FI823860L - 3-(1-substituerade-4-piperidyl)-1,2-bensisoxazoler, en process foer framstaellning daerav, en farmaceutisk komposition innehaollande dessa och deras anvaendning som laekemedel - Google Patents

3-(1-substituerade-4-piperidyl)-1,2-bensisoxazoler, en process foer framstaellning daerav, en farmaceutisk komposition innehaollande dessa och deras anvaendning som laekemedel

Info

Publication number
FI823860L
FI823860L FI823860A FI823860A FI823860L FI 823860 L FI823860 L FI 823860L FI 823860 A FI823860 A FI 823860A FI 823860 A FI823860 A FI 823860A FI 823860 L FI823860 L FI 823860L
Authority
FI
Finland
Prior art keywords
piperidyl
benzenoxoxasoler
substituerade
pharmaceutical composition
och deras
Prior art date
Application number
FI823860A
Other languages
English (en)
Finnish (fi)
Other versions
FI823860A0 (fi
FI823860A7 (fi
Inventor
Joseph Thomas Strupczewski
Richard Charles Allen
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of FI823860A0 publication Critical patent/FI823860A0/fi
Publication of FI823860L publication Critical patent/FI823860L/fi
Publication of FI823860A7 publication Critical patent/FI823860A7/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/35—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/35—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction
    • C07C17/354—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction by hydrogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
FI823860A 1981-11-12 1982-11-10 3-(1-substituoituja 4-piperidyyli)-1,2- bentsisoksatsoleja, menetelmä niiden valmistamiseksi, farmaseuttinen yyhdistelmä, joka sisältää näit ä ja niiden käyttö lääkeaineina. FI823860A7 (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/319,872 US4352811A (en) 1981-11-12 1981-11-12 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles

Publications (3)

Publication Number Publication Date
FI823860A0 FI823860A0 (fi) 1982-11-10
FI823860L true FI823860L (fi) 1983-05-13
FI823860A7 FI823860A7 (fi) 1983-05-13

Family

ID=23243961

Family Applications (1)

Application Number Title Priority Date Filing Date
FI823860A FI823860A7 (fi) 1981-11-12 1982-11-10 3-(1-substituoituja 4-piperidyyli)-1,2- bentsisoksatsoleja, menetelmä niiden valmistamiseksi, farmaseuttinen yyhdistelmä, joka sisältää näit ä ja niiden käyttö lääkeaineina.

Country Status (17)

Country Link
US (1) US4352811A (h)
EP (1) EP0079564B1 (h)
JP (1) JPS5890583A (h)
AT (1) ATE18669T1 (h)
AU (1) AU556307B2 (h)
CA (1) CA1196334A (h)
DE (1) DE3270015D1 (h)
DK (1) DK503082A (h)
ES (5) ES8405396A1 (h)
FI (1) FI823860A7 (h)
GR (1) GR78402B (h)
HU (1) HU191366B (h)
IL (1) IL67235A (h)
NO (1) NO823775L (h)
NZ (1) NZ202457A (h)
PT (1) PT75848A (h)
ZA (1) ZA828278B (h)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4355037A (en) * 1981-11-12 1982-10-19 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidyl)-1,2-benzisoxales
US4352811A (en) * 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
US4469868A (en) * 1982-05-24 1984-09-04 Warner-Lambert Company Alkylimidazo[1,2-c]pyrazolo[3,4-e]pyrimidines
US4469869A (en) * 1982-08-11 1984-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(4-Piperidinium)-1,2-benzisoxazoles
US4458076A (en) * 1983-05-31 1984-07-03 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidinyl)-1,2-benzisothiazoles
US4524074A (en) * 1983-05-31 1985-06-18 Hoechst-Roussel Pharmaceuticals Inc. 3-(4-Piperidinyl)-1,2-benzisothiazoles
US4528292A (en) * 1984-04-23 1985-07-09 Hoechst-Roussel Pharmaceuticals Inc. Antihypertensive 1,2-benzisothiazole piperidines
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
CA1335289C (en) * 1987-10-26 1995-04-18 Fujio Antoku Piperidinyl benzisoxazole derivatives, their production and pharmaceutical use
FR2654104B1 (fr) * 1989-11-07 1992-01-03 Adir Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
FR2671350A1 (fr) * 1991-01-08 1992-07-10 Adir Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant.
US5147881A (en) * 1990-11-14 1992-09-15 Pfizer Inc 4-(1,2-benzisoxazolyl)piperidine antipsychotic agents
US5532240A (en) * 1991-12-26 1996-07-02 Yoshitomi Pharmaceutical Industries, Ltd. Condensed thiophene compound and pharmaceutical use thereof
TW376319B (en) * 1993-04-28 1999-12-11 Janssen Pharmaceutica Nv Pharmaceutical composition containing risperidone pamoate and having a long acting activity for treating psychoses induced by the release of dopamine
JP3645906B2 (ja) * 1993-11-19 2005-05-11 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ マイクロカプセル封入された３−ピペリジニル−置換１，２−ベンズイソオキサゾール類及び１，２−ベンズイソチアゾール類
ES2074966B1 (es) * 1994-02-11 1996-06-16 Vita Invest Sa Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-benzo(d)isoxazol-3-il)piperidin-1-il)-etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido-(1,2-a)pirimidin-4-ona.
FR2749304B1 (fr) * 1996-06-04 1998-06-26 Adir Nouveaux derives du 3-(piperid-4-yl)1,2-benzisoxazole et du 3-(piperazin-4-yl)1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
JP4627882B2 (ja) * 1998-02-09 2011-02-09 デユフアー・インターナシヨナル・リサーチ・ベー・ブイ Ｄ４−アンタゴニスト活性を有するベンズイソキサゾール誘導体
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
WO2005041937A2 (en) 2003-10-23 2005-05-12 Otsuka Pharmaceutical Co., Ltd. Controlled release sterile injectable aripiprazole formulation and method
WO2006090224A1 (en) * 2005-02-25 2006-08-31 Pfizer Japan Inc. Benzisoxazole derivatives
HUE036214T2 (hu) * 2007-07-31 2018-06-28 Otsuka Pharma Co Ltd Eljárások aripiprazol-szuszpenzió és fagyasztva szárított készítmény elõállítására
HRP20110863T1 (hr) * 2007-08-21 2011-12-31 Teva Pharmaceutical Industries Ltd. Oblik produljenog oslobađanja paliperidona
CN101759693B (zh) * 2008-12-23 2011-09-14 江苏恩华药业股份有限公司 苯骈异恶唑哌啶衍生物及在制备镇痛、镇静药物中的应用
WO2016071723A1 (en) * 2014-11-03 2016-05-12 Sifavitor S.R.L. Process for the preparation of a fluspirilene intermediate
CN104829591B (zh) * 2015-04-27 2017-05-03 梯尔希（南京）药物研发有限公司 氘代匹莫齐特的制备方法
WO2024259250A2 (en) * 2023-06-16 2024-12-19 Transneural Therapeutics, Inc. 5-ht2a receptor modulators and methods of use thereof
WO2025174820A1 (en) * 2024-02-12 2025-08-21 Ohio State Innovation Foundation Heteroaryl topoisomerase inhibitors and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE633495A (h) * 1962-06-13
US3678062A (en) * 1970-09-08 1972-07-18 American Cyanamid Co Certain 4-/(indazol-3-yl)-pyridinium/compounds
JPS5545545B2 (h) * 1972-03-17 1980-11-18
US4217349A (en) * 1974-07-01 1980-08-12 Sumitomo Chemical Company, Limited Benzisoxazole derivatives
JPS51136666A (en) * 1975-05-19 1976-11-26 Dainippon Pharmaceut Co Ltd Process for preparing 3-aminoalkyl-1,2-benzisoxazole derivatives.
FR2421899A1 (fr) * 1978-01-16 1979-11-02 Roussel Uclaf Nouveaux derives du tetrahydropyridinyl-indole et leurs sels, le procede de preparation et l'application a titre de medicaments de ces nouveaux produits
US4352811A (en) * 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles

Also Published As

Publication number Publication date
FI823860A0 (fi) 1982-11-10
ES8506658A1 (es) 1985-08-01
IL67235A (en) 1987-03-31
CA1196334A (en) 1985-11-05
JPS5890583A (ja) 1983-05-30
ES8506705A1 (es) 1985-08-01
NO823775L (no) 1983-05-13
ATE18669T1 (de) 1986-04-15
ES8506657A1 (es) 1985-07-16
HU191366B (en) 1987-02-27
EP0079564B1 (en) 1986-03-19
ES529313A0 (es) 1985-07-16
ES529312A0 (es) 1985-07-01
PT75848A (en) 1982-12-01
ES517249A0 (es) 1984-06-01
US4352811A (en) 1982-10-05
DK503082A (da) 1983-05-13
NZ202457A (en) 1986-05-09
EP0079564A1 (en) 1983-05-25
ES529314A0 (es) 1985-08-01
AU9039182A (en) 1983-05-19
IL67235A0 (en) 1983-03-31
ZA828278B (en) 1983-09-28
ES8405396A1 (es) 1984-06-01
DE3270015D1 (en) 1986-04-24
FI823860A7 (fi) 1983-05-13
GR78402B (h) 1984-09-27
ES8506293A1 (es) 1985-07-01
ES529315A0 (es) 1985-08-01
AU556307B2 (en) 1986-10-30

Similar Documents

Publication Publication Date Title
FI823860L (fi) 3-(1-substituerade-4-piperidyl)-1,2-bensisoxazoler, en process foer framstaellning daerav, en farmaceutisk komposition innehaollande dessa och deras anvaendning som laekemedel
ATE7697T1 (de) Substituierte pyrazinyl-1,2,4-oxadiazol-5-one, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung.
DK164703C (da) Analogifremgangsmaade til fremstilling af kvaternaere 6,11-dihydro-dibenzo-oeb,eaa-thiepin-11-n-alkyl-norscopinethere og mellemprodukt til anvendelse ved denne fremgangsmaade
DK15589A (da) Kemiske forbindelser
IL58299A (en) Fluorine-containing 1,4-dihydropyridine derivatives,their production and their medicinal use
DE2961609D1 (en) Sila-substituted 1,4-dihydropyridine derivatives, processes for their preparation, pharmaceutical compositions and process for their preparation
DE2960357D1 (en) Substituted cyanamides, process for their preparation and their use as fungicides
SE8002831L (sv) Oxitetracyklinberedningar
FI823433L (fi) 1-/3-(6-fluor-1,2-benzisoxazol-3-yl)propyl/-4-(substituerade) piperaziner och -piperidiner, foerfarande foer deras framstaellning, dessa innehaollande farmaceutiska kompositioner och deras anvaendning som laekemedel
ES8401484A1 (es) Procedimiento para preparar 1-(3-(6-fluoro-1,2-benzisoxazol-3-il)propil)-4-fenil-4-hidroxipiperidinas.
DK585984D0 (da) 1,7-diphenyl-3-methylaza-7-cyan-8-methyl-nonan og salte deraf til anvendelse ved bekaempelse af sygdomme samt fremgangsmaade til fremstilling af saadanne nonanderivater
FI823435A0 (fi) 8-/3-(6-fluor-1,2-benzisoxazol-3-yl),propyl/-1-fenyl-1,3,8-triazaspiro/4,5/dekan-4-oner, foerfarande foer deras framstaellning, och deras anvaendning som laekemedel
DE3264543D1 (en) Cyclic sulfenamides, process for their preparation, medicines containing them and preparation of the latter

Legal Events

Date Code Title Description
FA Application withdrawn [patent]

Owner name: HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED