FI944280A - Migraine-resistant cyclobutenedione dione derivatives of indolylalkyl-pyrimidinyl and pyrimidinyl-piperazines - Google Patents
Migraine-resistant cyclobutenedione dione derivatives of indolylalkyl-pyrimidinyl and pyrimidinyl-piperazines Download PDFInfo
- Publication number
- FI944280A FI944280A FI944280A FI944280A FI944280A FI 944280 A FI944280 A FI 944280A FI 944280 A FI944280 A FI 944280A FI 944280 A FI944280 A FI 944280A FI 944280 A FI944280 A FI 944280A
- Authority
- FI
- Finland
- Prior art keywords
- pyrimidinyl
- cyclobutenedione
- indolylalkyl
- piperazines
- migraine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12226693A | 1993-09-16 | 1993-09-16 | |
| US08/277,789 US5521188A (en) | 1993-09-16 | 1994-07-25 | Antimigraine cyclobutenedione derivatives of indolylalkyl-pyridinyl and pyrimidinylpiperazines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI944280A0 FI944280A0 (en) | 1994-09-15 |
| FI944280A true FI944280A (en) | 1995-03-17 |
Family
ID=26820350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI944280A FI944280A (en) | 1993-09-16 | 1994-09-15 | Migraine-resistant cyclobutenedione dione derivatives of indolylalkyl-pyrimidinyl and pyrimidinyl-piperazines |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0645385A1 (en) |
| JP (1) | JPH07196648A (en) |
| CN (1) | CN1112561A (en) |
| AU (1) | AU673098B2 (en) |
| CA (1) | CA2130078A1 (en) |
| CZ (1) | CZ224894A3 (en) |
| FI (1) | FI944280A (en) |
| HU (1) | HUT70614A (en) |
| IL (1) | IL110944A (en) |
| NO (1) | NO943428L (en) |
| NZ (1) | NZ264371A (en) |
| PL (1) | PL305047A1 (en) |
| SG (1) | SG52295A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5466712A (en) * | 1994-11-04 | 1995-11-14 | American Home Products Corporation | Substituted n-aryl-1,2-diaminocyclobutene-3,4-diones |
| US5618816A (en) * | 1995-03-02 | 1997-04-08 | Bristol-Myers Squibb Company | Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridnyl and pyrimidinylpiperazines |
| US5846999A (en) * | 1996-07-17 | 1998-12-08 | American Home Products Corporation | Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones |
| US5763474A (en) * | 1996-07-17 | 1998-06-09 | American Home Products Corporation | Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones |
| US5750574A (en) * | 1996-07-17 | 1998-05-12 | American Home Products Corporation | Fluorinated N-arylmethylamino derivatives of cyclobutene-3,4-diones |
| US5780505A (en) * | 1996-07-17 | 1998-07-14 | American Home Products Corporation | Substituted N-arylmethylamino derivatives of cyclobutene-3, 4-diones |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3468882A (en) * | 1966-10-07 | 1969-09-23 | Sterling Drug Inc | Phenylhydrazone derivatives as intermediates for preparing indoles |
| US4954502A (en) * | 1988-06-10 | 1990-09-04 | Bristol-Myers Squibb Company | 1-indolyalkyl-4-(substituted-pyridinyl)piperazines |
| GB8924373D0 (en) * | 1989-10-30 | 1989-12-20 | Beecham Group Plc | Novel compounds |
| US5077293A (en) * | 1990-06-29 | 1991-12-31 | Bristol-Myers Squibb Co. | 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines |
| CA2043709C (en) * | 1990-06-29 | 2002-01-22 | David W. Smith | Antimigraine alkoxypyrimidine derivatives |
| CA2084531A1 (en) * | 1991-12-19 | 1993-06-20 | David W. Smith | Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines |
| US5627191A (en) * | 1992-07-10 | 1997-05-06 | The Boots Company Plc | Therapeutic agents |
-
1994
- 1994-08-12 CA CA002130078A patent/CA2130078A1/en not_active Abandoned
- 1994-09-02 NZ NZ264371A patent/NZ264371A/en unknown
- 1994-09-13 IL IL11094494A patent/IL110944A/en active IP Right Grant
- 1994-09-14 CZ CZ942248A patent/CZ224894A3/en unknown
- 1994-09-14 PL PL94305047A patent/PL305047A1/en unknown
- 1994-09-15 EP EP94306778A patent/EP0645385A1/en not_active Ceased
- 1994-09-15 CN CN94115334A patent/CN1112561A/en active Pending
- 1994-09-15 HU HU9402648A patent/HUT70614A/en unknown
- 1994-09-15 FI FI944280A patent/FI944280A/en unknown
- 1994-09-15 SG SG1996002369A patent/SG52295A1/en unknown
- 1994-09-15 AU AU72975/94A patent/AU673098B2/en not_active Ceased
- 1994-09-15 NO NO943428A patent/NO943428L/en unknown
- 1994-09-16 JP JP6221955A patent/JPH07196648A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FI944280A0 (en) | 1994-09-15 |
| NZ264371A (en) | 1996-06-25 |
| JPH07196648A (en) | 1995-08-01 |
| CN1112561A (en) | 1995-11-29 |
| HU9402648D0 (en) | 1994-11-28 |
| HUT70614A (en) | 1995-10-30 |
| NO943428L (en) | 1995-03-17 |
| AU673098B2 (en) | 1996-10-24 |
| PL305047A1 (en) | 1995-03-20 |
| SG52295A1 (en) | 1998-09-28 |
| CZ224894A3 (en) | 1995-08-16 |
| CA2130078A1 (en) | 1995-03-17 |
| IL110944A0 (en) | 1994-11-28 |
| IL110944A (en) | 1999-06-20 |
| NO943428D0 (en) | 1994-09-15 |
| AU7297594A (en) | 1995-03-30 |
| EP0645385A1 (en) | 1995-03-29 |
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