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F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
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Application filed by F Hoffmann La Roche AGfiledCriticalF Hoffmann La Roche AG
Publication of ES8708219A1publicationCriticalpatent/ES8708219A1/es
Publication of ES550204A0publicationCriticalpatent/ES550204A0/es
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions
(AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR OXETANONAS. COMPRENDE: A) ESTERIFICAR UN ACIDO DE FORMULA (II) CON UN ALCOHOL DE FORMULA (III), EN TETRAHIDROFURANO Y EN PRESENCIA DE TRIFENILFOSFINA Y AZODICARBOXILATO DIETILICO, PARA OBTENER UN COMPUESTO DE FORMULA (IV); Y B) HIDROGENAR A (IV), EN THF Y EN PRESENCIA DE PD/C PARA DISOCIAR EL GRUPO W DE (IV) Y OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES DEBILES. SIENDO. R ELEVADO A 1 Y R CUADRADO, ALQUILO DE C 1 A 17 CON 8 DOBLES O TRIPLES ENLACES, FENILO Y OTROS; R CUBO Y R ELEVADO A 4, H, ALQUILO DE C 1 A 3 Y OTROS; R ELEVADO A 5, H AR Y OTROS; X, O, S Y OTROS; Y W, BENCILOXICARBONILO Y OTROS. SE UTILIZAN PARA CONTROLAR LA OBESIDAD Y LA HIPERLIPEMIA. *FORMULA* L
ES550204A1984-12-211985-12-20Un procedimiento para la preparacion de oxetanonas
ExpiredES8708219A1
(es)