4762705A (en) * | 1981-11-10 | 1988-08-09 | Adolf W. Schwimmer | Cancer therapy with interferon |
US4935450A (en) * | 1982-09-17 | 1990-06-19 | Therapeutical Systems Corporation | Cancer therapy system for effecting oncolysis of malignant neoplasms |
CA1262864A (en) * | 1982-09-17 | 1989-11-14 | Clarence D. Cone | Method for producing oncolysis |
JPS60224619A (en) * | 1984-04-24 | 1985-11-09 | Adeka Argus Chem Co Ltd | Radiation sensitizer |
RO92333B1 (en) * | 1985-06-18 | 1987-09-01 | Institutul De Cercetari Chimico-Farmaceutice | Tumoral cell radiosensitizing product |
JPS6468315A (en) * | 1987-09-09 | 1989-03-14 | Yasuo Kawasaki | Antipyrotic of picric acid (2,4,6-trinitrophenol) |
EP0514451B1 (en) * | 1990-02-05 | 1997-01-15 | LifeScience Corporation | Dietary supplements comprising vitamins and minerals |
CA2036695A1 (en) * | 1990-03-01 | 1991-09-02 | Brian Gregory Chapman | Solid imaging apparatus and method with coating station |
HUT62785A (en) * | 1990-04-03 | 1993-06-28 | Radopath Ltd | Process for producing pharmaceutical compositions comprising trinitrobenzenes and carminic acid, suitable for treating cancer and viral diseases |
GB9103075D0 (en) * | 1991-02-13 | 1991-03-27 | Washington Odur Ayuko | Trinitrobenzene derivatives and their therapeutic use |
US5422277A (en) * | 1992-03-27 | 1995-06-06 | Ortho Diagnostic Systems Inc. | Cell fixative composition and method of staining cells without destroying the cell surface |
-
1994
- 1994-05-18 DZ DZ940047A patent/DZ1781A1/en active
- 1994-05-20 AP APAP/P/1994/000647A patent/AP9400647A0/en unknown
- 1994-05-20 MA MA23512A patent/MA23202A1/en unknown
- 1994-05-22 IL IL10971294A patent/IL109712A0/en unknown
- 1994-05-23 CZ CZ953073A patent/CZ307395A3/en unknown
- 1994-05-23 CN CN94192181A patent/CN1124012A/en active Pending
- 1994-05-23 BR BR9406548A patent/BR9406548A/en not_active Application Discontinuation
- 1994-05-23 JP JP7500384A patent/JPH08510468A/en active Pending
- 1994-05-23 SK SK1457-95A patent/SK145795A3/en unknown
- 1994-05-23 WO PCT/GB1994/001126 patent/WO1994027584A2/en not_active Application Discontinuation
- 1994-05-23 CA CA002163459A patent/CA2163459A1/en not_active Abandoned
- 1994-05-23 HU HU9503327A patent/HUT77764A/en unknown
- 1994-05-23 EP EP94915671A patent/EP0700287A1/en not_active Ceased
- 1994-05-23 AU AU67297/94A patent/AU6729794A/en not_active Abandoned
-
1995
- 1995-11-21 FI FI955605A patent/FI955605A/en not_active Application Discontinuation
- 1995-11-21 OA OA60743A patent/OA10196A/en unknown
- 1995-11-21 NO NO954702A patent/NO954702L/en unknown
- 1995-12-21 BG BG100242A patent/BG100242A/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN1124012A (en) | 1996-06-05 |
AU6729794A (en) | 1994-12-20 |
WO1994027584A2 (en) | 1994-12-08 |
CA2163459A1 (en) | 1994-12-08 |
HU9503327D0 (en) | 1996-01-29 |
HUT77764A (en) | 1998-08-28 |
NO954702D0 (en) | 1995-11-21 |
NO954702L (en) | 1996-01-22 |
IL109712A0 (en) | 1994-08-26 |
CZ307395A3 (en) | 1996-06-12 |
EP0700287A1 (en) | 1996-03-13 |
BG100242A (en) | 1996-07-31 |
AP9400647A0 (en) | 1995-11-20 |
JPH08510468A (en) | 1996-11-05 |
WO1994027584A3 (en) | 1995-05-26 |
SK145795A3 (en) | 1996-10-02 |
OA10196A (en) | 1996-12-18 |
BR9406548A (en) | 1996-01-02 |
DZ1781A1 (en) | 2002-02-17 |
FI955605A (en) | 1996-01-22 |
MA23202A1 (en) | 1994-12-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application lapsed |