FI946136A - Substituted benzenesulfonylureas and thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds - Google Patents

Substituted benzenesulfonylureas and thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds Download PDF

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Publication number
FI946136A
FI946136A FI946136A FI946136A FI946136A FI 946136 A FI946136 A FI 946136A FI 946136 A FI946136 A FI 946136A FI 946136 A FI946136 A FI 946136A FI 946136 A FI946136 A FI 946136A
Authority
FI
Finland
Prior art keywords
alk
cyclo
thioureas
compounds
processes
Prior art date
Application number
FI946136A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI107917B (en
FI946136A0 (en
Inventor
Heinrich Englert
Dieter Mania
Jens Hartung
Heinz Goegelein
Joachim Kaiser
Uwe Gerlach
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI946136A0 publication Critical patent/FI946136A0/en
Publication of FI946136A publication Critical patent/FI946136A/en
Application granted granted Critical
Publication of FI107917B publication Critical patent/FI107917B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/07—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D521/00—Heterocyclic compounds containing unspecified hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

There are described substituted benzenesulphonylureas and -thioureas of the formula I <IMAGE> where R(1) is H, (cyclo)(CH2)a(fluoro)alk(en)yl, R(2) is H, Hal, (fluoro)(mercapto)(CH2)e(cyclo)alk(oxy)(yl), NR(4)R(5) where R(4) and R(5) together are a (CH2)2-7 chain, or R(4), R(5), R(6) are H, (alkyl)(cyclo)(fluoro)alk(en)yl, E is O, S; Y is -[CR(7)2]n-R(3) <IMAGE> B is (C3-C6)-alkenyl, or R(3) is <IMAGE> X is H, Hal, alkyl; Z is Hal, (cyclo)alk(yl)(oxy). Compounds I are used for the treatment of cardiac arrhythmias and for the prevention of sudden heart death caused by arrhythmia and can therefore be used as antiarrhythmics. They are particularly suitable in those cases in which arrhythmias are the result of constriction of a coronary vessel, such as in angina pectoris or in acute cardiac infarct.
FI946136A 1993-12-30 1994-12-28 A process for the preparation of therapeutically useful derivatives of 2-oxo-3-pyrrolinylcarboxamidoethylbenzenesulfonyl urea and thiourea urea FI107917B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4344957A DE4344957A1 (en) 1993-12-30 1993-12-30 Substituted benzenesulfonylureas and thioureas, production processes and possible uses of pharmaceutical preparations based on these compounds
DE4344957 1993-12-30

Publications (3)

Publication Number Publication Date
FI946136A0 FI946136A0 (en) 1994-12-28
FI946136A true FI946136A (en) 1995-07-01
FI107917B FI107917B (en) 2001-10-31

Family

ID=6506518

Family Applications (1)

Application Number Title Priority Date Filing Date
FI946136A FI107917B (en) 1993-12-30 1994-12-28 A process for the preparation of therapeutically useful derivatives of 2-oxo-3-pyrrolinylcarboxamidoethylbenzenesulfonyl urea and thiourea urea

Country Status (19)

Country Link
EP (1) EP0661264B1 (en)
JP (1) JP3718248B2 (en)
KR (1) KR100370307B1 (en)
CN (1) CN1052976C (en)
AT (1) ATE194594T1 (en)
AU (1) AU679136B2 (en)
CA (1) CA2138930C (en)
DE (2) DE4344957A1 (en)
DK (1) DK0661264T3 (en)
ES (1) ES2149234T3 (en)
FI (1) FI107917B (en)
GR (1) GR3034513T3 (en)
HU (1) HU217122B (en)
IL (1) IL112172A (en)
NO (1) NO302750B1 (en)
NZ (1) NZ270265A (en)
PT (1) PT661264E (en)
TW (1) TW436481B (en)
ZA (1) ZA9410380B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19503136A1 (en) * 1995-02-01 1996-08-08 Hoechst Ag Substituted thiophenylsulfonylureas and thioureas, processes for their preparation, their use as medicaments or diagnostic agents and medicaments containing them
KR100324058B1 (en) * 1997-01-29 2002-02-16 디. 제이. 우드, 스피겔 알렌 제이 Sulfonyl Urea Derivatives and Their Use in the Control of Interleukin-1 Activity
DE19832009A1 (en) 1998-07-16 2000-01-20 Hoechst Marion Roussel De Gmbh New 2,5-disubstituted benzenesulfonyl-ureas or -thioureas, used as ATP-sensitive potassium channel blockers for treating cardiovascular disorders such as arrhythmia or cardiac insufficiency
JP2014532654A (en) * 2011-10-26 2014-12-08 シュタイン, エミリー, エイ.STEIN, Emily, A. Agents, methods, and devices that affect neural function
CN103420891B (en) * 2013-06-09 2015-10-21 南通市华峰化工有限责任公司 The synthetic method of type II diabetes medicine glimepiride intermediate benzene sulfanilamide (SN) triphosgene
CN103508932B (en) * 2013-09-22 2015-06-10 江苏德峰药业有限公司 Method for synthesizing diabetes drug-glimepiride
CN103601661B (en) * 2013-09-22 2015-10-21 江苏德峰药业有限公司 The synthetic method of type II diabetes medicine glimepiride triphosgene

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1518874C3 (en) * 1964-10-07 1975-03-13 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Benzenesulfonylureas and process for their preparation
DE2951135A1 (en) * 1979-12-19 1981-06-25 Hoechst Ag, 6230 Frankfurt SULFONYL UREAS, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS AND THEIR USE

Also Published As

Publication number Publication date
NZ270265A (en) 1995-10-26
NO302750B1 (en) 1998-04-20
EP0661264B1 (en) 2000-07-12
TW436481B (en) 2001-05-28
ZA9410380B (en) 1995-08-29
FI107917B (en) 2001-10-31
FI946136A0 (en) 1994-12-28
GR3034513T3 (en) 2000-12-29
EP0661264A1 (en) 1995-07-05
CA2138930A1 (en) 1995-07-01
HU217122B (en) 1999-11-29
KR100370307B1 (en) 2003-10-11
JP3718248B2 (en) 2005-11-24
HUT70830A (en) 1995-11-28
JPH07206807A (en) 1995-08-08
NO945083L (en) 1995-07-03
DE59409440D1 (en) 2000-08-17
IL112172A0 (en) 1995-03-15
HU9403803D0 (en) 1995-02-28
KR950017939A (en) 1995-07-22
CN1052976C (en) 2000-05-31
AU679136B2 (en) 1997-06-19
NO945083D0 (en) 1994-12-29
DK0661264T3 (en) 2000-10-23
IL112172A (en) 1999-03-12
ES2149234T3 (en) 2000-11-01
ATE194594T1 (en) 2000-07-15
DE4344957A1 (en) 1995-07-06
PT661264E (en) 2000-12-29
AU8178994A (en) 1995-07-06
CN1109872A (en) 1995-10-11
CA2138930C (en) 2006-01-17

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