FI944076A - Process for Preparation of N- (3-Hydroxy-4-piperidinyl) (dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxine) carboxamide derivatives and intermediates - Google Patents

Process for Preparation of N- (3-Hydroxy-4-piperidinyl) (dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxine) carboxamide derivatives and intermediates Download PDF

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Publication number
FI944076A
FI944076A FI944076A FI944076A FI944076A FI 944076 A FI944076 A FI 944076A FI 944076 A FI944076 A FI 944076A FI 944076 A FI944076 A FI 944076A FI 944076 A FI944076 A FI 944076A
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FI
Finland
Prior art keywords
intermediates
hydrogen
dihydrobenzodioxine
dihydrobenzofuran
benzopyran
Prior art date
Application number
FI944076A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI944076A0 (en
FI101623B (en
FI101623B1 (en
Inventor
Daele Georges Henri Paul Van
Den Keybus Frans Maria Alf Van
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FI901421A external-priority patent/FI101624B1/en
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Priority to FI944076A priority Critical patent/FI101623B1/en
Publication of FI944076A0 publication Critical patent/FI944076A0/en
Publication of FI944076A publication Critical patent/FI944076A/en
Application granted granted Critical
Publication of FI101623B publication Critical patent/FI101623B/en
Publication of FI101623B1 publication Critical patent/FI101623B1/en

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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

The invention relates to a process for preparing piperidine derivatives II, in which A is -CH2-CH2-, -CH2 CH2-CH2-, -CH2-CH2-CH2-CH2, -CH2-O-, -CH2-CH2-O- or -CH2 CH2-CH2-O-, in which one or two hydrogen atoms can be replaced by an alkyl radical; R1 is hydrogen, halogen, alkylsulphonyl or aminosulphonyl; R2 is hydrogen, amino, mono- or dialkylamino, arylalkylamino or alkylcarbonylamino; and R3 and R4 are both, independently, hydrogen or alkyl. The compounds II can be used therapeutically as agents which act on mobility in the gastrointestinal region. They can also be used a starting substances when preparing other therapeutically active compounds. The invention also relates to intermediates XVII in which P1 is a protecting group. <IMAGE> <IMAGE>
FI944076A 1989-03-22 1994-09-05 Process for preparing therapeutically useful N-(3-hydroxy 4-piperidinyl)(dihydrobenzofuran-, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives and intermediates FI101623B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI944076A FI101623B1 (en) 1989-03-22 1994-09-05 Process for preparing therapeutically useful N-(3-hydroxy 4-piperidinyl)(dihydrobenzofuran-, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives and intermediates

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US32694189A 1989-03-22 1989-03-22
US32694189 1989-03-22
FI901421 1990-03-21
FI901421A FI101624B1 (en) 1989-03-22 1990-03-21 Process for the preparation of therapeutically useful N- (3-hydroxy-4-piperidinyl) (dihydrobenzofuran, dihydro-2H-benzopyranic or dihydrobenzodioxine) carboxamide derivatives and intermediate
FI944076A FI101623B1 (en) 1989-03-22 1994-09-05 Process for preparing therapeutically useful N-(3-hydroxy 4-piperidinyl)(dihydrobenzofuran-, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives and intermediates
FI944076 1994-09-05

Publications (4)

Publication Number Publication Date
FI944076A0 FI944076A0 (en) 1994-09-05
FI944076A true FI944076A (en) 1994-09-05
FI101623B FI101623B (en) 1998-07-31
FI101623B1 FI101623B1 (en) 1998-07-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
FI944076A FI101623B1 (en) 1989-03-22 1994-09-05 Process for preparing therapeutically useful N-(3-hydroxy 4-piperidinyl)(dihydrobenzofuran-, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives and intermediates

Country Status (1)

Country Link
FI (1) FI101623B1 (en)

Also Published As

Publication number Publication date
FI944076A0 (en) 1994-09-05
FI101623B (en) 1998-07-31
FI101623B1 (en) 1998-07-31

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