FI20001775A - Imino-substituted cyclopent / b / indole derivatives useful as intermediates - Google Patents
Imino-substituted cyclopent / b / indole derivatives useful as intermediates Download PDFInfo
- Publication number
- FI20001775A FI20001775A FI20001775A FI20001775A FI20001775A FI 20001775 A FI20001775 A FI 20001775A FI 20001775 A FI20001775 A FI 20001775A FI 20001775 A FI20001775 A FI 20001775A FI 20001775 A FI20001775 A FI 20001775A
- Authority
- FI
- Finland
- Prior art keywords
- intermediates
- imino
- indole derivatives
- derivatives useful
- useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
There are disclosed various compounds of the formula below, <CHEM> where n, X and R1 through R4 are as defined in the specification, which are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease. Compounds of this invention also inhibit monoamine oxidase and/or act at central alpha 2-adrenergic receptors, and hence are useful as antidepressants. The invention relates also to intermediates and a process for the preparation of the above compounds.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64295291 | 1991-01-18 | ||
US07/642,952 US5100891A (en) | 1991-01-18 | 1991-01-18 | Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
FI20001775A true FI20001775A (en) | 2000-08-10 |
FI107919B FI107919B (en) | 2001-10-31 |
Family
ID=24578739
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI920192A FI102174B (en) | 1991-01-18 | 1992-01-16 | Process for the preparation of 1,2,3,4-tetrahydro- and 1,2,3,3a, 4,8b-hexahydrocyclopent-b | indole derivatives |
FI20001775A FI107919B (en) | 1991-01-18 | 2000-08-10 | Imino-substituted cyclopent [b] indole derivatives useful as intermediates |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI920192A FI102174B (en) | 1991-01-18 | 1992-01-16 | Process for the preparation of 1,2,3,4-tetrahydro- and 1,2,3,3a, 4,8b-hexahydrocyclopent-b | indole derivatives |
Country Status (26)
Country | Link |
---|---|
US (1) | US5100891A (en) |
EP (1) | EP0496314B1 (en) |
JP (1) | JP2665422B2 (en) |
KR (1) | KR100230881B1 (en) |
AT (1) | ATE158790T1 (en) |
AU (1) | AU650315B2 (en) |
BR (1) | BR9200171A (en) |
CA (1) | CA2059610C (en) |
CZ (1) | CZ282732B6 (en) |
DE (1) | DE69222444T2 (en) |
DK (1) | DK0496314T3 (en) |
ES (1) | ES2109953T3 (en) |
FI (2) | FI102174B (en) |
GR (1) | GR3025318T3 (en) |
HU (1) | HUT67027A (en) |
IE (1) | IE920149A1 (en) |
IL (1) | IL100693A0 (en) |
MX (1) | MX9200206A (en) |
NO (1) | NO178397C (en) |
NZ (1) | NZ241305A (en) |
PH (1) | PH31429A (en) |
PL (2) | PL167465B1 (en) |
RO (1) | RO112505B1 (en) |
RU (1) | RU2077530C1 (en) |
TW (1) | TW198024B (en) |
ZA (1) | ZA92341B (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5298626A (en) * | 1991-01-18 | 1994-03-29 | Hoechst-Roussel Pharmaceuticals Incorporated | Select cyclopent[b]indoles |
US5350762A (en) * | 1993-03-08 | 1994-09-27 | Hoechst-Roussel Pharmaceuticals Incorporated | Tetrahydrocyclopent[B]indole methanamines and related compounds |
ES2149742T1 (en) * | 1997-07-03 | 2000-11-16 | Asahi Chemical Ind | NEW TRICYCLIC COMPOUNDS THAT HAVE SATURATED RINGS AND MEDICINAL COMPOSITIONS THAT CONTAIN THEM. |
UA70334C2 (en) * | 1998-10-06 | 2004-10-15 | Janssen Pharmaceutica N V Jans | BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS |
UA69420C2 (en) * | 1998-10-06 | 2004-09-15 | Янссен Фармацевтика Н.В. | TRICYCLIC D3-PIPERIDINES AS a<sub>2-ANTAGONISTS |
KR20010071844A (en) * | 1998-10-06 | 2001-07-31 | 디르크 반테 | Tricyclic Δ3-piperidines as pharmaceuticals |
IT1317926B1 (en) | 2000-11-03 | 2003-07-15 | Sigma Tau Ind Farmaceuti | TRICYCLIC DERIVATIVES OF INDOLE FOR ANTIANGIOGENIC ACTIVITY. |
ES2314446T3 (en) | 2003-06-10 | 2009-03-16 | Smithkline Beecham Corporation | DERIVATIVES OF TETRAHYDROCARBAZOL AND ITS PHARMACEUTICAL USE. |
EP1646610B1 (en) * | 2003-06-12 | 2009-07-22 | SmithKline Beecham Corporation | Tetrahydrocarbazole derivatives and their pharmaceutical use |
US8946444B2 (en) * | 2004-11-23 | 2015-02-03 | Ptc Therapeutics, Inc. | Tetrahydrocarbazoles as active agents for inhibiting VEGF production by translational control |
GB2422828A (en) * | 2005-02-03 | 2006-08-09 | Hunter Fleming Ltd | Tricyclic cytoprotective compounds comprising an indole residue |
WO2013139929A1 (en) * | 2012-03-22 | 2013-09-26 | Ludwig-Maximilians-Universität München | Novel means and methods for treating diseases of the central nervous system, metabolic and cardiac diseases and aging |
KR20140013471A (en) | 2012-07-24 | 2014-02-05 | 주식회사 쎄코 | Heating assembly for vacuum deposition and vacuum deposition apparatus having the same |
US10882821B1 (en) | 2017-09-26 | 2021-01-05 | The Board Of Trustees Of The Leland Stanford Junior University | Enantiomeric compound for the reduction of the deleterious activity of extended nucleotide repeat containing genes |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3514462A (en) * | 1966-10-21 | 1970-05-26 | Upjohn Co | 1 and 2 ethoxy 3,4,5,10 - tetrahydroazepino(3,4-b) and (2,3-b)indoles and corresponding amino derivatives thereof |
US3595874A (en) * | 1969-02-28 | 1971-07-27 | Upjohn Co | 3,4,5,10-tetrahydroazepino(2,3-b)indol-5a (2h)-ols |
BE787537A (en) * | 1971-08-16 | 1973-02-14 | Sterling Drug Inc | TETRAHYDROCARBAZOLES |
SU482086A1 (en) * | 1973-11-30 | 1976-03-15 | Всесоюзный Научно-Исследовательски% Химико-Фармацевтический Институт Им.С.Орджоникидзе | The method of obtaining derivatives of 1-α-amino 1,2,3,4-tetrahydrocarbazole |
FR2275202A1 (en) * | 1974-06-18 | 1976-01-16 | Ayerst Mckenna & Harrison | ALCOYLAMINE TRICYCLIC DERIVATIVES AND PREPARATION OF THEM |
US4254134A (en) * | 1978-03-17 | 1981-03-03 | Endo Laboratories, Inc. | Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles |
-
1991
- 1991-01-18 US US07/642,952 patent/US5100891A/en not_active Expired - Lifetime
-
1992
- 1992-01-15 RO RO149168A patent/RO112505B1/en unknown
- 1992-01-15 NZ NZ241305A patent/NZ241305A/en unknown
- 1992-01-16 CZ CS92129A patent/CZ282732B6/en not_active IP Right Cessation
- 1992-01-16 KR KR1019920000543A patent/KR100230881B1/en not_active IP Right Cessation
- 1992-01-16 PL PL92296651A patent/PL167465B1/en unknown
- 1992-01-16 FI FI920192A patent/FI102174B/en active
- 1992-01-16 PL PL92293209A patent/PL169417B1/en unknown
- 1992-01-17 CA CA002059610A patent/CA2059610C/en not_active Expired - Lifetime
- 1992-01-17 AU AU10279/92A patent/AU650315B2/en not_active Ceased
- 1992-01-17 IL IL100693A patent/IL100693A0/en unknown
- 1992-01-17 IE IE014992A patent/IE920149A1/en not_active IP Right Cessation
- 1992-01-17 HU HU9200172A patent/HUT67027A/en unknown
- 1992-01-17 ZA ZA92341A patent/ZA92341B/en unknown
- 1992-01-17 MX MX9200206A patent/MX9200206A/en unknown
- 1992-01-17 JP JP4006681A patent/JP2665422B2/en not_active Expired - Lifetime
- 1992-01-17 NO NO920235A patent/NO178397C/en unknown
- 1992-01-17 RU SU925010763A patent/RU2077530C1/en active
- 1992-01-18 ES ES92100816T patent/ES2109953T3/en not_active Expired - Lifetime
- 1992-01-18 DE DE69222444T patent/DE69222444T2/en not_active Expired - Lifetime
- 1992-01-18 EP EP92100816A patent/EP0496314B1/en not_active Expired - Lifetime
- 1992-01-18 AT AT92100816T patent/ATE158790T1/en not_active IP Right Cessation
- 1992-01-18 DK DK92100816.5T patent/DK0496314T3/en active
- 1992-01-21 BR BR929200171A patent/BR9200171A/en not_active Application Discontinuation
- 1992-02-20 TW TW081101228A patent/TW198024B/zh active
- 1992-11-20 PH PH43793A patent/PH31429A/en unknown
-
1997
- 1997-11-07 GR GR970402960T patent/GR3025318T3/en unknown
-
2000
- 2000-08-10 FI FI20001775A patent/FI107919B/en active
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