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Viratek Inc
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Viratek Inc
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Publication date
Application filed by Viratek IncfiledCriticalViratek Inc
Priority to ES557159ApriorityCriticalpatent/ES557159A0/en
Publication of ES8802057A3publicationCriticalpatent/ES8802057A3/en
Publication of ES557159A0publicationCriticalpatent/ES557159A0/en
1-(beta-D-Ribofuranosyl) 1,2,4-triazole 3-carboxamide, for use as an antitumour agent, is made by (a) recting suitable molar amounts of the methyl ester of 1-(2,3,5-tri-O-R -D-ribofuranosyl) 1,2,4-triazole 3-carboxylic acid, in which R is benzoyl or acetyl, with anhydrous ammonia in methanol at 0 deg.C; (b) maintaining in a closed vessel for 72 hours at 25 deg.C; (c) evaporating in a rotary evaporator under reduced pressure at 35 deg.C; and (d) crystallising from ethanol.
ES557159A1986-10-311986-10-31
A PROCEDURE FOR PREPARING 1- (B-D-RIVOFURANOSIL) -1,2,4-TRIAZOL-3-CARBOXAMIDE
GrantedES557159A0
(en)
Stereoselective process for preparing .beta.-anomer enriched 2-deoxy-2,2-difluoro-d-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonate intermediates
Procedure for the preparation of 1-(3-mercaptan-(2s)-methylpropionyl)-pyrolidine-(2s)-carb<543>oxylic acid or its pharmaceutically acceptable salts.