FI925460A - PROTEIN D - ETT IGD-BINDANDE PROTEIN AV PFEIFFERS INFLUENSAPROTEIN - Google Patents

PROTEIN D - ETT IGD-BINDANDE PROTEIN AV PFEIFFERS INFLUENSAPROTEIN Download PDF

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Publication number
FI925460A
FI925460A FI925460A FI925460A FI925460A FI 925460 A FI925460 A FI 925460A FI 925460 A FI925460 A FI 925460A FI 925460 A FI925460 A FI 925460A FI 925460 A FI925460 A FI 925460A
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FI
Finland
Prior art keywords
protein
influenzae
igd
pfeiffers
influensaprotein
Prior art date
Application number
FI925460A
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Finnish (fi)
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FI109029B (en
FI925460A0 (en
Inventor
Arne Forsgren
Original Assignee
Arne Forsgren
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20379641&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI925460(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Arne Forsgren filed Critical Arne Forsgren
Publication of FI925460A publication Critical patent/FI925460A/en
Publication of FI925460A0 publication Critical patent/FI925460A0/en
Application granted granted Critical
Publication of FI109029B publication Critical patent/FI109029B/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1242—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/115831—Condition or time responsive
    • Y10T436/116664—Condition or time responsive with automated titrator

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A novel surface exposed protein of Haemophilus influenzae or related Haemophilus species is described. The protein named protein D is an Ig receptor for human IgD and has an apparent molecular weight of 42,000. Protein D can be detected in all of 116 encapsulated and non-encapsulated isolates of H. influenzae studied. The protein from all strains shows in addition to the same apparent molecular weight immunogenic similarities since protein D from all strains interacts with three different mouse monoclonal antibodies and monoclonal human IgD. A method for purification of protein D is described. Cloning of the protein D gene from H. influenzae in E. coli is described as well as the nucleotide sequence and the deduced amino acid sequence.
FI925460A 1990-05-31 1992-11-30 Method for the production of surface protein in strains of Haemophilus influenzae or related strains of Haemophilus species FI109029B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE9001949 1990-05-31
SE9001949A SE466259B (en) 1990-05-31 1990-05-31 PROTEIN D - AN IGD BINDING PROTEIN FROM HAEMOPHILUS INFLUENZAE, AND THE USE OF THIS FOR ANALYSIS, VACCINES AND PURPOSE
SE9100129 1991-01-15
PCT/SE1991/000129 WO1991018926A1 (en) 1990-05-31 1991-02-21 PROTEIN D - AN IgD-BINDING PROTEIN OF HAEMOPHILUS INFLUENZAE

Publications (3)

Publication Number Publication Date
FI925460A true FI925460A (en) 1992-11-30
FI925460A0 FI925460A0 (en) 1992-11-30
FI109029B FI109029B (en) 2002-05-15

Family

ID=20379641

Family Applications (1)

Application Number Title Priority Date Filing Date
FI925460A FI109029B (en) 1990-05-31 1992-11-30 Method for the production of surface protein in strains of Haemophilus influenzae or related strains of Haemophilus species

Country Status (15)

Country Link
US (9) US5989828A (en)
EP (1) EP0594610B1 (en)
JP (1) JP3066072B2 (en)
AT (1) ATE170531T1 (en)
AU (1) AU650011B2 (en)
CA (1) CA2083172C (en)
DE (3) DE69130116T2 (en)
DK (1) DK0594610T3 (en)
ES (1) ES2119776T3 (en)
FI (1) FI109029B (en)
LU (2) LU91610I2 (en)
NL (2) NL300410I1 (en)
NO (4) NO309721B1 (en)
SE (1) SE466259B (en)
WO (1) WO1991018926A1 (en)

Families Citing this family (278)

* Cited by examiner, † Cited by third party
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