FI92400B - Method for the preparation of sodium purines - Google Patents

Method for the preparation of sodium purines

Info

Publication number
FI92400B
FI92400B FI883803A FI883803A FI92400B FI 92400 B FI92400 B FI 92400B FI 883803 A FI883803 A FI 883803A FI 883803 A FI883803 A FI 883803A FI 92400 B FI92400 B FI 92400B
Authority
FI
Finland
Prior art keywords
sodium
purines
amino
preparation
salt
Prior art date
Application number
FI883803A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI92400C (en
FI883803A (en
FI883803A0 (en
Inventor
Albrecht Christmann
Reiner Ramert
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6333981&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI92400(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of FI883803A0 publication Critical patent/FI883803A0/en
Publication of FI883803A publication Critical patent/FI883803A/en
Publication of FI92400B publication Critical patent/FI92400B/en
Application granted granted Critical
Publication of FI92400C publication Critical patent/FI92400C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

Sodium purines, in particular disodium 2-amino-1,9-dihydropurine-6- one and sodium 1,3-dihydro-7H-purine-2,6-dione, are prepared in a one-pot process on an industrial scale and in high purity and high yields by adding formic acid to a suspension comprising the corresponding 4-aminopyrimidine derivative and sodium nitrite in formamide, followed by reduction, then heating the 4-amino-5-formylaminopyrimidine derivative obtained to 140 DEG to 180 DEG C and, after the ring closure reaction is complete, converting the product by addition of sodium hydroxide solution into the corresponding sodium salt or disodium salt, which is separated off in the form of crystals.
FI883803A 1987-08-18 1988-08-17 Process for the preparation of sodium purines FI92400C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3727508 1987-08-18
DE19873727508 DE3727508A1 (en) 1987-08-18 1987-08-18 METHOD FOR PRODUCING SODIUM PURINE

Publications (4)

Publication Number Publication Date
FI883803A0 FI883803A0 (en) 1988-08-17
FI883803A FI883803A (en) 1989-02-19
FI92400B true FI92400B (en) 1994-07-29
FI92400C FI92400C (en) 1994-11-10

Family

ID=6333981

Family Applications (1)

Application Number Title Priority Date Filing Date
FI883803A FI92400C (en) 1987-08-18 1988-08-17 Process for the preparation of sodium purines

Country Status (6)

Country Link
EP (1) EP0304004B1 (en)
JP (1) JPS6468374A (en)
AT (1) ATE96796T1 (en)
DE (2) DE3727508A1 (en)
ES (1) ES2059455T3 (en)
FI (1) FI92400C (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3928365A1 (en) * 1989-08-28 1991-03-07 Huels Chemische Werke Ag METHOD FOR PRODUCING PURE GUANINE
US5215947A (en) * 1990-10-11 1993-06-01 Savoie Refractaires Refractory parts for devices for regulation or interruption of a jet of steel, made of refractory material
DE4136114C2 (en) * 1991-11-02 1995-05-24 Boehringer Ingelheim Kg Improved process for the production of guanine and its alkali metal salts
DE4410678A1 (en) * 1994-03-28 1995-10-05 Sueddeutsche Kalkstickstoff Process for the preparation of 5-formylamino-pyrimidines
DE4422587C2 (en) * 1994-06-28 2000-11-30 Sueddeutsche Kalkstickstoff Process for the production of purines
DE19857949A1 (en) 1998-12-16 2000-06-21 Degussa Process for the production of guanine under pressure
CN111646994B (en) * 2019-12-13 2023-04-18 潍坊奥通药业有限公司 Preparation method and application of 2, 4-diamino-6-hydroxy-5-formamido pyrimidine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE645713A (en) * 1963-04-01 1964-07-16
BE647302A (en) 1963-04-30 1964-08-17
JPS5855485A (en) * 1981-09-28 1983-04-01 Kohjin Co Ltd Purification of guanine

Also Published As

Publication number Publication date
ES2059455T3 (en) 1994-11-16
EP0304004B1 (en) 1993-11-03
FI92400C (en) 1994-11-10
FI883803A (en) 1989-02-19
DE3885377D1 (en) 1993-12-09
ATE96796T1 (en) 1993-11-15
DE3727508A1 (en) 1989-03-02
EP0304004A1 (en) 1989-02-22
FI883803A0 (en) 1988-08-17
JPS6468374A (en) 1989-03-14

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Legal Events

Date Code Title Description
FG Patent granted

Owner name: BOEHRINGER INGELHEIM KG

BB Publication of examined application
MM Patent lapsed
MM Patent lapsed

Owner name: BOEHRINGER INGELHEIM KG