FI20050467A - Methods for promoting growth hormone release in an animal - Google Patents

Methods for promoting growth hormone release in an animal Download PDF

Info

Publication number
FI20050467A
FI20050467A FI20050467A FI20050467A FI20050467A FI 20050467 A FI20050467 A FI 20050467A FI 20050467 A FI20050467 A FI 20050467A FI 20050467 A FI20050467 A FI 20050467A FI 20050467 A FI20050467 A FI 20050467A
Authority
FI
Finland
Prior art keywords
growth hormone
animal
methods
promoting growth
hormone release
Prior art date
Application number
FI20050467A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI120691B (en
Inventor
Cyril Y Bowers
David H Coy
Original Assignee
Univ Tulane
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Tulane filed Critical Univ Tulane
Publication of FI20050467A publication Critical patent/FI20050467A/en
Application granted granted Critical
Publication of FI120691B publication Critical patent/FI120691B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/60Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/02Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

Novel peptides of the formula A1-A2-Ala-Trp-DPhe-A5 are disclosed which promote the release of growth hormone when administered to animals. These peptides can be used therapeutically.
FI20050467A 1991-08-22 2005-05-02 Non-therapeutic method for promoting release of growth hormone in animals FI120691B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/748,350 US5663146A (en) 1991-08-22 1991-08-22 Polypeptide analogues having growth hormone releasing activity
US74835091 1991-08-22
PCT/US1992/007026 WO1993004081A1 (en) 1991-08-22 1992-08-20 Peptides having growth hormone releasing activity
US9207026 1992-08-20

Publications (2)

Publication Number Publication Date
FI20050467A true FI20050467A (en) 2005-05-02
FI120691B FI120691B (en) 2010-01-29

Family

ID=25009088

Family Applications (2)

Application Number Title Priority Date Filing Date
FI940807A FI120095B (en) 1991-08-22 1994-02-21 A process for the preparation of peptides having growth hormone releasing activity
FI20050467A FI120691B (en) 1991-08-22 2005-05-02 Non-therapeutic method for promoting release of growth hormone in animals

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI940807A FI120095B (en) 1991-08-22 1994-02-21 A process for the preparation of peptides having growth hormone releasing activity

Country Status (26)

Country Link
US (2) US5663146A (en)
EP (1) EP0605484B1 (en)
JP (1) JP3179489B2 (en)
KR (1) KR100247212B1 (en)
CN (1) CN1035256C (en)
AT (1) ATE172742T1 (en)
AU (1) AU666673B2 (en)
BG (1) BG62655B1 (en)
BR (2) BR9206398A (en)
CA (1) CA2116120C (en)
CZ (1) CZ293281B6 (en)
DE (1) DE69227462T2 (en)
DK (1) DK0605484T3 (en)
ES (1) ES2124263T3 (en)
FI (2) FI120095B (en)
HU (1) HU223664B1 (en)
IL (1) IL102848A (en)
MX (1) MX9204861A (en)
NO (1) NO314695B1 (en)
NZ (1) NZ244034A (en)
PL (1) PL169562B1 (en)
RO (1) RO112507B1 (en)
RU (1) RU2126014C1 (en)
SK (1) SK282895B6 (en)
WO (1) WO1993004081A1 (en)
ZA (1) ZA926337B (en)

Families Citing this family (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2160786A1 (en) 1993-05-14 1994-11-24 James C. Marsters, Jr. Ras farnesyl transferase inhibitors
HU221092B1 (en) * 1993-12-23 2002-08-28 Novo Nordisk As Compounds with growth hormone releasing properties
HU224345B1 (en) * 1993-12-23 2005-08-29 Novo Nordisk A/S. Peptides with growth hormone releasing properties, pharmaceutical compositions comprising thereof and their use
US5798337A (en) * 1994-11-16 1998-08-25 Genentech, Inc. Low molecular weight peptidomimetic growth hormone secretagogues
US20020111461A1 (en) * 1999-05-21 2002-08-15 Todd C. Somers Low molecular weight peptidomimetic growth hormone secretagogues
BR9608909A (en) * 1995-06-22 1999-03-02 Novo Nordisk As Compound pharmaceutical composition processes to stimulate the release of growth hormone from patuitaria and increase the speed and extent of growth of animals to increase milk or wool production of animals or for diseases and use of the compound
ATE231131T1 (en) * 1996-04-24 2003-02-15 Novo Nordisk As COMPOUNDS WITH GUARD HORMONE RELEASING PROPERTIES
EP1005484A1 (en) 1997-06-20 2000-06-07 Novo Nordisk A/S Compounds with growth hormone releasing properties
US6127341A (en) * 1997-06-20 2000-10-03 Novo Nordisk A/S Compounds with growth hormone releasing properties
ZA987383B (en) * 1997-08-19 2000-02-17 Lilly Co Eli Treatment of congestive heart failure with growth hormone secretagogues.
US6329342B1 (en) 1997-08-19 2001-12-11 Eli Lilly And Company Treatment of congestive heart failure with growth hormone secretagogues
AU766305B2 (en) 1998-01-16 2003-10-16 Novo Nordisk A/S Compounds with growth hormone releasing properties
WO1999039730A1 (en) * 1998-02-09 1999-08-12 Kaken Pharmaceutical Co., Ltd. Oral preparations containing peptides promoting the secretion of growth hormone
US6919315B1 (en) 1998-06-30 2005-07-19 Novo Nordisk A/S Compounds with growth hormone releasing properties
US6682908B1 (en) 1998-07-10 2004-01-27 Merck & Co., Inc. Mouse growth hormone secretagogue receptor
JP2002520011A (en) 1998-07-13 2002-07-09 メルク・アンド・カンパニー・インコーポレーテッド Growth hormone secretagogue-related receptors and nucleic acids
JP2002522058A (en) 1998-08-10 2002-07-23 メルク・アンド・カンパニー・インコーポレーテッド Canine growth hormone secretagogue receptor
US6468974B1 (en) 1998-08-14 2002-10-22 The Administrators Of The Tulane Educational Fund Compounds having growth hormone releasing activity
US6639076B1 (en) 1998-08-18 2003-10-28 Eli Lilly And Company Growth hormone secretagogues
US6696063B1 (en) 1998-12-30 2004-02-24 Applied Research Systems Ars Holding N.V. Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy
US7022677B1 (en) 1999-02-18 2006-04-04 Kaken Pharmaceutical Co., Ltd. Amide derivatives as growth hormone secretagogues
AU759022B2 (en) * 1999-02-18 2003-04-03 Kaken Pharmaceutical Co., Ltd. Novel amide derivatives as growth hormone secretagogues
US6828331B1 (en) * 1999-02-19 2004-12-07 Eli Lilly And Company Growth hormone secretagogues
US20040192593A1 (en) * 1999-07-26 2004-09-30 Baylor College Of Medicine Protease resistant ti-growth hormone releasing hormone
KR20020047096A (en) * 1999-07-26 2002-06-21 크로커 사무엘 에스 Super-active porcine growth hormone releasing hormone analog
JP4691298B2 (en) * 1999-10-12 2011-06-01 科研製薬株式会社 Powder inhalation preparation and method for producing the same
UA73530C2 (en) 1999-11-10 2005-08-15 Ново Нордіск А/С A compound having properties to release the growth hormone
JP3498041B2 (en) * 2000-05-29 2004-02-16 科研製薬株式会社 Nasal formulation containing pralmorelin
ATE446758T1 (en) 2000-05-31 2009-11-15 Pfizer Prod Inc USE OF GROWTH HORMONE SECRETAGOGENES TO PROMOTE DIGESTIVE MOTILITY
US7622503B2 (en) 2000-08-24 2009-11-24 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US7855229B2 (en) 2000-08-24 2010-12-21 University Of Tennessee Research Foundation Treating wasting disorders with selective androgen receptor modulators
US7645898B2 (en) 2000-08-24 2010-01-12 University Of Tennessee Research Foundation Selective androgen receptor modulators and method of use thereof
US7919647B2 (en) 2000-08-24 2011-04-05 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
EA006484B1 (en) 2001-02-02 2005-12-29 Конджачем, Инк. Long lasting growth hormone releasing factor derivatives
US7125840B2 (en) * 2001-10-09 2006-10-24 Eli Lilly And Company Substituted dipeptides as growth hormone secretagogues
EP1450605B1 (en) * 2001-10-26 2011-12-07 Baylor College Of Medicine Composition to alter bone properties in a subject
US8853266B2 (en) 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
US6831102B2 (en) 2001-12-07 2004-12-14 Bristol-Myers Squibb Company Phenyl naphthol ligands for thyroid hormone receptor
MY142457A (en) * 2001-12-11 2010-11-30 Advisys Inc Plasmid mediated supplementation for treating chronically ill subjects
US7015219B2 (en) 2001-12-19 2006-03-21 Bristol-Myers Squibb Company 3-aryl-hydroxybenzoxazines and 3, 4-dihydro-3-aryl-hydroxybenzoxazines as selective estrogen receptor beta modulators
TW200307749A (en) * 2002-02-07 2003-12-16 Baylor College Medicine Modified pituitary gland development in offspring from expectant mother animals treated with growth hormone releasing hormone therapy
US7772433B2 (en) 2002-02-28 2010-08-10 University Of Tennessee Research Foundation SARMS and method of use thereof
US7381730B2 (en) 2002-03-15 2008-06-03 Bristol-Myers Squibb Company 3-arylquinazoline derivatives as selective estrogen receptor beta modulators
US20060167268A1 (en) * 2002-04-09 2006-07-27 Eli Lilly And Company, Patent Division, Growth hormone secretagogues
ES2271557T3 (en) * 2002-04-09 2007-04-16 Eli Lilly And Company DIPEPTIDIC SECRETAGOGS OF THE HORMONE OF GROWTH.
AU2003225305A1 (en) 2002-05-08 2003-11-11 Bristol-Myers Squibb Company Pyridine-based thyroid receptor ligands
US7405234B2 (en) 2002-05-17 2008-07-29 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
AU2003259340A1 (en) 2002-08-23 2004-03-11 Gestion Univalor Societe En Commandite Growth hormone-releasing peptides in the treatment of prevention of atherosclerosis and hypercholesterolemia
WO2004045518A2 (en) 2002-11-15 2004-06-03 Bristol-Myers Squibb Company Open chain prolyl urea-related modulators of androgen receptor function
US8309603B2 (en) 2004-06-07 2012-11-13 University Of Tennessee Research Foundation SARMs and method of use thereof
TW200504021A (en) 2003-01-24 2005-02-01 Bristol Myers Squibb Co Substituted anilide ligands for the thyroid receptor
US7105537B2 (en) 2003-01-28 2006-09-12 Bristol-Myers Squibb Company 2-substituted cyclic amines as calcium sensing receptor modulators
WO2004067719A2 (en) * 2003-01-28 2004-08-12 Advisys, Inc. Growth hormone releasing hormone (ghrh) for use in reducing culling in herd animals
US7205322B2 (en) 2003-02-12 2007-04-17 Bristol-Myers Squibb Company Thiazolidine compounds as calcium sensing receptor modulators
US7557143B2 (en) 2003-04-18 2009-07-07 Bristol-Myers Squibb Company Thyroid receptor ligands
TW200424214A (en) * 2003-04-21 2004-11-16 Advisys Inc Plasmid mediated GHRH supplementation for renal failures
US7459460B2 (en) 2003-05-28 2008-12-02 Bristol-Myers Squibb Company Trisubstituted heteroaromatic compounds as calcium sensing receptor modulators
US7265145B2 (en) 2003-05-28 2007-09-04 Bristol-Myers Squibb Company Substituted piperidines and pyrrolidines as calcium sensing receptor modulators and method
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
WO2005016964A2 (en) * 2003-08-04 2005-02-24 Advisys, Inc. Canine specific growth hormone releasing hormone
WO2005041998A1 (en) 2003-10-02 2005-05-12 Ali Sadat M Peptide for promoting healing of fractures
ATE467417T1 (en) * 2003-12-31 2010-05-15 VGX Pharmaceuticals LLC REDUCING ARTHRITIS AND LAMENESS IN PERSONS SUPPLEMENTED WITH GROWTH HORMONE RELEASING HORMONE (GHRH)
EP1713828B1 (en) * 2004-01-20 2011-04-27 VGX Pharmaceuticals, LLC Enhanced secretion/retention of growth hormone releasing hormone (ghrh) from muscle cells by species-specific signal peptide
US20050164952A1 (en) * 2004-01-23 2005-07-28 Vital Pharmaceuticals, Inc. Delivery system for growth hormone releasing peptides
US7820702B2 (en) 2004-02-04 2010-10-26 Bristol-Myers Squibb Company Sulfonylpyrrolidine modulators of androgen receptor function and method
US7378426B2 (en) 2004-03-01 2008-05-27 Bristol-Myers Squibb Company Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US7696241B2 (en) 2004-03-04 2010-04-13 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
US7625923B2 (en) 2004-03-04 2009-12-01 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
US9884038B2 (en) 2004-06-07 2018-02-06 University Of Tennessee Research Foundation Selective androgen receptor modulator and methods of use thereof
US9889110B2 (en) 2004-06-07 2018-02-13 University Of Tennessee Research Foundation Selective androgen receptor modulator for treating hormone-related conditions
ATE413890T1 (en) * 2004-07-23 2008-11-15 Advisys Inc GROWTH HORMONE RELEASING HORMONE ENHANCES THE VACCINE-INDUCED IMMUNE RESPONSE
CA2576915A1 (en) 2004-08-18 2006-03-02 Elixir Pharmaceuticals, Inc. Growth-hormone secretagogues
WO2006116401A1 (en) 2005-04-28 2006-11-02 Bristol-Myers Squibb Company C-5 substituted quinazolinone derivatives as selective estrogen receptor beta modulators
KR101388087B1 (en) 2005-08-31 2014-04-25 유니버시티 오브 테네시 리서치 파운데이션 Treating renal disease, burns, wounds and spinal cord injury with selective androgen receptor modulators
CU23558A1 (en) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech COMPOUNDS ANALOG TO THE PEPTIDIC SECRETAGOGS OF THE GROWTH HORMONE
WO2008006019A2 (en) * 2006-07-06 2008-01-10 Advisys Inc. Growth hormone releasing hormone treatment to decrease cholesterol levels
WO2008008433A2 (en) 2006-07-12 2008-01-17 University Of Tennessee Research Foundation Substituted acylanilides and methods of use thereof
KR101410453B1 (en) 2006-08-02 2014-06-27 싸이토키네틱스, 인코포레이티드 Certain chemical entities, compositions and methods
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
US9730908B2 (en) 2006-08-24 2017-08-15 University Of Tennessee Research Foundation SARMs and method of use thereof
US10010521B2 (en) 2006-08-24 2018-07-03 University Of Tennessee Research Foundation SARMs and method of use thereof
US9844528B2 (en) 2006-08-24 2017-12-19 University Of Tennessee Research Foundation SARMs and method of use thereof
CN107007581A (en) 2006-08-24 2017-08-04 田纳西大学研究基金会 Substituted N anilids and its application method
ES2604943T3 (en) 2007-02-09 2017-03-10 Ocera Therapeutics, Inc. Ghrelin receptor macrocyclic modulators and procedures for their use
EP2155769B1 (en) 2007-05-04 2012-06-27 Katholieke Universiteit Leuven KU Leuven Research & Development Tissue degeneration protection
US7968603B2 (en) 2007-09-11 2011-06-28 University Of Tennessee Research Foundation Solid forms of selective androgen receptor modulators
US8003689B2 (en) 2008-06-20 2011-08-23 Gtx, Inc. Metabolites of selective androgen receptor modulators and methods of use thereof
WO2011133920A1 (en) 2010-04-23 2011-10-27 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081626A1 (en) 2010-04-23 2012-10-10 Cytokinetics Inc AMINO-PYRIDAZINIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME TO TREAT CARDIAC AND SKELETIC MUSCULAR DISORDERS
AR081331A1 (en) 2010-04-23 2012-08-08 Cytokinetics Inc AMINO- PYRIMIDINES COMPOSITIONS OF THE SAME AND METHODS FOR THE USE OF THE SAME
WO2013190520A2 (en) 2012-06-22 2013-12-27 The General Hospital Corporation Gh-releasing agents in the treatment of vascular stenosis and associated conditions
US9622992B2 (en) 2012-07-13 2017-04-18 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10314807B2 (en) 2012-07-13 2019-06-11 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9744149B2 (en) 2012-07-13 2017-08-29 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10987334B2 (en) 2012-07-13 2021-04-27 University Of Tennessee Research Foundation Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)
AU2013203600C1 (en) 2012-07-13 2016-11-24 University Of Tennessee Research Foundation A method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMS)
US10258596B2 (en) 2012-07-13 2019-04-16 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9969683B2 (en) 2012-07-13 2018-05-15 Gtx, Inc. Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
CA2889499C (en) 2012-10-24 2019-09-10 Daiichi Sankyo Company, Limited Growth hormone secretagogue receptor agonists for treating amyotrophic lateral sclerosis
WO2014168973A2 (en) 2013-04-08 2014-10-16 President And Fellows Of Harvard College Methods and compositions for rejuvenating skeletal muscle stem cells
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
EP3148587B1 (en) 2014-05-30 2021-02-24 Pfizer Inc Carbonitrile derivatives as selective androgen receptor modulators
US20170121385A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions
EP3990447A1 (en) 2019-06-27 2022-05-04 Cytokinetics, Inc. Polymorphs of 1-(2-((((trans)-3-fluoro-1-(3-fluoropyridin-2-yl)cyclobutyl)methyl)amino)pyrimidin-5-yl)-1h-pyrrole-3-carboxamide
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4223020A (en) * 1979-03-30 1980-09-16 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4228155A (en) * 1979-03-30 1980-10-14 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4228157A (en) * 1979-03-30 1980-10-14 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4228158A (en) * 1979-03-30 1980-10-14 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4226857A (en) * 1979-03-30 1980-10-07 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4228156A (en) * 1979-03-30 1980-10-14 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
CA1175810A (en) * 1979-03-30 1984-10-09 Frank A. Momany Synthetic peptides having pituitary growth hormone releasing activity
US4224316A (en) * 1979-03-30 1980-09-23 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4223021A (en) * 1979-03-30 1980-09-16 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4223019A (en) * 1979-03-30 1980-09-16 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
WO1983002272A1 (en) * 1981-12-28 1983-07-07 Beckman Instruments Inc Synthetic peptides having pituitary growth hormone releasing activity
US4410512A (en) * 1981-12-28 1983-10-18 Beckman Instruments, Inc. Combinations having synergistic pituitary growth hormone releasing activity
US4410513A (en) * 1981-12-28 1983-10-18 Beckman Instruments, Inc. Synthetic peptides having pituitary growth hormone releasing activity
US4880778A (en) * 1986-05-12 1989-11-14 Eastman Kodak Company Combinations having synergistic growth hormone releasing activity and methods for use thereof
US4839344A (en) * 1987-06-12 1989-06-13 Eastman Kodak Company Polypeptide compounds having growth hormone releasing activity
US4880777A (en) * 1987-09-01 1989-11-14 Eastman Kodak Company Synthetic peptides having growth hormone releasing activity
ATE113607T1 (en) * 1988-01-28 1994-11-15 Polygen Holding Corp POLYPEPTIDE COMPOUNDS WITH GROWTH HORMONE RELEASING ACTIVITY.
JPH03502329A (en) * 1988-01-28 1991-05-30 ポリゲン ホールディング コーポレイション Polypeptide compounds with growth hormone-releasing activity
WO1989010933A1 (en) * 1988-05-11 1989-11-16 Eastman Kodak Company Polypeptide compounds having growth hormone releasing activity
IL98910A0 (en) * 1990-07-24 1992-07-15 Polygen Holding Corp Polypeptide compounds having growth hormone releasing activity and pharmaceutical compositions containing them
US5486505A (en) * 1990-07-24 1996-01-23 Polygen Holding Corporation Polypeptide compounds having growth hormone releasing activity
WO1992001709A1 (en) 1990-07-24 1992-02-06 Eastman Kodak Company Process for synthesizing peptides

Also Published As

Publication number Publication date
DK0605484T3 (en) 1999-07-05
FI120691B (en) 2010-01-29
US5776901A (en) 1998-07-07
AU666673B2 (en) 1996-02-22
WO1993004081A1 (en) 1993-03-04
BR9206398A (en) 1994-12-27
AU2541692A (en) 1993-03-16
EP0605484A1 (en) 1994-07-13
DE69227462D1 (en) 1998-12-03
CN1073684A (en) 1993-06-30
CA2116120C (en) 2002-12-03
IL102848A (en) 1998-04-05
NO940592L (en) 1994-04-14
BR1100309A (en) 2000-08-01
CA2116120A1 (en) 1993-02-23
ATE172742T1 (en) 1998-11-15
JPH07507039A (en) 1995-08-03
FI120095B (en) 2009-06-30
NO314695B1 (en) 2003-05-05
NZ244034A (en) 1995-08-28
FI940807A (en) 1994-02-21
BG62655B1 (en) 2000-04-28
CN1035256C (en) 1997-06-25
RO112507B1 (en) 1997-10-30
ES2124263T3 (en) 1999-02-01
HUT69178A (en) 1995-08-28
HU9400495D0 (en) 1994-05-30
DE69227462T2 (en) 1999-04-08
EP0605484B1 (en) 1998-10-28
US5663146A (en) 1997-09-02
BG98489A (en) 1995-02-28
JP3179489B2 (en) 2001-06-25
CZ40094A3 (en) 1994-11-16
IL102848A0 (en) 1993-01-31
ZA926337B (en) 1993-04-22
RU2126014C1 (en) 1999-02-10
KR100247212B1 (en) 2000-03-15
PL169562B1 (en) 1996-08-30
SK20494A3 (en) 1994-10-05
CZ293281B6 (en) 2004-03-17
HU223664B1 (en) 2004-11-29
MX9204861A (en) 1994-06-30
FI940807A0 (en) 1994-02-21
NO940592D0 (en) 1994-02-21
SK282895B6 (en) 2003-01-09

Similar Documents

Publication Publication Date Title
FI20050467A (en) Methods for promoting growth hormone release in an animal
RU94016393A (en) PEPTIDES possessing the ability to stimulate the growth of the growth hormone, method of production, pharmaceutical composition, method of treatment
NZ227788A (en) Peptide having growth hormone regulatory effects, and compositions
DK0732101T3 (en) Use of L-deprenyl to delay age-related impairment of mammalian immune system function
KR890700359A (en) Stable interferon complex
MY113488A (en) Compounds with growth hormone releasing properties
DE68909409D1 (en) MEDICAL DOSAGE FOR ADMINISTRATION TO FISH.
ES8102141A1 (en) 3,7-Disubstituted-3-cephem-4-carboxylic acid compounds
DK0540676T3 (en) Peptide compounds with growth hormone releasing activity
SE8700203D0 (en) PYROGLUTAMIDE DERIVATIVES
JPS5545681A (en) 88chloroo66hydroxyy55methylbenzoic acid derivative
NO934655D0 (en) Drug for gram-positive diseases in aquatic species
SE7704856L (en) MEANS OF ORAL SUPPLY TO PETS WITHOUT CELLULOSE MELTING IN VAM
ATE153859T1 (en) SOMATOTROPINE FOR INCREASING REPRODUCTIVE PERFORMANCE IN CATTLE
ATE59779T1 (en) METHODS OF REGULATION OF ANIMAL REPRODUCTION.
IT8520712A0 (en) PHARMACEUTICAL FORMULATIONS TO STIMULATE THE RELEASE OF SOMATOTROPIC HORMONE.

Legal Events

Date Code Title Description
FG Patent granted

Ref document number: 120691

Country of ref document: FI

MM Patent lapsed