FI78238B - SURGICAL PURPOSE SYNTHESIS. - Google Patents
SURGICAL PURPOSE SYNTHESIS. Download PDFInfo
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- FI78238B FI78238B FI852706A FI852706A FI78238B FI 78238 B FI78238 B FI 78238B FI 852706 A FI852706 A FI 852706A FI 852706 A FI852706 A FI 852706A FI 78238 B FI78238 B FI 78238B
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- resorbable
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- osteosynthesis device
- core
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30965—Reinforcing the prosthesis by embedding particles or fibres during moulding or dipping
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/80—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/86—Pins or screws or threaded wires; nuts therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Molecular Biology (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Manufacturing & Machinery (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
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- Materials For Medical Uses (AREA)
Description
1 782381 78238
Kirurginen osteosynteesivälineSurgical osteosynthesis device
Keksinnön kohteena on patenttivaatimuksen 1 johdannossa lähemmin määritelty kirurginen osteosynteesiväline .The invention relates to a surgical osteosynthesis device as further defined in the preamble of claim 1.
5 Tarkemmin määriteltynä keksinnössä on esitetty osteo-synteesivälineet tai niiden osat, kuten levyt, ruuvit, palkit, naulat tai tapit, jotka on valmistettu kudosolosuhteissa resorboituvasta (liukenevasta) mater iaalikombinaatiosta siten, että osteosynteesiväli-10 neillä tai niiden komponenteilla on kerroksellinen komposiittirakenne.More specifically, the invention provides osteosynthesis devices or parts thereof, such as plates, screws, beams, nails, or pins, made from a combination of materials that are resorbable (soluble) under tissue conditions such that the osteosynthesis media or components thereof are layered.
Kudosolosuhteissa liukenevia materiaaleja ja niistä valmistettavia osteosynteesivälineitä on esitetty 15 useissa patenttijulkaisuissa kuten mm. patenteissa U.S. Pat. 3 463 158, U.S. Pat. 3 620 218 ja U.S. Pat. 3 739 773, joissa on esitetty polyglykolihaposta valmistetut ydinnaulat, osteosynteesilevyt, ruuvit sekä ontot sylinterit. Patentissa G.B. Pat. 1 034 123 on 20 esitetty poly-fl-hydroksivoihaposta ja poly-fl-hydrok-sipropionihaposta valmistetut osteosynteesivälineet. Patentissa U.S. Pat. 4 052 988 on esitetty poly-p-dioksanonista valmistetut kirurgiset välineet. Patentissa U.S. Pat. 4 279 249 on esitetty komposiittiset 25 kirurgiset välineet, jotka koostuvat polyglykolihaposta valmistetuista lujiterakenteista, jotka on sijoitettu matriisiin, joka koostuu polylaktidista tai sen kopolymeerista, joka sisältää ainakin 90% yksiköistään maitohappoyksikköjä.Tissue-soluble materials and osteosynthesis devices made therefrom have been disclosed in several patent publications, e.g. U.S. Patents Pat. 3,463,158, U.S. Pat. Pat. 3,620,218 and U.S. Pat. Pat. 3,739,773, which disclose polyglycolic acid core nails, osteosynthesis plates, screws, and hollow cylinders. In G.B. Pat. 1,034,123 discloses osteosynthesis devices made of poly-β-hydroxybutyric acid and poly-β-hydroxypropionic acid. U.S. Pat. Pat. 4,052,988 discloses surgical instruments made of poly-p-dioxanone. U.S. Pat. Pat. No. 4,279,249 discloses composite surgical instruments consisting of reinforcing structures made of polyglycolic acid housed in a matrix consisting of polylactide or a copolymer thereof containing at least 90% of its units of lactic acid units.
Resorboituvien materiaalien kovuudet ja jäykkyydet vaihtelevat laajalla alueella. Esim. polyglykolidit, 30 2 78238 polylaktidit ja polyhydroksivoihappo ovat suhteellisen jäykkiä materiaaleja ja siten myös loviherkkiä ja murtuvat taivutuksessa suhteellisen helposti (taivutuslujuudet 40-60 MPa). Esim. poly-p-dioksanoni ja 5 monet sen johdannaiset taas ovat pehmeitä, taipuisia (elastisia) ja sitkeitä materiaaleja, jotka eivät usein murru lainkaan normaalissa taivutuskokeessa.The hardnesses and stiffnesses of the resorbable materials vary over a wide range. For example, polyglycolides, polylactides and polyhydroxybutyric acid are relatively rigid materials and thus also notch sensitive and break relatively easily in bending (bending strengths 40-60 MPa). For example, poly-p-dioxanone and many of its derivatives, on the other hand, are soft, flexible (elastic) and tough materials that often do not break at all in a normal bending test.
Kirurgisilta osteosynteesivälineiltä vaaditaan käyt-10 töolosuhteissa sekä jäykkyyttä että sitkeyttä. Tässä keksinnössä on esitetty kirurgiset osteosynteesiväli-neet, jotka ovat kolmiulotteisia kappaleita, kuten levyjä, ruuveja, palkkeja, nauloja tai tappeja, joille on tyypillistä kerroksellinen komposiittirakenne, 15 joka muodostuu eri jäykkyyden omaavista resorboitu-vista materiaalikerroksista siten, että komposiitti-kappaleen pintakerros muodostuu taipuisasta, joustavasta resorboituvasta polymeerisestä materiaalista ja sen alainen kerros muodostuu selvästi jäykemmästä re-20 sorboituvasta materiaalista, jonka ydin voi taas olla joustava rakenteeltaan. Keksinnön mukaisia komposiittirakenteita hyväksikäyttäen voidaan kombinoida edullisesti taipuisien ja jäykkien resorboituvien polymeerien kirurgisten sovellutusten kannalta hyviä omi-25 naisuuksia sekä eliminoida yksittäisten materiaalien epäedullisia mekaanisia ominaisuuksia valmistettaessa makroskooppisia kirurgisia kappaleita, joita käytetään luunmurtumien ja sijoiltaanmenojen ym. kudosvaurioiden hoitoon.Surgical devices for osteosynthesis require both rigidity and toughness under operating conditions. The present invention provides surgical osteosynthesis devices that are three-dimensional bodies, such as plates, screws, beams, nails, or pins, characterized by a layered composite structure consisting of resorbable layers of material having different stiffness so that the composite , a flexible resorbable polymeric material and the underlying layer consists of a clearly stiffer re-20 sorbable material, the core of which may again be flexible in structure. Utilizing the composite structures of the invention, it is possible to advantageously combine the good properties of flexible and rigid resorbable polymers for surgical applications and to eliminate the disadvantageous mechanical properties of individual materials in the manufacture of macroscopic surgical articles for the treatment of fractures and dislocations.
3030
Edellä esitettyjen tarkoitusten saavuttamiseksi ja tunnetun tekniikan epäkohtien poistamiseksi ja vähentämiseksi keksinnön mukaiselle välineelle on annettu ne pääasialliset tunnusmerkit, jotka ilmenevät 35 patenttivaatimuksen 1 tunnusmerkkiosasta.In order to achieve the above objects and to eliminate and reduce the drawbacks of the prior art, the device according to the invention is given the main features which appear from the feature part of claim 1.
3 78238 Käytettäessä resorboituvassa, makroskooppisessa kirurgisessa välineessä keksinnön mukaista komposiittirakennetta pienentää joustava ja taipuisa pintakerros kappaleen loviherkkyyttä ja parantaa siten komposiit-5 tikappaleen sitkeyttä. Toisaalta jäykkä kerros antaa makroskooppiselle kappaleelle sovellutusten kannalta tarvittavan taivutusjäykkyyden. Taivutusjäykkyyden ja samalla vetolujuuden kannalta on erityisen edullinen suoritusmuoto sellainen komposiittikappale, jossa 10 myös jäykän kerroksen ydin on joustava ja taipuisa. Tällöin jäykkä resorboituva materiaali muodostaa putkimaisen rakenteen, joka on edullinen taivutusjäykkyyden kannalta ja toisaalta joustava ja taipuisa ydin lisää kappaleen vetolujuutta.3,78238 When used in a resorbable macroscopic surgical instrument, the composite structure of the invention reduces the notch sensitivity of the body with a flexible and pliable surface layer and thus improves the toughness of the composite body. On the other hand, the rigid layer gives the macroscopic body the bending stiffness required for applications. From the point of view of bending stiffness and at the same time tensile strength, a particularly preferred embodiment is such a composite body in which the core of the rigid layer is also flexible and pliable. In this case, the rigid resorbable material forms a tubular structure which is advantageous in terms of bending stiffness and, on the other hand, the flexible and pliable core increases the tensile strength of the body.
1515
Keksinnön mukaisissa komposiittikappaleissa voidaan lisäksi käyttää eri kerroksissa biostabiileja ja/tai resorboituvia kuituja lujitteena tai soveltaa eri kerroksissa kuulutusjulkaisussa FI 75493 esitettyä 20 ns. itselujitusperiaatetta.In the composite bodies according to the invention, biostable and / or resorbable fibers can also be used as reinforcements in different layers, or the 20 ns described in the publication publication FI 75493 can be applied in different layers. itselujitusperiaatetta.
Keksintöä ja sen toimivuutta on havainnollistettu seuraavien kuvien 1 a-b avulla.The invention and its functionality are illustrated by the following Figures 1a-b.
25 Kuvassa la on esitetty eräät keksinnön mukaiset kerrokselliset komposiittikappaleet. Kyseessä on poikkileikkaus sylinterimäisestä ja suorakaiteen muotoisesta osteosynteesivälineestä tai niiden osasta kuten levystä, ydinnaulasta tai osteosynteesipalkista 30 (FI-69402), joka muodostuu joustavasta ja taipuisasta resorboituvasta materiaalista valmistetusta pintakerroksesta 1 sekä jäykästä resorboituvasta materiaalista valmistetusta sisäosasta 2. Pintakerros ja/tai sisäosa voi lisäksi sisältää biostabiileja ja/tai re-35 sorboituvia lujitekuituja tai pintakerros ja/tai 4 78238 sisäosa voi olla valmistettu itselujitusperiaatteella (esim. sintraamalla tai osittain sulattamalla kuitumaisesta materiaalista). Kuva Ib esittää poikkileikkausta sylinterimäisestä ja suorakaiteen muotoisesta 5 resorboituvasta osteosynteesivälineestä tai sen komponentista, joissa joustavan ja taipuisan resorboi-tuvan pintaosan 1 sekä jäykän resorboituvan sisäosan 2 lisäksi on joustava ja taipuisa ydin 3. Myös suoritusmuodon Ib komposiittikappaleen eri kerrokset voi-10 vat olla lujitettuja biostabiileilla ja/tai resorboi-tuvilla kuiduilla.Figure 1a shows some layered composite bodies according to the invention. This is a cross-section of a cylindrical and rectangular osteosynthesis device or a part thereof such as a plate, a core nail or an osteosynthesis beam 30 (FI-69402) consisting of a flexible and flexible resorbable material. biostable and / or re-35 sorbable reinforcing fibers or the surface layer and / or the inner part of 4,78238 may be made on a self-reinforcing principle (e.g. by sintering or partially melting from a fibrous material). Figure Ib shows a cross-section of a cylindrical and rectangular resorbable osteosynthesis device 5 or a component thereof, in which, in addition to the flexible and pliable resorbable surface part 1 and the rigid resorbable inner part 2, the flexible composite body 10 also has and / or resorbable fibers.
Kirurgisiin tarkoituksiin sopivia joustavia polymeerejä keksinnön mukaisten osteosynteesivälineiden pin-15 takerrokseksi 1 sekä ytimeksi 3 ovat esim. poly-p-dioksanoni ja sen johdannaiset ja yleensäkin polymeerit, jotka on valmistettu monomeerista: / °\ 20 R-CH C=0 I I , R-C-R HC-R' (missä R ja R' voivat olla vety, metyyli- tai etyyli-25 ryhmä). Edelleen tähän tarkoitukseen soveltuvat pit-käketjuisia molekyylinosia sisältävät polyesteriami-dit (PEA), jotka ovat diamiinin, hydroksihapon ja di-hapon kopolymeereja. PEA polymeereistä (U.S. Pat. 4 343 931) sopivat keksinnön mukaisiin osteosynteesi-30 välineisiin esim. seuraavan toistuvan kemiallisen rakenteen omaavat polymeerit: 5 78238 O 0 0 0 it il n κ -0-CH2-C-NH-(CH2)12-NH-C-CH2-0-C-(CH2)-C- (Rakennekaava I) 5 missä x on esim. 11-14, jolloin polymeerien sulamispisteet vaihtelevat alueella 80-100°C.Flexible polymers suitable for surgical purposes as pin 1 of the pin-15 and core 3 of the osteosynthesis devices according to the invention are, for example, poly-p-dioxanone and its derivatives and, in general, polymers made from the monomer: R-CH C = O II, RCR HC -R '(where R and R' may be hydrogen, methyl or ethyl). Further suitable for this purpose are long chain molecular weight polyester amides (PEA) which are copolymers of diamine, hydroxy acid and diacid. Among the PEA polymers (U.S. Pat. 4,343,931), polymers having the following repetitive chemical structure are suitable for the osteosynthesis devices according to the invention, for example: 5 78238 0 0 0 NH-C-CH 2 -O-C- (CH 2) -C- (Structural Formula I) 5 wherein x is e.g. 11-14, wherein the melting points of the polymers range from 80-100 ° C.
Jäykäksi sisäosaksi 2 sopivia materiaaleja ovat esim. 10 polyglykolidit, polylaktidit, glykolidi/laktidi kopo-lymeerit sekä poly-B-hydroksivoihappo.Suitable materials for the rigid inner part 2 are, for example, polyglycolides, polylactides, glycolide / lactide copolymers and poly-β-hydroxybutyric acid.
Keksintöä on havainnollistettu seuraavien esimerkkien avulla.The invention is illustrated by the following examples.
15 ESIMERKKI 115 EXAMPLE 1
Polyglykolihapon sulatteesta (sisäinen viskositeetti | n| =1.2 0.5% heksafluoroisopropanoliliuoksessa (TPolyglycolic acid melt (intrinsic viscosity | n | = 1.2 in 0.5% hexafluoroisopropanol solution (T
20 = 25°C), sulamispiste Tm = 224°C) valmistettiin ruis kupuristuksella sylinterimaisiä sauvoja (pituus 70 mm, halkaisija 4 mm). Sauvat pinnoitettiin 0.25 mm paksuisella kerroksella poly-p-dioksanonia (sisäinen viskositeetti | n| = 0.80 0.1% tetrakloorietaani- 25 liuoksessa (T = 25°C), sulamispiste T = 110°C) ruis- m kupuristusmuotissa, jolloin saatiin paksuudeltaan 4.5 mm sylinterimaisiä resorboituvia kerroksellisia kom-posiittisauvoj a.20 = 25 ° C), melting point Tm = 224 ° C) were prepared by injection molding cylindrical rods (length 70 mm, diameter 4 mm). The rods were coated with a 0.25 mm thick layer of poly-p-dioxanone (intrinsic viscosity | n | = 0.80 in 0.1% tetrachloroethane solution (T = 25 ° C, melting point T = 110 ° C) in an injection mold to give a thickness of 4.5 mm. cylindrical resorbable layered composite rods a.
30 ESIMERKKI 230 EXAMPLE 2
Polyglykolihaposta valmistetuista kirurgisista haava-ompeleista (kauppanimi Dexon, koko 2-0) valmistettiin ahtopuristimessa sintraamalla 220°C lämpötilassa it-35 selujitettuja sylinterimäisiä sauvoja (pituus 70 mm.Surgical wound sutures made of polyglycolic acid (trade name Dexon, size 2-0) were prepared in a compression press by sintering cylindrical rods (length 70 mm) reinforced with it-35 at 220 ° C.
6 78238 halkaisija 4 mm). Sauvat pinnoitettiin ruiskupuris-tusmenetelmää hyväksikäyttäen 0.25 mm paksuisella kerroksella poly-p-dioksanonia (| n| = 0.8, Tm = 110°C), jolloin saatiin paksuudeltaan 4.5 mm sylin-5 terimäisiä resorboituvia komposiittisauvoja.6 78238 diameter 4 mm). The rods were spray-coated using a 0.25 mm thick layer of poly-p-dioxanone (| n | = 0.8, Tm = 110 ° C) to give 4.5 mm thick resin-absorbable composite rods with a thickness of 4.5 mm.
ESIMERKKI 3EXAMPLE 3
Polyglykolihapon sulatteesta (| η| = 1.2, Tm = 224°C) 10 valmistettiin ruiskupuristuksella putkimaisia kappaleita (pituus 70 mm, seinämän ulkohalkaisija 4 mm, sisähalkaisija 1.5 mm). Putkien sisäkanavaan ja ulkopintaan valettiin ruiskupuristustekniikalla poly-p-dioksanonia siten, että saatiin paksuudeltaan 4.5 mm 15 sylinterimäisiä resorboituvia kerroksellisia komposiittisauvoja (vrt. kuva Ib).From the melt of polyglycolic acid (| η | = 1.2, Tm = 224 ° C) 10 tubular bodies (length 70 mm, outer wall diameter 4 mm, inner diameter 1.5 mm) were prepared by injection molding. Poly-p-dioxanone was injection molded into the inner channel and the outer surface of the tubes to obtain cylindrical resorbable layered composite rods with a thickness of 4.5 mm (cf. Fig. Ib).
ESIMERKKI 4 20 Polyglykolidi/laktidi kopolymeerista valmistetuista haavaompeleista, polylactin 910 (kauppanimi Vicryl) valmistettiin ahtopuristimessa sintraamalla 180°C lämpötilassa putkimaisia itselujitettuja resorboituvia kappaleita (pituus 70 mm, seinämän ulkohalkaisija 25 4 mm, sisähalkaisija 1.5 mm). Putkien sisäkanavaan ja ulkopintaan valettiin ruiskupuristustekniikalla poly-p-dioksanonia siten, että saatiin paksuudeltaan 4.5 mm sylinterimäisiä resorboituvia kerroksellisia komposiittisauvoja.EXAMPLE 4 From wound sutures made of a polyglycolide / lactide copolymer, polylactin 910 (trade name Vicryl) was prepared in a compression press by sintering at 180 ° C tubular self-reinforced resorbable bodies (length 70 mm, outer wall diameter 25 mm, inner diameter 25 mm). Poly-p-dioxanone was injection molded into the inner channel and outer surface of the tubes to obtain 4.5 mm thick cylindrical resorbable layered composite rods.
30 ESIMERKKI 530 EXAMPLE 5
Polyglykolidi|laktidi kopolymeerista valmistetuista haavaompeleista, polylactin 910 (kauppanimi Vicryl) 35 valmistettiin ahtopuristimessa sintraamalla 180°CFrom wound sutures made of polyglycolide / lactide copolymer, polylactin 910 (trade name Vicryl) 35 was prepared by compression molding at 180 ° C
1 78238 lämpötilassa putkimaisia itselujitettuja resorboitu-via kappaleita (pituus 70 mm, seinämän ulkohalkaisija 4 mm, sisähalkaisija 1.5 mm). Putkien sisäkanavaan ja ulkopintaan valettiin ruiskupuristustekniikalla poly-5 esteriamidia (rakennekaava I, missä x = 12) siten, että saatiin paksuudeltaan 4.5 mm sylinterimäisiä re-sorboituvia kerroksellisia komposiittisauvoja.1 78238 tubular self-reinforced resorbable bodies (length 70 mm, outer wall diameter 4 mm, inner diameter 1.5 mm). Poly-5 esteramide (structural formula I, where x = 12) was injection molded into the inner channel and the outer surface of the tubes to obtain 4.5 mm thick cylindrical resorbable layered composite rods.
Claims (7)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI852706A FI78238C (en) | 1985-07-09 | 1985-07-09 | SURGICAL PURPOSE SYNTHESIS. |
AU61356/86A AU6135686A (en) | 1985-07-09 | 1986-07-02 | Surgical resorbable devices with layered composite structure |
PCT/FI1986/000071 WO1987000059A1 (en) | 1985-07-09 | 1986-07-02 | Surgical resorbable devices with layered composite structure |
EP86904187A EP0239577A1 (en) | 1985-07-09 | 1986-07-02 | Surgical resorbable devices with layered composite structure |
CA000512961A CA1277602C (en) | 1985-07-09 | 1986-07-03 | Surgical devices with layered composite structure |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI852706 | 1985-07-09 | ||
FI852706A FI78238C (en) | 1985-07-09 | 1985-07-09 | SURGICAL PURPOSE SYNTHESIS. |
Publications (4)
Publication Number | Publication Date |
---|---|
FI852706A0 FI852706A0 (en) | 1985-07-09 |
FI852706L FI852706L (en) | 1987-01-10 |
FI78238B true FI78238B (en) | 1989-03-31 |
FI78238C FI78238C (en) | 1989-07-10 |
Family
ID=8521104
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI852706A FI78238C (en) | 1985-07-09 | 1985-07-09 | SURGICAL PURPOSE SYNTHESIS. |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0239577A1 (en) |
AU (1) | AU6135686A (en) |
CA (1) | CA1277602C (en) |
FI (1) | FI78238C (en) |
WO (1) | WO1987000059A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI75493C (en) * | 1985-05-08 | 1988-07-11 | Materials Consultants Oy | SJAELVARMERAT ABSORBERBART PURCHASING SYNTHESIS. |
FI80605C (en) * | 1986-11-03 | 1990-07-10 | Biocon Oy | Bone surgical biocomposite material |
FI83477C (en) * | 1987-07-10 | 1991-07-25 | Biocon Oy | Absorbent material for fixing tissues |
JPH07503869A (en) * | 1992-02-14 | 1995-04-27 | ボード・オヴ・リージェンツ,ザ・ユニヴァーシティ・オヴ・テキサス・システム | Multiphasic bioerodible implant materials or carriers and methods of manufacture and use thereof |
US6013853A (en) * | 1992-02-14 | 2000-01-11 | The University Of Texas System | Continuous release polymeric implant carrier |
US5876452A (en) * | 1992-02-14 | 1999-03-02 | Board Of Regents, University Of Texas System | Biodegradable implant |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3867190A (en) * | 1971-10-18 | 1975-02-18 | American Cyanamid Co | Reducing capillarity of polyglycolic acid sutures |
US4052988A (en) * | 1976-01-12 | 1977-10-11 | Ethicon, Inc. | Synthetic absorbable surgical devices of poly-dioxanone |
EP0013862A1 (en) * | 1979-01-26 | 1980-08-06 | Osteo Ag | Osteosynthetic plate |
US4512038A (en) * | 1979-04-27 | 1985-04-23 | University Of Medicine And Dentistry Of New Jersey | Bio-absorbable composite tissue scaffold |
CH644748A5 (en) * | 1980-06-03 | 1984-08-31 | Sulzer Ag | STRING AND / OR TAPE REPLACEMENT MATERIAL. |
US4655777A (en) * | 1983-12-19 | 1987-04-07 | Southern Research Institute | Method of producing biodegradable prosthesis and products therefrom |
-
1985
- 1985-07-09 FI FI852706A patent/FI78238C/en not_active IP Right Cessation
-
1986
- 1986-07-02 EP EP86904187A patent/EP0239577A1/en not_active Withdrawn
- 1986-07-02 WO PCT/FI1986/000071 patent/WO1987000059A1/en not_active Application Discontinuation
- 1986-07-02 AU AU61356/86A patent/AU6135686A/en not_active Abandoned
- 1986-07-03 CA CA000512961A patent/CA1277602C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1987000059A1 (en) | 1987-01-15 |
FI78238C (en) | 1989-07-10 |
AU6135686A (en) | 1987-01-30 |
FI852706L (en) | 1987-01-10 |
CA1277602C (en) | 1990-12-11 |
EP0239577A1 (en) | 1987-10-07 |
FI852706A0 (en) | 1985-07-09 |
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Legal Events
Date | Code | Title | Description |
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MM | Patent lapsed |
Owner name: BIOCON OY |