FI934273A - Basical quaternary amate, production and pharmaceutical preparations in the Netherlands - Google Patents

Basical quaternary amate, production and pharmaceutical preparations in the Netherlands Download PDF

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Publication number
FI934273A
FI934273A FI934273A FI934273A FI934273A FI 934273 A FI934273 A FI 934273A FI 934273 A FI934273 A FI 934273A FI 934273 A FI934273 A FI 934273A FI 934273 A FI934273 A FI 934273A
Authority
FI
Finland
Prior art keywords
group
alkyl
basical
amate
netherlands
Prior art date
Application number
FI934273A
Other languages
Finnish (fi)
Other versions
FI114474B (en
FI934273A0 (en
Inventor
Xavier Emonds-Alt
Patrick Gueule
Vincenzo Proietto
Broeck Didier Van
Original Assignee
Sanofi Elf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Elf filed Critical Sanofi Elf
Publication of FI934273A0 publication Critical patent/FI934273A0/en
Publication of FI934273A publication Critical patent/FI934273A/en
Application granted granted Critical
Publication of FI114474B publication Critical patent/FI114474B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Indole Compounds (AREA)

Abstract

The invention relates to basic quaternary amides of formula <IMAGE> in which - Ar represents an optionally substituted mono-, di- or tricyclic heteroaromatic or aromatic group; - T represents a direct bond, a hydroxymethylene group, an alkoxymethylene group in which the alkoxy group is C1-C4 or a C1-C5 alkylene group; - Ar' represents a phenyl which is unsubstituted or substituted one or a number of times, a thienyl, a benzothienyl, a naphthyl or an indolyl; - R represents hydrogen, a C1-C4 alkyl, an omega -(C1-C4)alkoxy(C2-C4)alkyl or an omega -(C1-C4)alkanoyloxy(C2-C 4)alkyl, - Q represents hydrogen; - or else Q and R, together, form a 1,2-ethylene, 1,3-propylene or 1,4-butylene group; - Am<(+)> represents the radical <IMAGE> in which X1, X2 and X3, together and with the nitrogen atom to which they are bonded, form an azabicyclic or azatricyclic system optionally substituted by a phenyl group; - A<(-)> is a pharmaceutically acceptable anion. These compounds are useful in the preparation of medicaments intended for the treatment of pathologies involving the tachykinin system.
FI934273A 1992-09-30 1993-09-29 Process for the preparation of therapeutically useful basic quaternary amides FI114474B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9212083 1992-09-30
FR9212083A FR2696178B1 (en) 1992-09-30 1992-09-30 Quaternary basic amides, process for their preparation and pharmaceutical compositions containing them.

Publications (3)

Publication Number Publication Date
FI934273A0 FI934273A0 (en) 1993-09-29
FI934273A true FI934273A (en) 1994-03-31
FI114474B FI114474B (en) 2004-10-29

Family

ID=9434374

Family Applications (1)

Application Number Title Priority Date Filing Date
FI934273A FI114474B (en) 1992-09-30 1993-09-29 Process for the preparation of therapeutically useful basic quaternary amides

Country Status (27)

Country Link
EP (1) EP0591040B1 (en)
JP (2) JP2857041B2 (en)
KR (1) KR100279084B1 (en)
CN (1) CN1036652C (en)
AT (1) ATE176469T1 (en)
AU (1) AU674875B2 (en)
BR (1) BR9303982A (en)
CA (1) CA2107432C (en)
CZ (1) CZ287272B6 (en)
DE (1) DE69323375T2 (en)
DK (1) DK0591040T3 (en)
ES (1) ES2130238T3 (en)
FI (1) FI114474B (en)
FR (1) FR2696178B1 (en)
GR (1) GR3030000T3 (en)
HU (2) HU215848B (en)
IL (1) IL107158A0 (en)
MX (1) MX9306024A (en)
MY (1) MY108881A (en)
NO (1) NO304888B1 (en)
NZ (1) NZ248821A (en)
OA (1) OA09869A (en)
RU (1) RU2120436C1 (en)
SG (1) SG47807A1 (en)
SI (1) SI9300513B (en)
TW (1) TW242625B (en)
ZA (1) ZA937276B (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583134A (en) * 1992-09-30 1996-12-10 Sanofi 1-azoniabicyclo[2.2.2] octanes and pharmaceutical compositions in which they are present
FR2717802B1 (en) * 1994-03-25 1996-06-21 Sanofi Sa New aromatic compounds, process for their preparation and pharmaceutical compositions containing them.
FR2717804B1 (en) * 1994-03-25 1996-06-21 Sanofi Sa Salts of substituted nitrogen heteroaromatic compounds, process for their preparation and pharmaceutical compositions containing them.
IL113472A0 (en) 1994-04-29 1995-07-31 Lilly Co Eli Non-peptidyl tachykinin receptor antogonists
WO1996001819A1 (en) 1994-07-12 1996-01-25 Eli Lilly And Company Heterocyclic tachykinin receptor antagonists
FR2725900B1 (en) * 1994-10-21 1997-07-18 Sanofi Sa USE OF NK1 RECEPTOR ANTAGONISTS FOR THE PREPARATION OF DRUGS WITH CARDIOREGULATORY ACTION
US6008223A (en) * 1994-10-27 1999-12-28 Zeneca Limited Therapeutic compounds
GB9421709D0 (en) * 1994-10-27 1994-12-14 Zeneca Ltd Therapeutic compounds
CA2162786A1 (en) * 1994-11-22 1996-05-23 Philip Arthur Hipskind Heterocyclic tachykinin receptor antagonists
FR2729954B1 (en) 1995-01-30 1997-08-01 Sanofi Sa SUBSTITUTED HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2729951B1 (en) * 1995-01-30 1997-04-18 Sanofi Sa NOVEL HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2729952B1 (en) * 1995-01-30 1997-04-18 Sanofi Sa SUBSTITUTED HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2751654B1 (en) * 1996-07-26 1998-10-23 Sanofi Sa SUBSTITUTED HETEROCYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5654316A (en) * 1995-06-06 1997-08-05 Schering Corporation Piperidine derivatives as neurokinin antagonists
WO1996039383A1 (en) * 1995-06-06 1996-12-12 Schering Corporation Substituted benzene-fused hetero- and carbocyclics as neurokinin antagonists
FR2745811B1 (en) * 1996-03-07 1998-05-22 Sanofi Sa DISSUBSTITUTED GLUTARIMIDE PROCESS FOR ITS PREPARATION, AND ITS USE
AU3149297A (en) * 1996-05-24 1997-12-09 Eli Lilly And Company Methods of treating hypertension
US5691362A (en) * 1996-06-05 1997-11-25 Schering-Plough Corporation Substituted benzene-fused hetero- and carbocyclics as nuerokinin antagonists
GB9617730D0 (en) * 1996-08-23 1996-10-02 Pfizer Ltd Quarternary ammonium compounds
FR2759584B1 (en) * 1997-02-17 1999-06-11 Sanofi Sa PHARMACEUTICAL COMPOSITION FOR THE ORAL ADMINISTRATION OF HETEROCYCLIC COMPOUNDS IN QUATERNARY AMMONIUM FORM
FR2759585B1 (en) * 1997-02-17 1999-06-11 Sanofi Sa PHARMACEUTICAL FORMULATIONS PRESENTED IN A DRY FORM FOR THE ORAL ADMINISTRATION OF A CYCLIC QUATERNARY AMMONIUM COMPOUND
AU744261B2 (en) * 1997-04-24 2002-02-21 Merck Sharp & Dohme Limited Use of NK-1 receptor antagonists for treating eating disorders
GB9712882D0 (en) * 1997-06-18 1997-08-20 Pfizer Ltd Quaternary ammonium compounds
CA2298777A1 (en) * 1997-08-04 1999-02-18 Merck Sharp & Dohme Limited Use of nk-1 receptor antagonists for treating mania
GB9716463D0 (en) * 1997-08-04 1997-10-08 Merck Sharp & Dohme Therapeutic agents
GB9716457D0 (en) * 1997-08-04 1997-10-08 Merck Sharp & Dohme Therapeutic agents
CA2298779A1 (en) * 1997-08-04 1999-02-18 Merck Sharp & Dohme Limited Use of nk-1 receptor antagonists for treating aggressive behaviour disorders
GB9816897D0 (en) * 1998-08-04 1998-09-30 Merck Sharp & Dohme Therapeutic use
GB9927125D0 (en) 1999-11-16 2000-01-12 Univ Reading The Placental human neurokinin B precursor
WO2005080339A1 (en) * 2004-02-25 2005-09-01 Sankyo Company, Limited Sulfonyloxy derivatives
EP1868434A4 (en) 2005-03-22 2011-10-26 Azevan Pharmaceuticals Inc Beta-lactamylalkanoic acids for treating premenstrual disorders
US8048874B2 (en) 2005-07-19 2011-11-01 Azevan Pharmaceuticals, Inc. Beta-lactamyl phenylalanine, cysteine, and serine vasopressin antagonists
CA2676357A1 (en) 2007-01-24 2008-07-31 Glaxo Group Limited Pharmaceutical compositions comprising 3, 5-diamin0-6- (2, 3-dichl0phenyl) -l, 2, 4-triazine or r (-) -2, 4-diamino-5- (2, 3-dichlorophenyl) -6-fluoromethyl pyrimidine and an nk1
UA105182C2 (en) 2008-07-03 2014-04-25 Ньюрексон, Інк. Benzoxazines, benzothiazines, and related compounds having nos inhibitory activity
EP2587919B1 (en) 2010-07-01 2017-12-13 Azevan Pharmaceuticals, Inc. Methods for treating post traumatic stress disorder
BR112016022575A2 (en) 2014-03-28 2017-08-15 Azevan Pharmaceuticals Inc COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
EP3556435B1 (en) * 2016-12-14 2020-10-28 Beijing Showby Pharmaceutical Co., Ltd. Class of bifunctional compounds with quaternary ammonium salt structure
AU2018333051B2 (en) 2017-09-15 2024-03-21 Azevan Pharmaceuticals, Inc. Compositions and methods for treating brain injury

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI97540C (en) * 1989-11-06 1997-01-10 Sanofi Sa Process for the preparation of therapeutically useful aromatically substituted piperidine and piperazine derivatives
FR2666185B1 (en) * 1990-08-21 1992-12-04 Sgs Thomson Microelectronics INTERPOLATION ANALOG / DIGITAL CONVERTER.
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ATE176469T1 (en) 1999-02-15
RU2120436C1 (en) 1998-10-20
HU211889A9 (en) 1995-12-28
MX9306024A (en) 1994-03-31
FR2696178B1 (en) 1994-12-30
TW242625B (en) 1995-03-11
AU674875B2 (en) 1997-01-16
BR9303982A (en) 1994-10-25
CA2107432A1 (en) 1994-03-31
AU4870893A (en) 1994-04-14
HU9302770D0 (en) 1993-12-28
SI9300513B (en) 2002-02-28
SG47807A1 (en) 1998-04-17
CA2107432C (en) 2000-04-04
SI9300513A (en) 1994-06-30
DE69323375D1 (en) 1999-03-18
JP3243212B2 (en) 2002-01-07
EP0591040A1 (en) 1994-04-06
CZ203593A3 (en) 1994-04-13
NO933481L (en) 1994-04-05
ZA937276B (en) 1994-04-25
JP2857041B2 (en) 1999-02-10
FI114474B (en) 2004-10-29
FI934273A0 (en) 1993-09-29
NZ248821A (en) 1995-10-26
NO304888B1 (en) 1999-03-01
OA09869A (en) 1994-08-15
GR3030000T3 (en) 1999-07-30
HU215848B (en) 1999-04-28
CN1036652C (en) 1997-12-10
JPH06211850A (en) 1994-08-02
KR100279084B1 (en) 2001-01-15
JPH10175976A (en) 1998-06-30
FR2696178A1 (en) 1994-04-01
IL107158A0 (en) 1993-12-28
DK0591040T3 (en) 1999-09-20
EP0591040B1 (en) 1999-02-03
CZ287272B6 (en) 2000-10-11
MY108881A (en) 1996-11-30
NO933481D0 (en) 1993-09-29
KR940007026A (en) 1994-04-26
DE69323375T2 (en) 1999-06-24
HUT65759A (en) 1994-07-28
CN1088582A (en) 1994-06-29
ES2130238T3 (en) 1999-07-01

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