FI924529A7 - Nya 17b-substituerade aza-androstan-derivat - Google Patents

Nya 17b-substituerade aza-androstan-derivat Download PDF

Info

Publication number
FI924529A7
FI924529A7 FI924529A FI924529A FI924529A7 FI 924529 A7 FI924529 A7 FI 924529A7 FI 924529 A FI924529 A FI 924529A FI 924529 A FI924529 A FI 924529A FI 924529 A7 FI924529 A7 FI 924529A7
Authority
FI
Finland
Prior art keywords
substituerade
nya
aza
androstan
derivatives
Prior art date
Application number
FI924529A
Other languages
English (en)
Finnish (fi)
Other versions
FI924529A0 (fi
Inventor
Michel Biollaz
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of FI924529A0 publication Critical patent/FI924529A0/fi
Publication of FI924529A7 publication Critical patent/FI924529A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI924529A 1991-10-09 1992-10-07 Nya 17b-substituerade aza-androstan-derivat FI924529A7 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH297891 1991-10-09

Publications (2)

Publication Number Publication Date
FI924529A0 FI924529A0 (fi) 1992-10-07
FI924529A7 true FI924529A7 (fi) 1993-04-10

Family

ID=4245915

Family Applications (1)

Application Number Title Priority Date Filing Date
FI924529A FI924529A7 (fi) 1991-10-09 1992-10-07 Nya 17b-substituerade aza-androstan-derivat

Country Status (19)

Country Link
US (2) US5304562A (enExample)
EP (1) EP0538192B1 (enExample)
JP (1) JPH05213989A (enExample)
KR (1) KR930007969A (enExample)
AT (1) ATE152121T1 (enExample)
AU (1) AU657579B2 (enExample)
CA (1) CA2080054A1 (enExample)
DE (1) DE59208383D1 (enExample)
DK (1) DK0538192T3 (enExample)
ES (1) ES2101073T3 (enExample)
FI (1) FI924529A7 (enExample)
GR (1) GR3024013T3 (enExample)
HU (1) HUT62600A (enExample)
IL (1) IL103361A (enExample)
MX (1) MX9205792A (enExample)
NO (1) NO923911L (enExample)
NZ (1) NZ244640A (enExample)
TW (1) TW263513B (enExample)
ZA (1) ZA927747B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5304562A (en) * 1991-10-09 1994-04-19 Ciba-Geigy Corporation 17β-substituted Aza-androstane derivatives
WO1993023419A1 (en) * 1992-05-20 1993-11-25 Merck & Co., Inc. NEW 7β-SUBSTITUTED-4-AZA-5α-CHOLESTAN-ONES AS 5α-REDUCTASE INHIBITORS
WO1993023039A1 (en) * 1992-05-20 1993-11-25 Merck & Co., Inc. Substituted 4-aza-5a-androstan-ones as 5a-reductase inhibitors
GB9210880D0 (en) * 1992-05-21 1992-07-08 Smithkline Beecham Corp Compounds
GB9216284D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives
HU212459B (en) * 1992-10-02 1996-06-28 Richter Gedeon Vegyeszet Process for producing new 17-beta-substituted 4-aza-androstane-derivatives and pharmaceutical compositions containing them
DE69329933T2 (de) * 1992-10-06 2001-07-19 Merck & Co., Inc. 17-beta-carboxanilid derivate von 4-aza-5-alpha-androstan-3-one als 5-alpha-reduktase-hemmende arzneimittel
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
TW408127B (en) * 1993-09-17 2000-10-11 Glaxo Inc Androstenones
US5470976A (en) * 1994-09-07 1995-11-28 Merck & Co., Inc. Process for the stereoselective reduction of steroid enelactams
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
US5595996A (en) * 1994-10-25 1997-01-21 Merck & Co., Inc. 7-substituted 4-aza cholanic acid derivatives and their use
US5656613A (en) * 1995-01-04 1997-08-12 Merck & Co., Inc. Treatment of hyperandrogenic conditions
EP0859761A4 (en) * 1995-09-15 2000-01-26 Merck & Co Inc 4-AZASTEROIDS FOR TREATING HYPERANDROGEN STATES
USRE39056E1 (en) * 1995-09-15 2006-04-04 Merck & Co, Inc. 4-Azasteroids for treatment of hyperandrogenic conditions
US5998427A (en) * 1998-05-14 1999-12-07 Glaxo Wellcome Inc. Androstenones
US6645974B2 (en) 2001-07-31 2003-11-11 Merck & Co., Inc. Androgen receptor modulators and methods for use thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4377584A (en) * 1978-04-13 1983-03-22 Merck & Co., Inc. 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
US5049562A (en) * 1984-02-27 1991-09-17 Merck & Co., Inc. 17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α-reductase inhibitors
US4760071A (en) * 1984-02-27 1988-07-26 Merck & Co., Inc. 17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors
NZ211145A (en) * 1984-02-27 1988-10-28 Merck & Co Inc 4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions
GB8505862D0 (en) * 1985-03-07 1985-04-11 Erba Farmitalia Steroidic 5alpha-reductase inhibitors
US4845104A (en) * 1986-11-20 1989-07-04 Merck & Co., Inc. Oxidized analogs of 17β-N-monosubstituted-carbamoyl-4-aza-5-α-androstan-3-ones
DE3780778T2 (de) * 1986-11-20 1993-01-14 Merck & Co Inc Topisches arzneimittel enthaltend 17-beta-methoxy-carbonyl-4-methyl-4-aza-5-alpha-androst-1-en-3-one.
US4888336A (en) * 1987-01-28 1989-12-19 Smithkline Beckman Corporation Steroid 5-alpha-reductase inhibitors
DE3888378T2 (de) * 1987-04-03 1994-09-29 Merck & Co Inc Behandlung von Prostatacarcinoma mit 17-beta-n-monosubstituierten-Carbamoyl-4-aza-5-alpha-Androst-1-en-3-onen.
US5237061A (en) * 1988-10-31 1993-08-17 Merck & Co., Inc. Methods of synthesizing benign prostatic hypertropic agents and their intermediates
HUT60280A (en) * 1989-07-07 1992-08-28 Endorecherche Inc Process for producing androgen derivatives inhibiting sexual steroidal activity, as well as pharmaceutical compositions comprising same
CA2023157A1 (en) * 1989-08-21 1991-02-22 Gary H. Rasmusson 17 beta-acyl-4-aza-5 alpha-androst-1-ene-3-ones as 5 alpha-reductase inhibitors
US5120847A (en) * 1990-08-27 1992-06-09 Merck & Co., Inc. Process for iodinating or brominating the α-methylenic carbon of a secondary amide
IE76452B1 (en) * 1990-10-29 1997-10-22 Sankyo Co Azasteroid compounds for the treatment of prostatic hypertrophy their preparation and use
US5304562A (en) * 1991-10-09 1994-04-19 Ciba-Geigy Corporation 17β-substituted Aza-androstane derivatives

Also Published As

Publication number Publication date
ES2101073T3 (es) 1997-07-01
EP0538192B1 (de) 1997-04-23
IL103361A0 (en) 1993-03-15
EP0538192A1 (de) 1993-04-21
JPH05213989A (ja) 1993-08-24
NO923911L (no) 1993-04-13
AU657579B2 (en) 1995-03-16
MX9205792A (es) 1993-08-01
HU9203189D0 (en) 1992-12-28
GR3024013T3 (en) 1997-10-31
KR930007969A (ko) 1993-05-20
NZ244640A (en) 1994-12-22
US5378710A (en) 1995-01-03
AU2626192A (en) 1993-04-22
TW263513B (enExample) 1995-11-21
HUT62600A (en) 1993-05-28
IL103361A (en) 1997-06-10
CA2080054A1 (en) 1993-04-10
DK0538192T3 (da) 1997-05-20
NO923911D0 (no) 1992-10-08
FI924529A0 (fi) 1992-10-07
ZA927747B (en) 1993-04-13
ATE152121T1 (de) 1997-05-15
US5304562A (en) 1994-04-19
DE59208383D1 (de) 1997-05-28

Similar Documents

Publication Publication Date Title
DE69208877D1 (de) Chinuclidinderivate
FI924160A7 (fi) Benzanilidderivat
FI935726A7 (fi) Atsanorbornaanijohdannaisia
FI924159L (fi) Benzanilidderivat
NO922182D0 (no) Krystallinske oksatiolan-derivater
FI942645A0 (fi) Uusia peptidijohdannaisia
DE69119329D1 (de) Actinonin-Derivate
FI921624L (fi) Roekningsprodukter med nya omslagspapper
FI921233L (fi) Bestaemning av kenresorption med hjaelp av en peptid som frigoers naer kollagen nedbryts
DE69125099D1 (de) Indolderivate
DK666289D0 (da) Benzenderivater
FI933450L (fi) Nya steroider
FI921262L (fi) 4-aryltiazol- eller 4-arylimidazolderivat
NO924890D0 (no) Imidazopyridiner
FI923726L (fi) Sulfaterade glykosaminoglykanoidderivat
FI925763A0 (fi) Fungicida 2-imidazolin-5-on- och 2-imidazolin-5-tionderivat
FI924529A7 (fi) Nya 17b-substituerade aza-androstan-derivat
ATE144765T1 (de) Hiv-hemmende benzenacetamidderivate
FI930345L (fi) Foerfarande foer framstaellning av renat akrylamidosulfonsyramonomerderivat
ATE171449T1 (de) Oxadolderivate
FI924353L (fi) Foerfarande foer framstaellning av nya acylaler av imidazol-5-karboxylsyraderivat
FI935243L (fi) Pyridonkarboxylsyraderivat
FI932928A0 (fi) Nya bensodiazepinderivat
FI920394A7 (fi) 3-kinuklidiinijohdannaiset
MX9206710A (es) Derivados de piridinol

Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: NOVARTIS AG

FD Application lapsed