FI886016A - Concentrated, microbubble-type ultrasound imaging agent at room temperature - Google Patents

Concentrated, microbubble-type ultrasound imaging agent at room temperature Download PDF

Info

Publication number
FI886016A
FI886016A FI886016A FI886016A FI886016A FI 886016 A FI886016 A FI 886016A FI 886016 A FI886016 A FI 886016A FI 886016 A FI886016 A FI 886016A FI 886016 A FI886016 A FI 886016A
Authority
FI
Finland
Prior art keywords
imaging agent
microbubble
concentrated
room temperature
ultrasound imaging
Prior art date
Application number
FI886016A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI93698B (en
FI93698C (en
Inventor
Kenneth J Widder
Peter J Westkaemper
Original Assignee
Molecular Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26837357&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI886016(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/139,576 external-priority patent/US4844882A/en
Application filed by Molecular Biosystems Inc filed Critical Molecular Biosystems Inc
Publication of FI886016A publication Critical patent/FI886016A/en
Publication of FI93698B publication Critical patent/FI93698B/en
Application granted granted Critical
Publication of FI93698C publication Critical patent/FI93698C/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A61B8/481—Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Acoustics & Sound (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Surgical Instruments (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

A microbubble-type ultrasonic imaging agent is provided comprising a parenterally-administerable aqueous medium containing a dispersion of microspheres predominantly of diameters less than 10 microns, wherein the microspheres consist of gas microbubbles encapsulated with water-insolubilized biocompatible material. The imaging agent is characterized by having a concentration of greater than 100 x 10<6> microspheres per milliliter, and a stability such that this concentration is maintained for over 4 weeks at a temperature of 20 to 25 DEG C. A preferred method of producing the imaging agent is also disclosed.
FI886016A 1987-12-29 1988-12-28 Concentrated, room temperature, microbubble type ultrasound imaging agent FI93698C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13957787A 1987-12-29 1987-12-29
US13957787 1987-12-29
US13957687 1987-12-29
US07/139,576 US4844882A (en) 1987-12-29 1987-12-29 Concentrated stabilized microbubble-type ultrasonic imaging agent

Publications (3)

Publication Number Publication Date
FI886016A true FI886016A (en) 1989-06-30
FI93698B FI93698B (en) 1995-02-15
FI93698C FI93698C (en) 1995-05-26

Family

ID=26837357

Family Applications (1)

Application Number Title Priority Date Filing Date
FI886016A FI93698C (en) 1987-12-29 1988-12-28 Concentrated, room temperature, microbubble type ultrasound imaging agent

Country Status (7)

Country Link
EP (1) EP0324938B2 (en)
AT (1) ATE97325T1 (en)
DE (1) DE3885730T2 (en)
DK (1) DK173528B1 (en)
FI (1) FI93698C (en)
IE (1) IE61591B1 (en)
NO (1) NO176826C (en)

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Also Published As

Publication number Publication date
NO176826C (en) 1995-06-14
ATE97325T1 (en) 1993-12-15
DE3885730D1 (en) 1993-12-23
EP0324938B1 (en) 1993-11-18
FI93698B (en) 1995-02-15
EP0324938B2 (en) 2008-02-27
NO885796D0 (en) 1988-12-28
DK721688D0 (en) 1988-12-23
IE883127L (en) 1989-06-29
EP0324938A1 (en) 1989-07-26
IE61591B1 (en) 1994-11-16
NO885796L (en) 1989-06-30
NO176826B (en) 1995-02-27
DK173528B1 (en) 2001-01-29
FI93698C (en) 1995-05-26
DK721688A (en) 1989-06-30
DE3885730T2 (en) 1994-03-10

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