FI955386A - 4-p-fluorobenzoyl-1-piperidinyl-propoxy-chromene-4-one derivatives, their preparation and their use in the management of psychosis and schizophrenia - Google Patents

4-p-fluorobenzoyl-1-piperidinyl-propoxy-chromene-4-one derivatives, their preparation and their use in the management of psychosis and schizophrenia Download PDF

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Publication number
FI955386A
FI955386A FI955386A FI955386A FI955386A FI 955386 A FI955386 A FI 955386A FI 955386 A FI955386 A FI 955386A FI 955386 A FI955386 A FI 955386A FI 955386 A FI955386 A FI 955386A
Authority
FI
Finland
Prior art keywords
pct
psychosis
schizophrenia
chromene
fluorobenzoyl
Prior art date
Application number
FI955386A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI955386A0 (en
Inventor
Rafael Foguet
Jordi Bolos
Aurelio Sacristan
Jose A Ortiz
Original Assignee
Ferrer Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ES09400581A external-priority patent/ES2101620B1/en
Application filed by Ferrer Int filed Critical Ferrer Int
Publication of FI955386A publication Critical patent/FI955386A/en
Publication of FI955386A0 publication Critical patent/FI955386A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Abstract

PCT No. PCT/EP95/01008 Sec. 371 Date Dec. 12, 1995 Sec. 102(e) Date Dec. 12, 1995 PCT Filed Mar. 17, 1995 PCT Pub. No. WO95/25733 PCT Pub. Date Sep. 28, 1995The present invention relates to new chromene compounds of the general formula (I): <IMAGE>om 1 to 4 carbon atoms, halogen, trifluoromethyl, optionally substituted phenyl, or hydroxymethyl, as well as their pharmaceutically acceptable addition salts. These compounds are useful in the treatment of psychosis and schizophrenia.
FI955386A 1994-03-18 1995-11-08 4-p-Fluorobenzoyl-1-piperidinyl-propoxy-chromen-4-one derivatives, their preparation and use in the treatment of psychosis and schizophrenia FI955386A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ES09400581A ES2101620B1 (en) 1994-03-18 1994-03-18 NEW COMPOUND DERIVED FROM CHROMENE.
ES09401437A ES2101635B1 (en) 1994-03-18 1994-07-01 NEW CHROME-DERIVED COMPOUND
ES09500163A ES2101644B1 (en) 1994-03-18 1995-01-30 NEW CHROME-DERIVED COMPOUND
PCT/EP1995/001008 WO1995025733A1 (en) 1994-03-18 1995-03-17 4-p-fluorobenzoyl-1-piperidinyl-propoxy-chromen-4-one derivatives, their preparation and their use in the treatment of psychosis and schizophrenia

Publications (2)

Publication Number Publication Date
FI955386A true FI955386A (en) 1995-11-08
FI955386A0 FI955386A0 (en) 1995-11-08

Family

ID=27240511

Family Applications (1)

Application Number Title Priority Date Filing Date
FI955386A FI955386A0 (en) 1994-03-18 1995-11-08 4-p-Fluorobenzoyl-1-piperidinyl-propoxy-chromen-4-one derivatives, their preparation and use in the treatment of psychosis and schizophrenia

Country Status (16)

Country Link
US (1) US5643927A (en)
EP (1) EP0699197B1 (en)
JP (1) JP3170287B2 (en)
AT (1) ATE193705T1 (en)
AU (1) AU683549B2 (en)
CA (1) CA2163251A1 (en)
DE (1) DE69517371T2 (en)
DK (1) DK0699197T3 (en)
FI (1) FI955386A0 (en)
GR (1) GR3034226T3 (en)
IL (1) IL112764A0 (en)
NO (1) NO308001B1 (en)
NZ (1) NZ282810A (en)
PH (1) PH31442A (en)
PT (1) PT699197E (en)
WO (1) WO1995025733A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL117646A (en) * 1995-04-12 2000-06-01 Ferrer Int 7-¬3-¬4-(6-fluoro-1,2-benzisoxazole-3-YL)piperidin-1-YL¾propoxy¾3-alkyl-chromen-4-ones their preparation their uses and pharmaceutical compositions comprising them
ES2144355B1 (en) * 1997-12-30 2001-01-01 Ferrer Int COMPOUNDS DERIVED FROM THE CHROME.
ES2154176B1 (en) 1998-09-21 2001-10-16 Ferrer Int NEW PROCEDURE FOR OBTAINING 3- (HYDROXIMETHYL) CROMEN-4-ONAS.
US6713479B2 (en) 2001-03-02 2004-03-30 Sepracor Inc. Piperidine-piperazine ligands for neurotransmitter receptors
JP5080716B2 (en) 2001-07-20 2012-11-21 サイコジェニックス・インコーポレーテッド Treatment of attention deficit / hyperactivity disorder
US8017649B2 (en) 2005-03-11 2011-09-13 Howard Florey Institute Of Experimental Physiology And Medicine Flavonoid compounds and uses thereof
EP1829873A1 (en) * 2006-03-02 2007-09-05 Laboratorios Del Dr. Esteve, S.A. Pyrrazole derivatives as sigma receptors antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3576810A (en) * 1968-06-20 1971-04-27 Robins Co Inc A H 1-substituted-3-(-4)-aroylpiperidines
DE3117389A1 (en) * 1981-05-02 1982-11-18 Boehringer Mannheim Gmbh, 6800 Mannheim BENZOPYRANYLETHER, METHOD FOR PRODUCING THE SAME AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US4678787A (en) * 1985-01-30 1987-07-07 Warner-Lambert Company 4H-1-benzopyran-4-ones and their sulfur containing analogs
DK623586A (en) * 1985-12-27 1987-06-28 Eisai Co Ltd PIPERIDE INGREDIENTS OR SALTS THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE COMPOUNDS
JPH04502322A (en) * 1988-12-21 1992-04-23 ジ・アップジョン・カンパニー Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazin-4-ones
US5278174A (en) * 1990-06-04 1994-01-11 Scios Nova, Inc. Sigma binding site agents
EP0558245A1 (en) * 1992-02-25 1993-09-01 RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY Heterobicyclic compounds as antagogists of alpha-1 adrenergic and SHT1A receptors

Also Published As

Publication number Publication date
WO1995025733A1 (en) 1995-09-28
ATE193705T1 (en) 2000-06-15
DE69517371D1 (en) 2000-07-13
US5643927A (en) 1997-07-01
DK0699197T3 (en) 2000-08-07
FI955386A0 (en) 1995-11-08
CA2163251A1 (en) 1995-09-28
PH31442A (en) 1998-11-03
AU683549B2 (en) 1997-11-13
IL112764A0 (en) 1995-05-26
EP0699197B1 (en) 2000-06-07
JP3170287B2 (en) 2001-05-28
NO954633L (en) 1995-11-16
NZ282810A (en) 1996-11-26
AU2072095A (en) 1995-10-09
NO308001B1 (en) 2000-07-03
PT699197E (en) 2000-10-31
NO954633D0 (en) 1995-11-16
GR3034226T3 (en) 2000-12-29
DE69517371T2 (en) 2001-02-22
EP0699197A1 (en) 1996-03-06
JPH08510478A (en) 1996-11-05

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