US5364943A
(en)
*
|
1991-11-27 |
1994-11-15 |
Pfizer Inc. |
Preparation of substituted piperidines
|
ES2063507T3
(en)
*
|
1990-06-01 |
1995-01-01 |
Pfizer |
3-AMINO-2-ARYL-QUINUCLIDINES, PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
|
US5521220A
(en)
*
|
1991-11-12 |
1996-05-28 |
Pfizer Inc. |
Acyclic ethylenediamine derivatives
|
DK0641328T3
(en)
*
|
1992-05-18 |
2002-05-21 |
Pfizer |
Bridged, azabicyclic derivatives as substance P antagonists
|
US6048859A
(en)
|
1992-06-29 |
2000-04-11 |
Merck & Co., Inc. |
Morpholine and thiomorpholine tachykinin receptor antagonists
|
US5637699A
(en)
*
|
1992-06-29 |
1997-06-10 |
Merck & Co., Inc. |
Process for preparing morpholine tachykinin receptor antagonists
|
US5719147A
(en)
*
|
1992-06-29 |
1998-02-17 |
Merck & Co., Inc. |
Morpholine and thiomorpholine tachykinin receptor antagonists
|
WO1994003445A1
(en)
*
|
1992-08-04 |
1994-02-17 |
Pfizer Inc. |
3-benzylamino-2-phenyl-piperidine derivatives as substance p receptor antagonists
|
GB9216911D0
(en)
*
|
1992-08-10 |
1992-09-23 |
Merck Sharp & Dohme |
Therapeutic agents
|
US5387595A
(en)
*
|
1992-08-26 |
1995-02-07 |
Merck & Co., Inc. |
Alicyclic compounds as tachykinin receptor antagonists
|
US5393762A
(en)
*
|
1993-06-04 |
1995-02-28 |
Pfizer Inc. |
Pharmaceutical agents for treatment of emesis
|
IL112778A0
(en)
*
|
1994-03-04 |
1995-05-26 |
Merck & Co Inc |
Substituted heterocycles, their preparation and pharmaceutical compositions containing them
|
IL116249A
(en)
*
|
1994-12-12 |
2003-07-06 |
Pfizer |
Nk-1 receptor antagonists for the treatment of neuronal damage and stroke
|
FR2728169A1
(en)
|
1994-12-19 |
1996-06-21 |
Oreal |
USE OF A SUBSTANCE P ANTAGONIST FOR THE TREATMENT OF PRURITUS AND EYE OR PALPEBRAL DYSESTHESIA
|
FR2728165A1
(en)
|
1994-12-19 |
1996-06-21 |
Oreal |
USE OF AN ANTAGONIST OF SUBSTANCE P FOR THE TREATMENT OF SKIN REDNESS OF NEUROGENIC ORIGIN
|
FR2728166A1
(en)
|
1994-12-19 |
1996-06-21 |
Oreal |
TOPICAL COMPOSITION CONTAINING AN ANTAGONIST OF SUBSTANCE P
|
TW458774B
(en)
|
1995-10-20 |
2001-10-11 |
Pfizer |
Antiemetic pharmaceutical compositions
|
FR2741262B1
(en)
|
1995-11-20 |
1999-03-05 |
Oreal |
USE OF A TNF-ALPHA ANTAGONIST FOR THE TREATMENT OF CUTANEOUS REDNESS OF NEUROGENIC ORIGIN
|
BR0015320A
(en)
|
1999-11-03 |
2002-07-09 |
Albany Molecular Res Inc |
Compound, composition, methods of treating a disorder that is created by, or is dependent on, the decreased availability of serotonin, norepinephrine or dopamine, to inhibit the uptake of synaptic serotonin, dopamine and norepinephrine in a patient in need thereof, and kit
|
US7163949B1
(en)
|
1999-11-03 |
2007-01-16 |
Amr Technology, Inc. |
4-phenyl substituted tetrahydroisoquinolines and use thereof
|
US7084152B2
(en)
|
2000-07-11 |
2006-08-01 |
Amr Technology, Inc. |
4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof
|
CA2573271C
(en)
|
2004-07-15 |
2015-10-06 |
Amr Technology, Inc. |
Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
|
EP1888050B1
(en)
|
2005-05-17 |
2012-03-21 |
Merck Sharp & Dohme Ltd. |
cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid for the treatment of cancer
|
JP5258561B2
(en)
|
2005-07-15 |
2013-08-07 |
アルバニー モレキュラー リサーチ, インコーポレイテッド |
Aryl and heteroaryl substituted tetrahydrobenzazepines and their use to block reuptake of norepinephrine, dopamine and serotonin
|
KR20080048502A
(en)
|
2005-09-29 |
2008-06-02 |
머크 앤드 캄파니 인코포레이티드 |
Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
|
GB0603041D0
(en)
|
2006-02-15 |
2006-03-29 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
WO2008039327A2
(en)
|
2006-09-22 |
2008-04-03 |
Merck & Co., Inc. |
Method of treatment using fatty acid synthesis inhibitors
|
US20110218176A1
(en)
|
2006-11-01 |
2011-09-08 |
Barbara Brooke Jennings-Spring |
Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
|
MX2009007200A
(en)
|
2007-01-10 |
2009-07-15 |
Angeletti P Ist Richerche Bio |
Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors.
|
JP5319518B2
(en)
|
2007-04-02 |
2013-10-16 |
Msd株式会社 |
Indoledione derivative
|
AU2008269154B2
(en)
|
2007-06-27 |
2014-06-12 |
Merck Sharp & Dohme Llc |
4-carboxybenzylamino derivatives as histone deacetylase inhibitors
|
JP2011515343A
(en)
|
2008-03-03 |
2011-05-19 |
タイガー ファーマテック |
Tyrosine kinase inhibitor
|
AR071997A1
(en)
|
2008-06-04 |
2010-07-28 |
Bristol Myers Squibb Co |
CRYSTAL FORM OF 6 - ((4S) -2-METHYL-4- (2-NAFTIL) -1,2,3,4-TETRAHYDROISOQUINOLIN-7-IL) PIRIDAZIN-3-AMINA
|
US9156812B2
(en)
|
2008-06-04 |
2015-10-13 |
Bristol-Myers Squibb Company |
Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
|
UA105182C2
(en)
|
2008-07-03 |
2014-04-25 |
Ньюрексон, Інк. |
Benzoxazines, benzothiazines, and related compounds having nos inhibitory activity
|
WO2010114780A1
(en)
|
2009-04-01 |
2010-10-07 |
Merck Sharp & Dohme Corp. |
Inhibitors of akt activity
|
KR20120023072A
(en)
|
2009-05-12 |
2012-03-12 |
브리스톨-마이어스 스큅 컴퍼니 |
Crystalline forms of (s)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorohphenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
|
WO2010132437A1
(en)
|
2009-05-12 |
2010-11-18 |
Albany Molecular Research, Inc. |
Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
|
AU2010247763B2
(en)
|
2009-05-12 |
2015-12-24 |
Albany Molecular Research, Inc. |
7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof
|
EA023838B1
(en)
|
2009-10-14 |
2016-07-29 |
Мерк Шарп Энд Домэ Корп. |
SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF
|
EP2584903B1
(en)
|
2010-06-24 |
2018-10-24 |
Merck Sharp & Dohme Corp. |
Novel heterocyclic compounds as erk inhibitors
|
WO2012018754A2
(en)
|
2010-08-02 |
2012-02-09 |
Merck Sharp & Dohme Corp. |
RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
CA2807307C
(en)
|
2010-08-17 |
2021-02-09 |
Merck Sharp & Dohme Corp. |
Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina)
|
EP2608669B1
(en)
|
2010-08-23 |
2016-06-22 |
Merck Sharp & Dohme Corp. |
NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
|
US8946216B2
(en)
|
2010-09-01 |
2015-02-03 |
Merck Sharp & Dohme Corp. |
Indazole derivatives useful as ERK inhibitors
|
EP2615916B1
(en)
|
2010-09-16 |
2017-01-04 |
Merck Sharp & Dohme Corp. |
Fused pyrazole derivatives as novel erk inhibitors
|
US9260471B2
(en)
|
2010-10-29 |
2016-02-16 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
|
EP2654748B1
(en)
|
2010-12-21 |
2016-07-27 |
Merck Sharp & Dohme Corp. |
Indazole derivatives useful as erk inhibitors
|
AU2012245971A1
(en)
|
2011-04-21 |
2013-10-17 |
Piramal Enterprises Limited |
A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
|
US9023865B2
(en)
|
2011-10-27 |
2015-05-05 |
Merck Sharp & Dohme Corp. |
Compounds that are ERK inhibitors
|
EP3453762B1
(en)
|
2012-05-02 |
2021-04-21 |
Sirna Therapeutics, Inc. |
Short interfering nucleic acid (sina) compositions
|
JP6280554B2
(en)
|
2012-09-28 |
2018-02-14 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
Novel compounds that are ERK inhibitors
|
ME02925B
(en)
|
2012-11-28 |
2018-04-20 |
Merck Sharp & Dohme |
Compositions and methods for treating cancer
|
TW201429969A
(en)
|
2012-12-20 |
2014-08-01 |
Merck Sharp & Dohme |
Substituted imidazopyridines as HDM2 inhibitors
|
EP2951180B1
(en)
|
2013-01-30 |
2018-05-02 |
Merck Sharp & Dohme Corp. |
2,6,7,8 substituted purines as hdm2 inhibitors
|
US20160194368A1
(en)
|
2013-09-03 |
2016-07-07 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
WO2019094311A1
(en)
|
2017-11-08 |
2019-05-16 |
Merck Sharp & Dohme Corp. |
Prmt5 inhibitors
|
US11993602B2
(en)
|
2018-08-07 |
2024-05-28 |
Merck Sharp & Dohme Llc |
PRMT5 inhibitors
|
EP3833667B1
(en)
|
2018-08-07 |
2024-03-13 |
Merck Sharp & Dohme LLC |
Prmt5 inhibitors
|