FI60108B - TILL KATJONSAMMANSAETTNINGEN PHYSIOLOGICAL OPTIMERS MINERALVATTEN - Google Patents

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--1 rft1 ANNOUNCEMENT. Λ „Λ _ W (11) UTLAGGNINGSSKRIFT 601 0 8 (45) ^ ν ^ (51) K» .ik? / «Nt.ci.3 A 23 I 2/38 FINLAND — FINLAND £ 1) Ptt« nttlh * k * mu * - Pstanttnseknlnj 792 5 82 (22) Hakamispiivl - AmBknlngadag 20.08.79 '' (23) Alkupllv · —Glltlghetadag 2U.02.78 (41) ΤμΙΙιΚ Julkbek *! - Bllvlt offvntllg 25.08.79

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Patent- och registerstyrelsen '' AmMcm uthtd oeh uti. * Krtft «n pubiic« r »d 31.08.8l (32) (33) (31) Requested« tuolk * ui — Bvgird prloritet (71) Suomen Lääketehdas Oy Salco, Sahaajankatu U9 , 008l0 Helsinki 8l,

Suomi-Finland (FI) (72) Heikki Karppanen, Oulu, Eero Bergqvist, Helsinki, Finland-Finland (FI) (7 * 0 Oy Kolster Ab (5 * 0 Mineral water with physiologically optimized cation composition -Accounting physiological optimization of mineral waters (62) By sharing separated from application 780627 (advertisement publication 60107) -Avdelad frln ansökan 780627 (utläggningsskrift 60107)

The invention relates to mineral water with a physiologically optimized cationic composition.

The balance of the body’s electrolyte system is based on compensating for the constant loss of its various ingredients through oral supplementation, mainly nutrition. Since nutrition has been predominantly tradition-based, many of the key interactions between nutrition and the needs of the body have so far not been much addressed. In today’s industrialized world, dietary sodium, potassium, magnesium, and calcium levels are in sharp proportion to each other. In the daily diet, sodium and calcium often exceed the optimal values many times over, while the amounts of potassium and magnesium often remain substantially lower than the recommendations.

Mainly due to changes in dietary habits and production methods, the cationic balance of food has sharply deviated from its optimal ratios and daily minimum amounts in recent decades by 2,60,108:

Sodium 10-60 mmol / day

Potassium 50 - 100

Magnesium 12-40 ""

Calcium 20 - 35 ""

In the measurements, the so-called food produced by the industrialized world contains large amounts of certain cations and, on the other hand, very small amounts of other cations.

The average resident of an industrialized country has been measured to receive cations as follows:

Sodium 230 mmol / day up to 460 mmol / day Potassium 60 mmol / day "10" "

Magnesium 15 mmol / day 2

Calcium 60 mmol / day "210" "(Carp: Adv. Cardiol., Vol. 25 pp. 9-24, 1978; Meneely: The American Journal of Cardiology, Vol. 38, pp. 768-785, 1976).

In the case of sodium and calcium, distortion is usually caused by the excessive use of table salt and dairy products, while magnesium and potassium have been sharply reduced as a result of measures to clean, prepare and preserve cereals and other nutrients. In recent years, the medical literature has reported a number of disorders due to disproportionate electrolyte coagulation in the diet, which, if prolonged, lead to pathological changes in many functions of the body. Hypertension and degenerative vascular and cardiovascular diseases have been the focus of attention in this context (Karppanen: Adv. Cardiol., Vol.

25, pp. 9-24, 1978; Masironi: Bull. WHO, Vol. 40, pp. 305-312, 1969; Meneely: The American Journal of Cardiology, Vol. 38, pp. 768-785, 1976; Schroeder: Medical Clinics of North America, Vol. 58, pp. 381-396, no. 2, 1974; WHO Chronicle, Vol. 27 pp. 534-538, 1973). Despite the alarming situation, no measures have been taken so far in the field of normal nutrition to optimize the intake of electrolytes.

From the field of heart disease treatment come some limited attempts to eliminate sodium overload by replacing part of the dietary salt requirement, most commonly with potassium or ammonium-containing substitutes. Similarly, potassium tablets have been used to balance the excess sodium produced by some drugs used in the treatment of hypertension, such as thiazides. What is illustrative of the methods used, however, is that they target disease states and only compensate for excess sodium cations without paying attention to the relationships of other cations that dynamically affect the situation. Thus, the current way of thinking does not take into account the importance of disproportionate intake of electrolytes as a cause of severe health disorders, and the current methods do not offer a substantial opportunity to eliminate the existing disproportions.

One of the main disparities in current nutrition is the excessive supply of sodium. One of the key mechanisms of sodium excess is based on the ability of sodium to increase potassium secretion in nephritis, which in turn causes potassium loss in the body. When the potassium supply, as can be seen from the tables, is often deficient, an increased mismatch within this physiologically important ion pair results. Extensive cross-country studies have found that the incidence of hypertension is strongly correlated with the disproportionate use of sodium and potassium. Normally, the diet should contain sodium and potassium in an optimal molar ratio of Na: K = 1: 1.

Calcium and magnesium concentration ratios play a key role in several electrophysiological and enzymatic reactions of the heart and nervous system. The optimal ratio of their molar concentrations in the diet has been estimated to be: Ca: Mg = 1: 1 to 2: 1. In addition, magnesium has been found to have a crucial effect in promoting potassium utilization. Even if the daily diet is rich in potassium, the body is unable to utilize it, but potassium is rapidly excreted in the presence of magnesium deficiency. The intracellular electrolyte balance requires a certain molar ratio of magnesium to potassium in the diet, which is optimally Mg: K = 1: 4. The incidence of certain heart diseases has been found to be strongly correlated with potassium deficiency, especially when magnesium intake is also deficient. If the diet is high in calcium and low in magnesium, a high amount of calcium substantially reduces the absorption of magnesium. This means that as magnesium intake decreases, the biological utilization of potassium also becomes more difficult. Optimally, the diet should contain a molar molar ratio of Ca: Mg = 1: 1 to 2: 1.

601 08 4

The concentrations of sodium, potassium, calcium and magnesium in the mineral water according to the invention have been optimized to meet the needs of the body. The mineral water according to the invention is then characterized in that it contains sodium, potassium, magnesium and possibly calcium in molar ratios:

Na: K = 1: 1 4 K: Mg = 3: 1 - 4: 1 Ca: Mg = 1: 1 - 2: 1 and that their concentrations are in the range: sodium 2-40, preferably 16 mmol / liter, potassium 2 -40, preferably 16 mmol / liter, magnesium 0.66-13.3, preferably 4 mmol / liter and optionally calcium 1.25-20, preferably 4-8 mmol / liter.

Such a balanced product contributes to alleviating the imbalance that exists in cation concentrations in the daily diet.

The cations may be present in the mineral water as any physiologically acceptable compound such as chloride, bromide, iodide, sulfate, carbonate or asparagate.

Example

Previously known mineral waters have concentrations of said cations in mmol / liter in the following range:

Na K Mg Ca 6-15 0.13-2.0 0.3-1.4 0.75-0.87, The molar ratios of cations are then as follows:

Na: K = 3: 1-115: 1 K: Mg = 6.6: 1-0.1: 1 Ca: Mg = 2.9: 1 - 0.5: 1

The mineral water concentrations according to the invention have cation concentrations in mmol / liter, for example the following:

Sodium Potassium Magnesium Calcium (if applicable) 1. 22 0.66 1.25 2. (preferred values 16 16 4 4-8) 3. 28 28 7-9 7-14 4. 40 40 10-13 10-20 These concentrations correspond to the molar ratios of cations in the mineral water according to the invention.