FI953708A - Process for the preparation of therapeutically active macrocyclic bifunctional chelating agents, their complexes and their antibody conjugates - Google Patents

Process for the preparation of therapeutically active macrocyclic bifunctional chelating agents, their complexes and their antibody conjugates Download PDF

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Publication number
FI953708A
FI953708A FI953708A FI953708A FI953708A FI 953708 A FI953708 A FI 953708A FI 953708 A FI953708 A FI 953708A FI 953708 A FI953708 A FI 953708A FI 953708 A FI953708 A FI 953708A
Authority
FI
Finland
Prior art keywords
preparation
complexes
bifunctional chelating
chelating agents
therapeutically active
Prior art date
Application number
FI953708A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI953708A0 (en
FI104898B (en
Inventor
Roberta C Cheng
William A Fordyce
William F Goeckeler
Jr William J Kruper
Sharon Baughman
Joseph R Garlich
Garry E Kiefer
Kenneth Mcmillan
Jaime Simon
David A Wilson
Richard Keith Frank
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1989/002788 external-priority patent/WO1989012631A1/en
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of FI953708A publication Critical patent/FI953708A/en
Publication of FI953708A0 publication Critical patent/FI953708A0/en
Application granted granted Critical
Publication of FI104898B publication Critical patent/FI104898B/en

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention relates to a process for the preparation of macrocyclic bifunctional chelating compounds of the formula (IA) <IMAGE> wherein Q is H or (CHR5)PCO2R, Q1 is H or CO2R, R is H or C1-4 alkyl, R5 is H or C1-4 alkyl, n is an integer number between 0 and 5, p is 1 or 2, R2 and R4 are hydrogen, nitro, amino, isothiocyanato, semicarbazido, thiosemicarbazido, maleimido, bromoacetamido or carboxyl, R3 is C1-4 alkoxy, -OCH2CO2H, OH or H, and the pharmaceutically acceptable salts thereof, for the preparation of complexes of the said compounds with rare earth metal type ions and for the preparation of conjugates of said compounds or a metal complex thereof and an antibody or an antibody fragment. Products according to the invention can be used as therapeutic agents. <IMAGE>
FI953708A 1988-06-24 1995-08-03 Process for the preparation of a therapeutically active metal complex compound FI104898B (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US21149688A 1988-06-24 1988-06-24
US21149688 1988-06-24
US37095689A 1989-06-21 1989-06-21
US37095689 1989-06-21
PCT/US1989/002788 WO1989012631A1 (en) 1988-06-24 1989-06-23 Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates
US8902788 1989-06-23
FI906368A FI103792B (en) 1988-06-24 1990-12-21 Macrocyclic bifunctional chelating agents, their metal complexes and antibody conjugates of these complexes
FI906368 1990-12-21

Publications (3)

Publication Number Publication Date
FI953708A true FI953708A (en) 1995-08-03
FI953708A0 FI953708A0 (en) 1995-08-03
FI104898B FI104898B (en) 2000-04-28

Family

ID=27241442

Family Applications (1)

Application Number Title Priority Date Filing Date
FI953708A FI104898B (en) 1988-06-24 1995-08-03 Process for the preparation of a therapeutically active metal complex compound

Country Status (1)

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FI (1) FI104898B (en)

Also Published As

Publication number Publication date
FI953708A0 (en) 1995-08-03
FI104898B (en) 2000-04-28

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