ES8707524A1 - Di:phenyl-methyl -piperazinyl di:hydrazolylone propane mfr. - Google Patents
Di:phenyl-methyl -piperazinyl di:hydrazolylone propane mfr.Info
- Publication number
- ES8707524A1 ES8707524A1 ES541562A ES541562A ES8707524A1 ES 8707524 A1 ES8707524 A1 ES 8707524A1 ES 541562 A ES541562 A ES 541562A ES 541562 A ES541562 A ES 541562A ES 8707524 A1 ES8707524 A1 ES 8707524A1
- Authority
- ES
- Spain
- Prior art keywords
- propane
- piperazinyl
- hydrazolylone
- mfr
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1-(1-(4-diphenylmethyl piperazinyl) 3-(1-(1,3-dihydrazolyl-2 -one)) propane, for use as an anti-histamine agent, is made by (a) reacting 4-diphenylmethyl piperazine (I) with an alkyl acrylate CH2 =CHCOOR, (V) opt in presence of solvent, at low temp to obtain a cpd of formula (II); (b) reducing with an alkali or alkaline earth borohydride or aluminium hydride in ethyl ether, THF or similar at 20-80 deg C for 1-480 hours to give (III); (c) treating this with methane sulphonic, benzene sulphonic or other sulphonic acid chloride in benzene, toluene or other solvent to obtain the ester (IV); and (d) reacting this with 1,3-dihydrobenzo 1,3-diazolone.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES541562A ES8707524A1 (en) | 1985-03-26 | 1985-03-26 | Di:phenyl-methyl -piperazinyl di:hydrazolylone propane mfr. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES541562A ES8707524A1 (en) | 1985-03-26 | 1985-03-26 | Di:phenyl-methyl -piperazinyl di:hydrazolylone propane mfr. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES541562A0 ES541562A0 (en) | 1986-04-01 |
ES8707524A1 true ES8707524A1 (en) | 1986-04-01 |
Family
ID=8488886
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES541562A Expired ES8707524A1 (en) | 1985-03-26 | 1985-03-26 | Di:phenyl-methyl -piperazinyl di:hydrazolylone propane mfr. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES8707524A1 (en) |
-
1985
- 1985-03-26 ES ES541562A patent/ES8707524A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES541562A0 (en) | 1986-04-01 |
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