ES8707175A1 - N-Methyl tri:fluoro:methyl-phenoxy phenyl-propylamine prepn. - Google Patents

N-Methyl tri:fluoro:methyl-phenoxy phenyl-propylamine prepn.

Info

Publication number
ES8707175A1
ES8707175A1 ES556009A ES556009A ES8707175A1 ES 8707175 A1 ES8707175 A1 ES 8707175A1 ES 556009 A ES556009 A ES 556009A ES 556009 A ES556009 A ES 556009A ES 8707175 A1 ES8707175 A1 ES 8707175A1
Authority
ES
Spain
Prior art keywords
methyl
propylamine
prepn
fluoro
phenoxy phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES556009A
Other languages
Spanish (es)
Other versions
ES556009A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inke SA
Original Assignee
Inke SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inke SA filed Critical Inke SA
Priority to ES556009A priority Critical patent/ES8707175A1/en
Publication of ES8707175A1 publication Critical patent/ES8707175A1/en
Publication of ES556009A0 publication Critical patent/ES556009A0/en
Expired legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

N-Methyl 3-(p-trifluoromethyl phenoxy) 3-phenyl propylamine is made by (a) reaction of p-trifluoromethyl phenol with a molar equiv. of a cpd. of formula (I), in which P is a protective gp., in alcoholic medium in presence of NaOH or KOH at 60-100 deg.C and (b) removal of P in an inert solvent in acid medium at from 20 deg.C to reflux temp..
ES556009A 1986-06-13 1986-06-13 N-Methyl tri:fluoro:methyl-phenoxy phenyl-propylamine prepn. Expired ES8707175A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES556009A ES8707175A1 (en) 1986-06-13 1986-06-13 N-Methyl tri:fluoro:methyl-phenoxy phenyl-propylamine prepn.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES556009A ES8707175A1 (en) 1986-06-13 1986-06-13 N-Methyl tri:fluoro:methyl-phenoxy phenyl-propylamine prepn.

Publications (2)

Publication Number Publication Date
ES8707175A1 true ES8707175A1 (en) 1987-07-16
ES556009A0 ES556009A0 (en) 1987-07-16

Family

ID=8491471

Family Applications (1)

Application Number Title Priority Date Filing Date
ES556009A Expired ES8707175A1 (en) 1986-06-13 1986-06-13 N-Methyl tri:fluoro:methyl-phenoxy phenyl-propylamine prepn.

Country Status (1)

Country Link
ES (1) ES8707175A1 (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2101650A1 (en) * 1995-06-29 1997-07-01 Lilly Sa Process for the preparation of N-methyl-3-phenyl-3-(P- trifluoromethylphenoxy) propylamine
ES2101655A1 (en) * 1995-07-28 1997-07-01 Lilly Sa Process for the preparation of N-methyl-3-phenyl-3-(p- trifluoromethylphenoxy)propylamine
ES2101654A1 (en) * 1995-07-24 1997-07-01 Lilly Sa Process for the preparation of N-methyl-3-phenyl-3-(p- trifluoromethyl-phenoxy) propylamine
ES2103681A1 (en) * 1995-09-19 1997-09-16 Lilly Sa Process for the preparation of N-methyl-3-phenyl-3-(p- trifluoromethylphenoxy)propylamine
ES2103680A1 (en) * 1995-08-03 1997-09-16 Lilly Sa Process for the preparation of N-methyl-3-phenyl-3-(p- trifluoromethylphenoxy) propylamine
US7619006B2 (en) * 2001-09-27 2009-11-17 Ramot At Tel Aviv University Ltd. Conjugated psychotropic drugs and uses thereof
AU2008243147B2 (en) * 2001-09-27 2011-04-07 Bar Ilan University Conjugated Psychotropic Drugs and Uses Thereof
US8207369B2 (en) 2008-02-11 2012-06-26 Ramot At Tel-Aviv University Ltd. Conjugates for treating neurodegenerative diseases and disorders
US8222296B2 (en) 2006-07-17 2012-07-17 Ramot At Tel-Aviv University Ltd. Conjugates comprising a GABA- or glycine compound, pharmaceutical compositions and combinations thereof and their use in treating CNS disorders
US8916610B2 (en) 2010-09-22 2014-12-23 Ramot At Tel-Aviv University Ltd. Acid addition salt of a nortriptyline-GABA conjugate and a process of preparing same
US8975251B2 (en) 2009-12-09 2015-03-10 Bar-Ilan University Methods of improving cognitive functions

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2101650A1 (en) * 1995-06-29 1997-07-01 Lilly Sa Process for the preparation of N-methyl-3-phenyl-3-(P- trifluoromethylphenoxy) propylamine
ES2101654A1 (en) * 1995-07-24 1997-07-01 Lilly Sa Process for the preparation of N-methyl-3-phenyl-3-(p- trifluoromethyl-phenoxy) propylamine
ES2101655A1 (en) * 1995-07-28 1997-07-01 Lilly Sa Process for the preparation of N-methyl-3-phenyl-3-(p- trifluoromethylphenoxy)propylamine
ES2103680A1 (en) * 1995-08-03 1997-09-16 Lilly Sa Process for the preparation of N-methyl-3-phenyl-3-(p- trifluoromethylphenoxy) propylamine
ES2103681A1 (en) * 1995-09-19 1997-09-16 Lilly Sa Process for the preparation of N-methyl-3-phenyl-3-(p- trifluoromethylphenoxy)propylamine
US8168628B2 (en) 2001-09-27 2012-05-01 Ramot At Tel-Aviv University Ltd. Conjugated psychotropic drugs and uses thereof
AU2008243147B2 (en) * 2001-09-27 2011-04-07 Bar Ilan University Conjugated Psychotropic Drugs and Uses Thereof
US7939525B2 (en) 2001-09-27 2011-05-10 Bar-Ilan University Conjugated psychotropic drugs and uses thereof
US7619006B2 (en) * 2001-09-27 2009-11-17 Ramot At Tel Aviv University Ltd. Conjugated psychotropic drugs and uses thereof
US8283381B2 (en) 2001-09-27 2012-10-09 Ramot At Tel-Aviv University Ltd. Conjugated psychotropic drugs and uses thereof
US8222296B2 (en) 2006-07-17 2012-07-17 Ramot At Tel-Aviv University Ltd. Conjugates comprising a GABA- or glycine compound, pharmaceutical compositions and combinations thereof and their use in treating CNS disorders
US8377990B2 (en) 2006-07-17 2013-02-19 Ramot At Tel-Aviv University Ltd. Conjugates comprising a psychotropic drug or a GABA agonist and an organic acid and their use in treating pain and other CNS disorders
US8207369B2 (en) 2008-02-11 2012-06-26 Ramot At Tel-Aviv University Ltd. Conjugates for treating neurodegenerative diseases and disorders
US8722923B2 (en) 2008-02-11 2014-05-13 Ramot At Tel-Aviv University Ltd. Conjugates for treating neurodegenerative diseases and disorders
US8975251B2 (en) 2009-12-09 2015-03-10 Bar-Ilan University Methods of improving cognitive functions
US8916610B2 (en) 2010-09-22 2014-12-23 Ramot At Tel-Aviv University Ltd. Acid addition salt of a nortriptyline-GABA conjugate and a process of preparing same

Also Published As

Publication number Publication date
ES556009A0 (en) 1987-07-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20070526