FI20000085A - Process for the preparation of therapeutically active 4-amino-substituted 2-azabicyclo / 3.3.1 / nonane derivatives - Google Patents

Process for the preparation of therapeutically active 4-amino-substituted 2-azabicyclo / 3.3.1 / nonane derivatives Download PDF

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Publication number
FI20000085A
FI20000085A FI20000085A FI20000085A FI20000085A FI 20000085 A FI20000085 A FI 20000085A FI 20000085 A FI20000085 A FI 20000085A FI 20000085 A FI20000085 A FI 20000085A FI 20000085 A FI20000085 A FI 20000085A
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FI
Finland
Prior art keywords
pct
azabicyclo
amino
substituted
preparation
Prior art date
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FI20000085A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI106457B (en
Inventor
Manoj C Desai
Original Assignee
Pfizer
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Publication date
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Publication of FI20000085A publication Critical patent/FI20000085A/en
Application granted granted Critical
Publication of FI106457B publication Critical patent/FI106457B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

PCT No. PCT/US93/01429 Sec. 371 Date Nov. 7, 1994 Sec. 102(e) Date Nov. 7, 1994 PCT Filed Feb. 23, 1993 PCT Pub. No. WO93/23380 PCT Pub. Date Nov. 25, 1993.The invention relates to bridged aza-bicyclic derivatives of formula (I). These compounds are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders. Also disclosed are intermediates used in the synthesis of compound of formula (I). <IMAGE> (I)
FI20000085A 1992-05-18 2000-01-17 Process for the preparation of therapeutically active 4-amino-substituted 2-azabicyclo [3.3.1] nonane derivatives FI106457B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88511092A 1992-05-18 1992-05-18
US88511092 1992-05-18

Publications (2)

Publication Number Publication Date
FI20000085A true FI20000085A (en) 2000-01-17
FI106457B FI106457B (en) 2001-02-15

Family

ID=25386157

Family Applications (2)

Application Number Title Priority Date Filing Date
FI932229A FI932229A (en) 1992-05-18 1993-05-17 AZABICYCLISKA BRYGGDERIVAT
FI20000085A FI106457B (en) 1992-05-18 2000-01-17 Process for the preparation of therapeutically active 4-amino-substituted 2-azabicyclo [3.3.1] nonane derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI932229A FI932229A (en) 1992-05-18 1993-05-17 AZABICYCLISKA BRYGGDERIVAT

Country Status (11)

Country Link
US (1) US5498614A (en)
EP (1) EP0641328B1 (en)
JP (1) JP2757234B2 (en)
AT (1) ATE209186T1 (en)
CA (1) CA2134964C (en)
DE (1) DE69331190T2 (en)
DK (1) DK0641328T3 (en)
ES (1) ES2164657T3 (en)
FI (2) FI932229A (en)
PT (1) PT641328E (en)
WO (1) WO1993023380A1 (en)

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Also Published As

Publication number Publication date
ATE209186T1 (en) 2001-12-15
EP0641328A1 (en) 1995-03-08
FI106457B (en) 2001-02-15
WO1993023380A1 (en) 1993-11-25
DE69331190T2 (en) 2002-04-18
ES2164657T3 (en) 2002-03-01
DE69331190D1 (en) 2002-01-03
JPH07503483A (en) 1995-04-13
PT641328E (en) 2002-04-29
FI932229A0 (en) 1993-05-17
DK0641328T3 (en) 2002-05-21
CA2134964A1 (en) 1993-11-25
EP0641328B1 (en) 2001-11-21
CA2134964C (en) 1997-12-30
JP2757234B2 (en) 1998-05-25
FI932229A (en) 1993-11-19
US5498614A (en) 1996-03-12

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