FI20051271A - Compounds and compositions for allosteric modulation of the GABA receptor - Google Patents

Compounds and compositions for allosteric modulation of the GABA receptor Download PDF

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Publication number
FI20051271A
FI20051271A FI20051271A FI20051271A FI20051271A FI 20051271 A FI20051271 A FI 20051271A FI 20051271 A FI20051271 A FI 20051271A FI 20051271 A FI20051271 A FI 20051271A FI 20051271 A FI20051271 A FI 20051271A
Authority
FI
Finland
Prior art keywords
compositions
compounds
gaba receptor
allosteric modulation
receptor
Prior art date
Application number
FI20051271A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI118687B (en
Inventor
Ravindra B Upasani
Haiji Xia
Derk Hogenkamp
Original Assignee
Cocensys Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26892391&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI20051271(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cocensys Inc filed Critical Cocensys Inc
Publication of FI20051271A publication Critical patent/FI20051271A/en
Application granted granted Critical
Publication of FI118687B publication Critical patent/FI118687B/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom

Abstract

Methods, compositions and compounds for modulating the GABAA receptor-chloride ionophore complex to alleviate stress, anxiety, seizures, mood disorders, PMS and PND and to induce anesthesia.
FI20051271A 1994-02-14 2005-12-09 Compounds and compositions for allosteric modulation of the GABA receptor FI118687B (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US19691994A 1994-02-14 1994-02-14
US19691994 1994-02-14
US34692794A 1994-11-23 1994-11-23
US34692794 1994-11-23
PCT/US1995/001712 WO1995021617A1 (en) 1994-02-14 1995-02-14 Androstanes and pregnanes for allosteric modulation of gaba receptor
US9501712 1995-02-14

Publications (2)

Publication Number Publication Date
FI20051271A true FI20051271A (en) 2005-12-09
FI118687B FI118687B (en) 2008-02-15

Family

ID=26892391

Family Applications (2)

Application Number Title Priority Date Filing Date
FI963174A FI118008B (en) 1994-02-14 1996-08-13 Androstanes and pregnanes for allosteric modulation of the GABA receptor
FI20051271A FI118687B (en) 1994-02-14 2005-12-09 Compounds and compositions for allosteric modulation of the GABA receptor

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI963174A FI118008B (en) 1994-02-14 1996-08-13 Androstanes and pregnanes for allosteric modulation of the GABA receptor

Country Status (18)

Country Link
EP (2) EP1038880B1 (en)
JP (1) JP4066272B2 (en)
KR (1) KR100338287B1 (en)
AT (2) ATE375993T1 (en)
AU (1) AU691905B2 (en)
BR (1) BR9506779A (en)
CA (1) CA2183231A1 (en)
DE (2) DE69518509T2 (en)
DK (2) DK0752860T3 (en)
ES (2) ES2296594T3 (en)
FI (2) FI118008B (en)
GR (1) GR3034810T3 (en)
HK (1) HK1014665A1 (en)
IL (1) IL112638A (en)
NO (1) NO308307B1 (en)
NZ (1) NZ282939A (en)
PT (2) PT752860E (en)
WO (1) WO1995021617A1 (en)

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Also Published As

Publication number Publication date
WO1995021617A1 (en) 1995-08-17
ES2296594T3 (en) 2008-05-01
DE69535623D1 (en) 2007-11-29
ES2151593T3 (en) 2001-01-01
BR9506779A (en) 1997-10-14
DE69518509D1 (en) 2000-09-28
CA2183231A1 (en) 1995-08-17
NO308307B1 (en) 2000-08-28
AU691905B2 (en) 1998-05-28
DE69518509T2 (en) 2001-04-19
FI118687B (en) 2008-02-15
ATE195654T1 (en) 2000-09-15
PT1038880E (en) 2008-01-29
GR3034810T3 (en) 2001-02-28
IL112638A (en) 2003-10-31
EP0752860A4 (en) 1998-05-06
DE69535623T2 (en) 2008-07-24
FI118008B (en) 2007-05-31
NO963355L (en) 1996-10-11
DK0752860T3 (en) 2000-11-13
ATE375993T1 (en) 2007-11-15
IL112638A0 (en) 1995-05-26
PT752860E (en) 2000-12-29
NZ282939A (en) 1998-08-26
DK1038880T3 (en) 2008-03-03
KR100338287B1 (en) 2002-11-30
EP1038880A3 (en) 2003-07-16
HK1014665A1 (en) 1999-09-30
NO963355D0 (en) 1996-08-12
FI963174A (en) 1996-09-25
AU2090195A (en) 1995-08-29
EP1038880A2 (en) 2000-09-27
EP0752860B1 (en) 2000-08-23
EP1038880B1 (en) 2007-10-17
FI963174A0 (en) 1996-08-13
JP4066272B2 (en) 2008-03-26
EP0752860A1 (en) 1997-01-15
JPH09510701A (en) 1997-10-28

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