FI47354C - Process for the preparation of 6,7-methylene-20-spirox-4-en-3-ones, which are antagonists to aldosterone. - Google Patents

Process for the preparation of 6,7-methylene-20-spirox-4-en-3-ones, which are antagonists to aldosterone.

Info

Publication number
FI47354C
FI47354C FI690718A FI71869A FI47354C FI 47354 C FI47354 C FI 47354C FI 690718 A FI690718 A FI 690718A FI 71869 A FI71869 A FI 71869A FI 47354 C FI47354 C FI 47354C
Authority
FI
Finland
Prior art keywords
spirox
aldosterone
antagonists
methylene
ones
Prior art date
Application number
FI690718A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI47354B (en
Inventor
Arth
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI47354B publication Critical patent/FI47354B/fi
Application granted granted Critical
Publication of FI47354C publication Critical patent/FI47354C/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • E—FIXED CONSTRUCTIONS
    • E05—LOCKS; KEYS; WINDOW OR DOOR FITTINGS; SAFES
    • E05G—SAFES OR STRONG-ROOMS FOR VALUABLES; BANK PROTECTION DEVICES; SAFETY TRANSACTION PARTITIONS
    • E05G1/00—Safes or strong-rooms for valuables
    • E05G1/02—Details
    • E05G1/024—Wall or panel structure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
FI690718A 1968-03-22 1969-03-11 Process for the preparation of 6,7-methylene-20-spirox-4-en-3-ones, which are antagonists to aldosterone. FI47354C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71516068A 1968-03-22 1968-03-22

Publications (2)

Publication Number Publication Date
FI47354B FI47354B (en) 1973-07-31
FI47354C true FI47354C (en) 1973-11-12

Family

ID=24872890

Family Applications (1)

Application Number Title Priority Date Filing Date
FI690718A FI47354C (en) 1968-03-22 1969-03-11 Process for the preparation of 6,7-methylene-20-spirox-4-en-3-ones, which are antagonists to aldosterone.

Country Status (14)

Country Link
AT (1) AT297948B (en)
BE (1) BE730163A (en)
BR (1) BR6907426D0 (en)
CH (1) CH525876A (en)
DK (1) DK123353B (en)
FI (1) FI47354C (en)
FR (1) FR2004562A1 (en)
GB (1) GB1235768A (en)
IE (1) IE33205B1 (en)
IL (1) IL31769A (en)
NL (1) NL166267C (en)
NO (1) NO131175C (en)
SE (1) SE351636B (en)
YU (1) YU34303B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE792624A (en) * 1972-05-22 1973-06-12 Merck & Co Inc ALDOSTERONE INHIBITORS AND THEIR OBTAINING
DE2652761C2 (en) * 1976-11-16 1985-11-21 Schering AG, 1000 Berlin und 4709 Bergkamen 15,16-methylene-spirolactones, processes for their preparation and pharmaceuticals containing them
AT351191B (en) * 1976-12-20 1979-07-10 Hoffmann La Roche METHOD FOR PRODUCING NEW D-HOMOSTEROIDS
DE3222265A1 (en) * 1982-06-09 1983-12-15 Schering AG, 1000 Berlin und 4709 Bergkamen 6SS.7SS-METHYLENE-17 (ALPHA) -PREGN-4-EN-21.17-CARBOLACTONE, METHOD FOR THE PRODUCTION AND USE THEREOF AS A MEDICINAL PRODUCT
JPS59139400A (en) * 1983-01-31 1984-08-10 Shionogi & Co Ltd Steroid derivative with antialdosteronic activity

Also Published As

Publication number Publication date
FI47354B (en) 1973-07-31
YU34303B (en) 1979-04-30
CH525876A (en) 1972-07-31
NL166267C (en) 1981-07-15
IE33205B1 (en) 1974-04-17
DE1914507A1 (en) 1969-10-09
AT297948B (en) 1972-04-10
NL166267B (en) 1981-02-16
DK123353B (en) 1972-06-12
IL31769A (en) 1973-08-29
FR2004562A1 (en) 1969-11-28
NO131175B (en) 1975-01-06
IL31769A0 (en) 1969-05-28
BR6907426D0 (en) 1973-05-31
SE351636B (en) 1972-12-04
YU58169A (en) 1978-10-31
NO131175C (en) 1975-04-16
NL6903322A (en) 1969-09-24
BE730163A (en) 1969-09-22
GB1235768A (en) 1971-06-16
IE33205L (en) 1969-09-22

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