ES8708141A1 - Anti-cancer compsn. contg. 5-fluoro-uracil or cpd. forming it in vivo - Google Patents

Anti-cancer compsn. contg. 5-fluoro-uracil or cpd. forming it in vivo

Info

Publication number
ES8708141A1
ES8708141A1 ES549011A ES549011A ES8708141A1 ES 8708141 A1 ES8708141 A1 ES 8708141A1 ES 549011 A ES549011 A ES 549011A ES 549011 A ES549011 A ES 549011A ES 8708141 A1 ES8708141 A1 ES 8708141A1
Authority
ES
Spain
Prior art keywords
alkyl
cpd
alkylcarbamoyl
iii
vivo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES549011A
Other languages
Spanish (es)
Other versions
ES549011A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP59229938A external-priority patent/JPS61106593A/en
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of ES8708141A1 publication Critical patent/ES8708141A1/en
Publication of ES549011A0 publication Critical patent/ES549011A0/en
Expired legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Anticancer compsn. comprises 5-fluorouracil (I) or a cpd. (II) capable of producing (I) in vivo together with a pyridine deriv. of formula (III). In (III) R1 = OH or acyloxy R2, R4 = H, halogen, NH2, COOH, CONH2, CN, NO2, 1-6C alkyl, 2-6C alkenyl or (1-6C)alkoxycarbonyl R3, R5 = H, OH or acyloxy. When at least one of R1, R3 and R5 = OH, then the 1-posn. of the (III) ring may have the -NH- structure by keto-enol tautomerism, and this H atom may be replaced by 1-6C alkyl, tetrahydrofuranyl, tetrahydropyranyl, (1-6C) alkoxy-(1-6C)alkyl, phthalidyl, CONH2, (1-6C)alkoxycarbonyl-(1-6C)alkylcarbamoyl, Ph-(1-6C)alkoxy-(1-6C)alkyl, phenylcarbamoyl (itself opt. ring substd.), (1-6C)alkylcarbamoyl, COOH-(1-6C)alkylcarbamoyl, (1-6C)alkylthio-(1-6C)alkyl or 2-6C alkenyl. Provided that (III) is not a cpd. of formula (IV), where R = H, 1-6C alkyl, tetrahydrofuranyl, tetrahydropyranyl, (1-6C)alkoxy-(1-6C)alkyl, (1-6C)alkylcarbamoyl, (1-6C)alkylthio-(1-6C)alkyl or 2-6C alkenyl.
ES549011A 1984-10-30 1985-10-30 Anti-cancer compsn. contg. 5-fluoro-uracil or cpd. forming it in vivo Expired ES8708141A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP59229938A JPS61106593A (en) 1984-10-30 1984-10-30 2'-deoxy-5-fluorouridine derivative
JP25458784 1984-11-30
JP719085 1985-01-17

Publications (2)

Publication Number Publication Date
ES8708141A1 true ES8708141A1 (en) 1987-10-01
ES549011A0 ES549011A0 (en) 1987-10-01

Family

ID=27277502

Family Applications (1)

Application Number Title Priority Date Filing Date
ES549011A Expired ES8708141A1 (en) 1984-10-30 1985-10-30 Anti-cancer compsn. contg. 5-fluoro-uracil or cpd. forming it in vivo

Country Status (1)

Country Link
ES (1) ES8708141A1 (en)

Also Published As

Publication number Publication date
ES549011A0 (en) 1987-10-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20060623