FI872752A - FOERFARANDE FOER FRAMSTAELLNING AV TERT.BUTYL-ERGOLINDERIVAT. - Google Patents

FOERFARANDE FOER FRAMSTAELLNING AV TERT.BUTYL-ERGOLINDERIVAT. Download PDF

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Publication number
FI872752A
FI872752A FI872752A FI872752A FI872752A FI 872752 A FI872752 A FI 872752A FI 872752 A FI872752 A FI 872752A FI 872752 A FI872752 A FI 872752A FI 872752 A FI872752 A FI 872752A
Authority
FI
Finland
Prior art keywords
hydrogen atom
ergolinderivat
tert
butyl
group
Prior art date
Application number
FI872752A
Other languages
Finnish (fi)
Other versions
FI85702C (en
FI85702B (en
FI872752A0 (en
Inventor
Aldemio Temperilli
Enzo Brambilla
Mauro Gobbini
Maria Antonietta Cervini
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of FI872752A0 publication Critical patent/FI872752A0/en
Publication of FI872752A publication Critical patent/FI872752A/en
Application granted granted Critical
Publication of FI85702B publication Critical patent/FI85702B/en
Publication of FI85702C publication Critical patent/FI85702C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

Ergoline derivatives of general formula I <CHEM> wherein either R1 represents a hydrogen atom or a methoxy group and R2 represents a hydrogen atom or R1 and R2 taken together represent a chemical bond, and R3 represents a hydrogen atom, an unsubstituted or substituted nicotinoyl group or a 1-oxo-2-cyclopenten-3-yl group; or a pharmaceutically acceptable salt thereof are active at the Central Nervous System level and useful therefore in the treatment of cerebral insufficiency and senile dementia.
FI872752A 1986-06-25 1987-06-22 Process for the preparation of tert.-butyl-ergoline derivatives FI85702C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8615471 1986-06-25
GB868615471A GB8615471D0 (en) 1986-06-25 1986-06-25 T-butyl ergoline derivatives

Publications (4)

Publication Number Publication Date
FI872752A0 FI872752A0 (en) 1987-06-22
FI872752A true FI872752A (en) 1987-12-26
FI85702B FI85702B (en) 1992-02-14
FI85702C FI85702C (en) 1992-05-25

Family

ID=10600059

Family Applications (1)

Application Number Title Priority Date Filing Date
FI872752A FI85702C (en) 1986-06-25 1987-06-22 Process for the preparation of tert.-butyl-ergoline derivatives

Country Status (20)

Country Link
US (2) US4843073A (en)
EP (1) EP0251652B1 (en)
JP (1) JPH0745498B2 (en)
KR (1) KR950008970B1 (en)
AT (1) ATE76407T1 (en)
AU (1) AU597672B2 (en)
CA (1) CA1339533C (en)
DE (1) DE3779190D1 (en)
DK (1) DK170099B1 (en)
ES (1) ES2042567T3 (en)
FI (1) FI85702C (en)
GB (1) GB8615471D0 (en)
GR (1) GR3005115T3 (en)
HU (1) HU196201B (en)
IE (1) IE61319B1 (en)
IL (1) IL82946A (en)
NZ (1) NZ220543A (en)
PT (1) PT85152B (en)
SU (1) SU1547708A3 (en)
ZA (1) ZA874569B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61245164A (en) * 1985-04-23 1986-10-31 Seiko Instr & Electronics Ltd Pattern correcting device
HU193782B (en) * 1985-06-21 1987-11-30 Richter Gedeon Vegyeszet Process for producing 2-halogeno-nicergoline derivatives and acid additional salts thereof
US6060483A (en) * 1996-06-27 2000-05-09 Pharmacia & Upjohn S.P.A. Antineurodegenerative ergoline derivatives
WO2014195849A2 (en) * 2013-06-03 2014-12-11 Mahesh Kandula Compositions and methods for the treatment of cerebrovascular diseases

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3228945A (en) * 1966-01-11 Methyl and i,g-dimethyl-b-(a-hydroxy- alkyl)-ergoline i derivatives
US3228941A (en) * 1966-01-11 Methyl and i,g-dimethyl-ergoline i derivatives
US3228942A (en) * 1966-01-11 Methyl and i,g-dimeti-iyl ergoline i compounds
DE203721C (en) * 1908-05-05
US3232942A (en) * 1964-06-02 1966-02-01 Sandoz Ltd 1-substituted (+)-lysergol
US3879554A (en) * 1970-03-20 1975-04-22 Farmaceutici Italia Use of 1,6-dimethyl-8-{62 -(5-bromonicotinoyloxymethyl)-10 {60 -methoxyergoline in treating cerebral and peripheral metabolic vascular disorders
USRE30218E (en) * 1974-12-06 1980-02-19 Eli Lilly And Company 8,8-Disubstituted-6-methylergolines and related compounds
US3959288A (en) * 1974-12-13 1976-05-25 Eli Lilly And Company 8-Oxymethylergolines and process therefor
US4199579A (en) * 1975-03-14 1980-04-22 Siphar S. A. Carbamates of 2-haloergolines and 2-haloergolenes and process for the preparation thereof
DE2656344A1 (en) * 1975-12-23 1977-07-07 Sandoz Ag ERGOLIN DERIVATIVES, THEIR USE AND MANUFACTURING
IT1192260B (en) * 1977-07-05 1988-03-31 Simes ERGOLINE-2-THIOETHERS AND THEIR SULPHOXIDES DERIVATIVES
GB2056437A (en) * 1979-08-07 1981-03-18 Erba Farmitalia Secoergoline derivatives
US4382940A (en) * 1979-12-06 1983-05-10 Farmitalia Carlo Erba S.P.A. Ercoline derivatives and therapeutic compositions having CNS affecting activity
DE3403067A1 (en) * 1984-01-30 1985-08-14 Eckart Prof. Dr. 6500 Mainz Eich Ergoline derivatives, process for their preparation, medicaments containing them and their use
IT1213206B (en) * 1984-08-07 1989-12-14 Inverni Della Beffa Spa PROCEDURE FOR THE PREPARATION OF LYSERGOL DERIVATIVES.
GB8612366D0 (en) * 1986-05-21 1986-06-25 Erba Farmitalia Ergoline esters
AU7914587A (en) * 1987-08-24 1989-03-31 Molecular Control Corporation Liquid crystal micelles, display, having concentric spheres

Also Published As

Publication number Publication date
FI85702C (en) 1992-05-25
DK322587A (en) 1987-12-26
EP0251652A2 (en) 1988-01-07
IL82946A (en) 1991-04-15
PT85152A (en) 1987-07-01
GR3005115T3 (en) 1993-05-24
KR880000429A (en) 1988-03-25
DK170099B1 (en) 1995-05-22
DE3779190D1 (en) 1992-06-25
HUT44543A (en) 1988-03-28
US4843073A (en) 1989-06-27
ES2042567T3 (en) 1993-12-16
JPH0745498B2 (en) 1995-05-17
AU7463287A (en) 1988-01-07
ATE76407T1 (en) 1992-06-15
PT85152B (en) 1990-03-30
KR950008970B1 (en) 1995-08-10
DK322587D0 (en) 1987-06-24
EP0251652A3 (en) 1989-04-05
JPS6322577A (en) 1988-01-30
FI85702B (en) 1992-02-14
CA1339533C (en) 1997-11-11
IE871652L (en) 1987-12-25
AU597672B2 (en) 1990-06-07
IL82946A0 (en) 1987-12-20
ZA874569B (en) 1988-02-24
IE61319B1 (en) 1994-11-02
EP0251652B1 (en) 1992-05-20
NZ220543A (en) 1989-06-28
US5079364A (en) 1992-01-07
FI872752A0 (en) 1987-06-22
GB8615471D0 (en) 1986-07-30
HU196201B (en) 1988-10-28
SU1547708A3 (en) 1990-02-28

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Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: FARMITALIA CARLO ERBA S.P.A