ES8707524A1 - Di:phenyl-methyl -piperazinyl di:hydrazolylone propane mfr. - Google Patents

Di:phenyl-methyl -piperazinyl di:hydrazolylone propane mfr.

Info

Publication number
ES8707524A1
ES8707524A1 ES541562A ES541562A ES8707524A1 ES 8707524 A1 ES8707524 A1 ES 8707524A1 ES 541562 A ES541562 A ES 541562A ES 541562 A ES541562 A ES 541562A ES 8707524 A1 ES8707524 A1 ES 8707524A1
Authority
ES
Spain
Prior art keywords
propane
piperazinyl
hydrazolylone
mfr
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES541562A
Other languages
Spanish (es)
Other versions
ES541562A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcaloides Abello S A
Original Assignee
Alcaloides Abello S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcaloides Abello S A filed Critical Alcaloides Abello S A
Priority to ES541562A priority Critical patent/ES8707524A1/en
Publication of ES541562A0 publication Critical patent/ES541562A0/en
Publication of ES8707524A1 publication Critical patent/ES8707524A1/en
Expired legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1-(1-(4-diphenylmethyl piperazinyl) 3-(1-(1,3-dihydrazolyl-2 -one)) propane, for use as an anti-histamine agent, is made by (a) reacting 4-diphenylmethyl piperazine (I) with an alkyl acrylate CH2 =CHCOOR, (V) opt in presence of solvent, at low temp to obtain a cpd of formula (II); (b) reducing with an alkali or alkaline earth borohydride or aluminium hydride in ethyl ether, THF or similar at 20-80 deg C for 1-480 hours to give (III); (c) treating this with methane sulphonic, benzene sulphonic or other sulphonic acid chloride in benzene, toluene or other solvent to obtain the ester (IV); and (d) reacting this with 1,3-dihydrobenzo 1,3-diazolone.
ES541562A 1985-03-26 1985-03-26 Di:phenyl-methyl -piperazinyl di:hydrazolylone propane mfr. Expired ES8707524A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES541562A ES8707524A1 (en) 1985-03-26 1985-03-26 Di:phenyl-methyl -piperazinyl di:hydrazolylone propane mfr.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES541562A ES8707524A1 (en) 1985-03-26 1985-03-26 Di:phenyl-methyl -piperazinyl di:hydrazolylone propane mfr.

Publications (2)

Publication Number Publication Date
ES541562A0 ES541562A0 (en) 1986-04-01
ES8707524A1 true ES8707524A1 (en) 1986-04-01

Family

ID=8488886

Family Applications (1)

Application Number Title Priority Date Filing Date
ES541562A Expired ES8707524A1 (en) 1985-03-26 1985-03-26 Di:phenyl-methyl -piperazinyl di:hydrazolylone propane mfr.

Country Status (1)

Country Link
ES (1) ES8707524A1 (en)

Also Published As

Publication number Publication date
ES541562A0 (en) 1986-04-01

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